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NFAT2 (NFATC1) (NM_172390) Human Untagged Clone
CAT＃: SC101076
NFATC1 (untagged)-Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1
CNY 7,880.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NF-ATC; NF-ATc1.2; NFAT2; NFATc |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC101076 sequence for NM_172390 edited (data generated by NextGen Sequencing)
ATGCCAAGCACCAGCTTTCCAGTCCCTTCCAAGTTTCCACTTGGCCCTGCGGCTGCGGTC TTCGGGAGAGGAGAAACTTTGGGGCCCGCGCCGCGCGCCGGCGGCACCATGAAGTCAGCG GAGGAAGAACACTATGGCTATGCATCCTCCAACGTCAGCCCCGCCCTGCCGCTCCCCACG GCGCACTCCACCCTGCCGGCCCCGTGCCACAACCTTCAGACCTCCACACCGGGCATCATC CCGCCGGCGGATCACCCCTCGGGGTACGGAGCAGCTTTGGACGGTGGGCCCGCGGGCTAC TTCCTCTCCTCCGGCCACACCAGGCCTGATGGGGCCCCTGCCCTGGAGAGTCCTCGCATC GAGATAACCTCGTGCTTGGGCCTGTACCACAACAATAACCAGTTTTTCCACGATGTGGAG GTGGAAGACGTCCTCCCTAGCTCCAAACGGTCCCCCTCCACGGCCACGCTGAGTCTGCCC AGCCTGGAGGCCTACAGAGACCCCTCGTGCCTGAGCCCGGCCAGCAGCCTGTCCTCCCGG AGCTGCAACTCAGAGGCCTCCTCCTACGAGTCCAACTACTCGTACCCGTACGCGTCCCCC CAGACGTCGCCATGGCAGTCTCCCTGCGTGTCTCCCAAGACCACGGACCCCGAGGAGGGC TTTCCCCGCGGGCTGGGGGCCTGCACACTGCTGGGTTCCCCGCGGCACTCCCCCTCCACC TCGCCCCGCGCCAGCGTCACTGAGGAGAGCTGGCTGGGTGCCCGCTCCTCCAGACCCGCG TCCCCGTGCAACAAGAGGAAGTACAGCCTCAACGGCCGGCAGCCGCCCTACTCACCCCAC CACTCGCCCACGCCGTCCCCGCACGGCTCCCCGCGGGTCAGCGTGACCGACGACTCGTGG TTGGGCAACACCACCCAGTACACCAGCTCGGCCATCGTGGCCGCCATCAACGCGCTGACC ACCGACAGCAGCCTGGACCTGGGAGATGGCGTCCCTGTCAAGTCCCGCAAGACCACCCTG GAGCAGCCGCCCTCAGTGGCGCTCAAGGTGGAGCCCGTCGGGGAGGACCTGGGCAGCCCC CCGCCCCCGGCCGACTTCGCGCCCGAAGACTACTCCTCTTTCCAGCACATCAGGAAGGGC GGCTTCTGCGACCAGTACCTGGCGGTGCCGCAGCACCCCTACCAGTGGGCGAAGCCCAAG CCCCTGTCCCCTACGTCCTACATGAGCCCGACCCTGCCCGCCCTGGACTGGCAGCTGCCG TCCCACTCAGGCCCGTATGAGCTTCGGATTGAGGTGCAGCCCAAGTCCCACCACCGAGCC CACTACGAGACGGAGGGCAGCCGGGGGGCCGTGAAGGCGTCGGCCGGAGGACACCCCATC GTGCAGCTGCATGGCTACTTGGAGAATGAGCCGCTGATGCTGCAGCTTTTCATTGGGACG GCGGACGACCGCCTGCTGCGCCCGCACGCCTTCTACCAGGTGCACCGCATCACAGGGAAG ACCGTGTCCACCACCAGCCACGAGGCCATCCTCTCCAACACCAAAGTCCTGGAGATCCCA CTCCTGCCGGAGAACAGCATGCGAGCCGTCATTGACTGTGCCGGAATCCTGAAACTCAGA AACTCCGACATTGAACTTCGGAAAGGAGAGACGGACATCGGGAGGAAGAACACACGGGTA CGGCTGGTGTTCCGCGTTCACGTCCCGCAACCCAGCGGCCGCACGCTGTCCCTGCAGGTG GCCTCCAACCCCATCGAATGCTCCCAGCGCTCAGCTCAGGAGCTGCCTCTGGTGGAGAAG CAGAGCACGGACAGCTATCCGGTCGTGGGCGGGAAGAAGATGGTCCTGTCTGGCCACAAC TTCCTGCAGGACTCCAAGGTCATTTTCGTGGAGAAAGCCCCAGATGGCCACCATGTCTGG GAGATGGAAGCGAAAACTGACCGGGACCTGTGCAAGCCGAATTCTCTGGTGGTTGAGATC CCGCCATTTCGGAATCAGAGGATAACCAGCCCCGTTCACGTCAGTTTCTACGTCTGCAAC GGGAAGAGAAAGCGAAGCCAGTACCAGCGTTTCACCTACCTTCCCGCCAACGGTAACGCC ATCTTTCTAACCGTAAGCCGTGAACATGAGCGCGTGGGGTGCTTTTTCTAA Clone variation with respect to NM_172390.1 786 t=>g >OriGene 5' read for NM_172390 unedited
NGAAGGAAAAAGGCCCAACACCACCCCTTATACANNNNGTTTTTACACCCGCCCGTACCC GCATAGGGCGGTAGGCGTGTCCGGTGGNGAGTCTATATAAGCAGAGCTCATTTAGGTGAC ACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGAACT CGCCGGCGGAGTCGCCGCGCCAGATCCCAGCAGCAGGGCGCGGGCACCGGGGCGCGGGCA GGGCTCGGAGCCACCGCGCAGGTCCTAGGGCCGCGGCCGGGCCCCGCCACGCGCGCACAC GCCCCTCGATGACTTTCCTCCGGGGCGCGCGGCGCTGAGCCCGGGGCGAGGGCTGTCTTC CCGGAGACCCGACCCCGGCAGCGCGGGGCGCCCGCTTCTCCTGTGCCTCCGCCCGCCGCT CCACTCCCCGCCGCCGCCGCGCGGATGCCAAGCACCAGCTTTCCAGTCCCTTCCAAGTTT CCACTTGGCCCTGCGGCTGCGGTCTTCGGGAGAGGAGAAACTTTGGGGCCCGCGCCGCGC GCCGGCGGCACCATGAAGTCAGCGGAGGAAGAACACTATGGCTATGCATCCTCCAACGTC AGCCCCGCCCTGCCGCTCCCCACGGCGCACTCCACCCTGCCGGCCCCGTGCCACAACCTT CAGACCTCCACACCGGGCATCATCCCGCCGGCGGATCACCCCTCGGNGTACGGAGCAGCT NTGGACGGTGGGCCCGCGGGCTACTTCCTCTCCTCCGGCCACACCAGGCCTGATGGNGCC CCTGCCCTGGAGAGTCCTCGCATCGAGATAACCTCGTGCTTGGGCCTGTACCACAACAAT AACCAGTTNTTCCACGATGTGGNAGGTGGGAGACGTCCTCCCTAGCTCCAAACGGTCCCC CTCCACGGCCACGCTGAATCTGCCCAA >OriGene 3' read for NM_172390 unedited
