LRP6 (AK094666) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ADCAD2; STHAG7
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK094666, the custom clone sequence may differ by one or more nucleotides TTTAATGAGAGAATTGTCAAATTTGGAAAGATTTATTGAGCCTTAGGTTACATGGACAGTTAAGCTTAAG TAAACTGTATATTGATTATCAAACACAAGCTGTAATTGGAAAAGTTGAGAGGAAAAGCATGAGATCACAA ATTAGGGGGAAAAAAGAAAAGGGATTTTTAAATTTGGTGTATTAAATTCATTGTCCAAGGGGGAAAATGA ATAATGTTTCATTAGATTCCTTATATGCAAAAGTATTTATTTTGAACATGTGTCCTAAAATATATGCACT AACTGATGTGATTAAAATTGTCCAAGAAATAAACTTGAGCATAACATACTTTGTGTGCACCACAGTAAGC TATTCTGCATTGAAGTGGTCTTTTATAACTAAGGCCTGGACTTTGCTCCAACAGAGTCGTGGTCTTCTGA ATAGTGACTTAAGGAGTTTTGTTTGCTTAAGTCAGATAATAGCACATTCACAGGGAAACAAAGAGAGTTG GTGGATAGAATTTTCTGACTATTAATTTTTCTTCCATGAAATTTTATTATGCCTTTGGCACTTTCTGCCA CTCTTACAGCATATCACAAGATATCTGTTTAGCAGAAGATTATGTAGTTACTTTAATTTTAATATAAAAG TAGCTTGTGATACATTACCAAGAGATCTCTGATTCTTTAGTAAGTTTGAGAACACCTATTCTACAGAGAT GATAGGTACTTAGAAATGAAGACTTTAAAGTACATTTTAATCTAATATAGGCCAGTAATTGGGGGAAGGG GCTTTGAGCAGTACAATTTTAAGATGATTTTGAGGGTTGTATTTCTTTATCATTTAAAAATATCCTAAAG TCAGTAATTTATATGAAGGAAACTCATTCATTATTGAAGGTATTAAAAATAGCCATCATCTGTATTAGGT AGCAGTTTTGGAGGATCATCTTTTTCTTTTGCTATAAAGCCCTATTAATGAAGAATACTTCCAGTAGAGT TAATAGCTGTAGCTTACCTAGTGTGTTAATGAAGTGTGTTTATTTATGTGACTTGATACCAGTAGTCATA ATAGAGACTGAAGAGGTATGCGTTAAGCACGCCTACTTCTATGCAGTAAACAGGCTGCAGCTGCCTAGAT TAGATTCTTAGAAATGTCATATTTTGAATTGTTTTATTTCTTGTAGGGGAAGCTTTGTCCCACTTCATTC ATTTGCATGCCATAGGAATTACATATTGGTTATCATTACGTATCTAACAAGATTCAGAAACAAAAATCTT GGACTTTTCACATCCGAAATATGTCAGCTCTTAATAAATGTGTGGTGCTTAAGTCTACATATGGCATCCA TAGTTGATCTAGAGTATGGATATGAGTGTGTTGACCAGTTATCAGTAGGTGGACAAATATTTGGGCATCT ACAGATGAGACTATGCACTAAGTGTGGACTGAGTCCTAAAGAAGCTTATAGTCAGGTGTTGTTTAAAACA TTATCAGAATTCTTAAACCCAAGGAATTTAATTTTATTTGGTATTTCTTAAGCCTAAAATGAACCAAGAG AAAGATGATTTTAGAAAGTACTTGTAGTGAAAGATGATTTTAGAAAGTACTTGTAGTGCATGTGTGGCTT CTGACTTTTGGGATGGCACCATTTTATAATAGTTTCAAAATTTAGCTTTTGAAATTCTCAACATTTTATG GTAGAAGACTTTGGACCTCAAGTATAAAATTATACGTTTATAATTTTTTTAAAATTTAAATTATAAGTAT TGTGAATTCACACTCTCAGGCTATTGTCTGACTTGATCTACGTCTCATAAAGCCTGTACCTGAGTGGAGT GGAAGGTGGAGTCTTAGGTTAATCAGTTACTGACTCTACCCTCACCCTCTTTCAATTGAGGTAAACTTTG CTGTTTTTCTTTTTCATAAAGCATTCTCAAATTGTTGAGTTTATTGCTGAAAAAAATCTCCATGACTTTA CAGATAGAATTACAAACTAAATGATGTCTTGTATTTAGAAGCAGAGTACAGACCTAACGAACTGTTAGAT TCTCCACCATCACTTAGGGTTTGCCCAGAAGCAACACCAGAGAATTACAGACAACGCGCTTTTGCTGAAC TGTCCATTTTGGTGGTTGTGTTTTTCAGTCAAATATAAGCAGGATGGGCGATAGAGATATATTTATATAT AGATACATATTCTATATATCTAATGCCTAAATATGGGTATTAAAGGGAAAATTTTTAAAGTCTGATTAAA TCCAATATGACATGAAATTAAATATATGGATTAGTAAGGAAAAATGTTAAAAAGTAGAGAGGATACCAAG AAGATTAAACTGGACTAGCCTTATTTGCAAGTGAAGGATCTGGTGCTGCTTTCAGATGTTTATCTTTTAT TTTTTTCCCTTAAGCTTTAATCTTCGTCATTGTCTTAAAGTCAACTGGTGTTTCTTGTTCATTGACTTTG