GAAAATCAGGTACCGTGCCGCAATCGAGGATTNGTTTTTTTTCTTTTTTTTTAAAAGCAA AGTTTATTCCTAAAGTGCCTGCAAAATAGCTATACCTATTTGCCTTTTCACCGTAAGCAG CTTTAGGGTGCAAATGCACACCAGGACCCCCTCAGTTTTTTGGAGCAGAAGAGCCATGTT TTCCCCTTGGCTGTTATACATTCGCAAGAAGCAAAATATCCGTGACTATCTGAGTATGCA ACCCCCGCCCCCCACCCCCAACAGGGATCAAGGAAAATGCATCCGAAGCTTCCCTTTTCC TTTCCTTTTCAGGGCATCGATGGCTCGGTCTCACTAACGGGACATCACACAGTTAAATGT GCAACACGCCACGCTGCTTTACGGCGACGTCGTTTCTGCGTCTTTAGAAAAAGCACCCCA CGCGCTCATGTTCACGGCTTACGGTTAGAAAGATGGCGTTACCGTTGGCGGGAAGGTAGG TGAAACGCTGGTACTGGCTTCGCTTTTTCTTCCCGTTGCAGACGTAGAAACTGACGTGAA CGGGGCTGGGTATCCTCTGATTCCGAAATGGCGGGATCTCAACCACCAGAGAATTCCGCT TGCACAAGGCCCGGGAAGTTTTCGCTTTCATCTCCCAGACATGGTGGCCATCTGGGGGCT TTCTCACGAAAAATACCCTTGGAGTCCTCGCAGAAAGTTTTGGGCAGAAAAGACCATTTT CTTTCCGCCCACGACCGGATAGCTGGCCGTGCTTTTGTTTTTCCACCAAAGCAGCTTCCT GGACTTGAGCCTGGGAGCATTCGTTGGGGGTTGGAGGCCCCTCTGTGGGACAACTTTCCG GCCCTTGTGTTGCGGGACCTTTACACCGGAAAACCAGCCGTCCCCGGGGGTTTTTTTTTC CGATTGGGGTTTTTCTTTTCCAAGATAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_172390 |
| Insert Size | 2300 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_172390.1, NP_765978.1 |
| RefSeq Size | 3140 bp |
| RefSeq ORF | 2151 bp |
| Locus ID | 4772 |
| UniProt ID | O95644 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Axon guidance, B cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway |
| Gene Summary | The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] Transcript Variant: This variant (1) lacks two exons and its transcription extends past a splice site that is used in variant 6, which results in a novel 3' coding region and 3' UTR, compared to variant 6. The encoded isoform (A) is shorter and has a distinct C-terminus, compared to isoform F. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
p38a Protein Negatively Regulates T Helper Type 2 Responses by Orchestrating Multiple T Cell Receptor-associated Signals
,Ping Hu, Angel R. Nebreda, Yan Liu, Nadia Carlesso, Mark Kaplan, and Reuben Kapur,
J. Biol. Chem., Sep 2012; 287: 33215 - 33226.
[NFATC1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC211136 | NFATC1 (Myc-DDK-tagged)-Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1 |
CNY 7,864.00 |
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| RC211136L1 | Lenti ORF clone of Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1, Myc-DDK-tagged |
CNY 10,264.00 |
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| RC211136L2 | Lenti ORF clone of Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1, mGFP tagged |
CNY 10,264.00 |
|
| RC211136L3 | Lenti ORF clone of Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1, Myc-DDK-tagged |
CNY 10,264.00 |
|
| RC211136L4 | Lenti ORF clone of Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1, mGFP tagged |
CNY 7,700.00 |
|
| RG211136 | NFATC1 (tGFP-tagged) - Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant 1 |
CNY 9,464.00 |