GTACGATGGTGCTTTGCAAGGATGTATTTATGTTATAATGGCCAACATTTGGTCAGCCCTTGTCCACTTA TTCACTTCCCTCCTTTTGTAAAATAAGTGCTTTAATTATAAACTGTATAAAAATACCTTGTATAAACCCC TTTTTTGATTATTACAATAAATAAGCTGAATTGTAACAAATGAAATTTGATTTTTGTAATAAAACAGTGG AAAAGT 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK094666 unedited TCACCAATATGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGCTCTTCT TCAAAATACTAATTTGTGTGCCAATTTGTTTAAAATTATTTGAAGGCAGTTCAGCCTAAT CTCAGTGTTCTCTTTCTGGGGTAGATGAGATGGATTCTTAATATTTCTGGGAGTACTTTT TAATGAGAGAATTGTCAAATTTGGAAAGATTTATTGAGCCTTAGGTTACATGGACAGTTA AGCTTAAGTAAACTGTATATTGATTATCAAACACAAGCTGTAATTGGAAAAGTTGAGAGG AAAAGCATGAGATCACAAATTAGGGGGAAAAAAGAAAAGGGATTTTTAAATTTGGTGTAT TAAATTCATTGTCCAAGGGGGAAAATGAATAATGTTTCATTAGATTCCTTATATGCAAAA GTATTTATTTTGAACATGTGTCCTAAAATATATGCACTAACTGATGTGATTAAAATTGTC CAAGAAATAAACTTGAGCATAACATACTTTGTGTGCACCACAGTAAGCTATTCTGCATTG AAGTGGTCTTTTATAACTAAGGCCTGTACTTTGCTCCAACAGAGTCGTGGTCTTCTGAAT AGTGACTTAAAGAGTTTTGTTTGCTTTAGTCAGCATATAGCACATTCACAGGGAAACAAA GAGAGTTGTTGGATAGAATTTTCTGACTATTTATTTTTCTTCCATGAAATTTTATTATGC CTTTTGGCACTTTCTGCCACTCTTACAGCATATCACAAGATATCTGTTTACCACAGATTA TGTAGGTACTTTAATTTTATTCTAAAGTAGCTTGGATTCATTACCCAGAGGACTCTGATT TTTTAGTACGTTGGAAACCCCTATTCTACAAAAAGATTGGTCCTAAAACTGGAGACTTTA AAGTCACTTTATTTATTTAGCCCCTATTTGGGGAAGGGGCTTTGCCCCCACATTTAAAAA ATTTGAGGTTGTT 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for AK094666 unedited ACTATGNAACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTT TTACTTTTCCACTGTTTTATTACAAAAATCAAATTTCATTTGTTACAATTCAGCTTATTT ATTGTAATAATCAAAAAAGGGGTTTATACAAGGTATTTTTATACAGTTTATAATTAAAGC ACTTATTTTACAAAAGGAGGGAAGTGAATAAGTGGACAAGGGCTGACCAAATGTTGGCCA TTATAACATAAATACATCCTTGCAAAGCACCATCGTACCAAAGTCAATGAACAAGAAACA CCAGTTGACTTTAAGACAATGACGAAGATTAAAGCTTAAGGGAAAAAAATAAAAGATAAA CATCTGAAAGCAGCACCAGATCCTTCACTTGCAAATAAGGCTAGTCCAGTTTAATCTTCT TGGTATCCTCTCTACTTTTTAACATTTTTCCTTACTAATCCATATATTTAATTTCATGTC ATATTGGATTTAATCAGACTTTAAAAATTTTCCCTTTAATACCCATATTTAGGCATTAGA TATATAGAATATGTATCTATATATAAATATATCTCTATCGCCCATCCTGCTTATATTTGA CTGAAAAACACAACCACCAAAATGGACAGTTCAGCAAAAGCGCGTTGTCTGTAATTCTCT GGTGTTGCTTCTGGGCAAACCCTAAGTGATGGTGGAGAATCTAACAGTTCGTTAGGTCTG TACTCTGCTTCTAAAACCAGAATCATTTAGTTTGAAATCTATCTGTAAAGTCATGGAGAT TTTTTTCAGCATAAACTCAACAATTTGAGGATGTTTATGAAAAAGAAAAACAGCAAGTTT ACCTCATTGAAAGAGGTGNAGGGAGAGACAGTACTGATTAACCTAAACTCCCCTTTCACT CCCTCAGGTACAGGCTTTTGAGACGTAAATCAAGTCGACATAGCCTGGGG
Restriction Sites	NotI-NotI
ACCN	AK094666
Insert Size	2700 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	AK094666.1
RefSeq Size	2666 bp
RefSeq ORF	2666 bp
Locus ID	4040
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Wnt signaling pathway
Gene Summary	This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

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