Piezo1 (NM_001077200) Rat Tagged ORF Clone

Specifications

Product Data
Type	Rat Tagged ORF Clone
Tag	Myc-DDK
Synonyms	Fam38a; Mib
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >RR212770 representing NM_001077200 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCCGCACGTGCTGGGCGCCGGGCTCTACTGGCTGTTGCTACCCTGCACACTCCTGGCGGCCTCCC TGTTACGCTTCAATGCTCTCTCGTTGGTCTATTTGCTGTTTCTACTGCTGCTACCCTGGCTTCCAGGCCC CTCAAGACACAGCATACCAGGTCACACAGGTCGCCTGCTTCGTGCACTACTCTGCCTCAGCCTCCTCTTC CTGGTGGCCCATGTTGCCTTCCAGATATGCCTACATACCATGCCTCGCCTGAACCAGCTTCTGGGACAAA ACTGTAACCTTTGGGCAAACGTGTCTCAACACATAGGGGTTACAAGGCTGGACCTGAAGGACATCTTTAA CACCACCAGACTGGTGGCACCTGACCTGGGAGTGCTGGTGGCATCTTCCCTTTGCCTTGGCCTCTGTGGA CGCCTCACAAGGAAAGCCCGGCAGAGCCAGCGCACTCAGGAGCTGGAGGAGGATGACATAGATGCTGCCC CCGCCGCAGGGCTGCAGGGAGCCCCCACCCTGGCAACCAAACGCAGGCTGTGGCTGGCCCCTCGCTTCCG GATCACGGCGCACTGGCTGCTGGTGACCTCCGGACGGATGCTGGTCATCGTGCTACTGGCACTCGCAGGC ATAGCCCATCCTTCGGCCTTCTCCAGCGTCTACCTGATGGTGTTCCTGGCCATCTGCACCTGGTGGTCTT GCCACTTTCCTCTCAGCTCCCTGGGCTTTAACACCCTCTGCGTCATGGTGAGCTGCTTTGGCGCCGGCCA TCTTGTTTGTTTATACTGCTATCAGACACCATTTGTCCAGAGCGTGCTACTTCCTGGCAGCCTCTGGGCC AGGCTATTTGGTCTCAAGAACTTCGTAGACATCCCTAACTGCTCCAGCCCCAACGTGCTGGTACTCAACA CTAAGCATGCTTGGCCCATCTACGTGAGCCCCGGTATCCTGCTGCTGTTGTACTACACAGCCACCTCTCT CCTGAAGCTCCGCAAGGGCCGCTTCTCAGAGCTGAGGAAGGAGATCCCGAGGGAGGATGAGGAGCATGAA CTGGAACTGGACCAGCTGGAGCCAGAGCCCCAGGCTAGGGGCACCACCCAGGGTGCGACGCCCACGACCA CTGGACCCGACATTGACAACTGCACCGTGCATGTACTAACCAGCCAGAGCCCCGTCCGCCAGCGTCCTGT ACGCCCCAGGCTGGCTGAGCTGAAAGAGATGTCACCACTACATGGCCTGGGCCACCTCATCCTGGACCAG AGCTATGTGTGTGCTCTGATCGCCATGATGGTGTGGAGCATCATGTACCACAGCTGGCTGACCTTCGTCT TGCTGCTCTGGGCCTGCCTCATCTGGACCGTGCGCAGCCGCCACCAGTTGGCTATGCTGTGCTCACCCTG CATCCTGCTGTACGGACTGACACTCTGCTGCCTGCGGTACGTGTGGGCCATGGAGCTCCCCGAGCTGCCC ACCACCCTGGGCCCTGTCAGTCTACATCAGTTGGGATTGGAGCATACACGCTACCCCTGCCTGGACCTTG GTGCCATGCTGCTGTATCTGCTCACGTTCTGGCTGCTCCTGCGTCAGTTCGTGAAGGAGAAGCTGCTGAA GAAGAGAAAGGCACCTTCGACGCTGCTGGAGGTCACAGTGTCCGACACAGAGCCCACACAGACCCAGACA CTGCTGAGGAGCCTGGGGGAGCTGGTCACGGGCATCTACGTCAAGTACTGGATCTACGTGTGCGCTGGGA TGTTCATTGTGGTCAGCTTCGCTGGCCGCCTGGTGGTCTACAAAATCGTCTACATGTTCCTTTTCCTGCT GTGCCTCACGTTGTTCCAGGTCTACTACACTCTGTGGAGGAAGCTGCTCCGAGTTTTCTGGTGGCTCGTG GTGGCCTACACCATGCTCGTGCTCATCGCCGTGTACACTTTCCAGTTCCAGGACTTCCCCACCTACTGGC GCAACCTCACGGGCTTCACAGATGAACAGTTGGGCGACCTGGGCCTGGAGCAGTTCAGCGTGTCGGAGCT CTTTTCCAGCATCCTCATCCCTGGCTTCTTCCTGCTGGCCTGCATCCTGCAGCTGCACTACTTCCACAGG CCGTTCATGCAGCTCACCGACCTGGAGCACGTGCCCCCGCCAGGCACACGCCGCCTTCGCTGGGCTCACA GGCAGGATACAGTGAGCGAGGCCCCTCTGCTTCAGCATCAGGAGGAGGAGGAAGTCTTCAGGGATGACGG GCAGAGCATGGATGGGCCCCACCAGACCACACAGGTCCCTGAGGGTACAGCCAGCAAGTGGGGCCTGGTG GCCGACCGGCTGCTGGACCTAGCGTCCAGCTTCTCCGCCGTCCTCACCCGCATCCAGGTGTTCGTACGAT GTTTGCTCGAGCTTCACGTCTTCAAGCTGGTGGCTCTCTACACTGTCTGGGTGGCCCTGAAAGAAGTGTC CGTGATGAACCTGCTGCTGGTGGTGCTGTGGGCCTTCGCCCTGCCCTACCCGCGCTTCCGGCCCATGGCC TCCTGCCTGTCCACCGTGTGGACCTGTATCATCATCGTGTGCAAGATGCTGTATCAGCTGAAGATTGTCA ACCCACACGAGTACTCCAGTAACTGCACCGAGCCCTTTCCCAACAATACCAACTTGCAGCCCTTGGAGAT CAGCCAGTCTCTGCTGTACCGTGGCCCCGTTGACCCTGCCAACTGGTTTGGGGTGCGGAAGGGTTACCCA AACTTGGGCTATATCCAGAACCACCTGCAGATCCTTCTGCTGCTGGTGTTTGAGGCTGTGGTGTACCGGC GCCAAGAGCACTACCGCCGGCAGCACCAGCAGGCCCCTCTGCCCGCCCAGGCTTTGTGCGCTGATGGCAC CCGCCAGAGGCTGGACCAGGACCTACTCAGCTGCCTCAAATATTTCATCAACTTCTTCTTCTACAAATTC GGGCTGGAGATCTGCTTCTTGATGGCCGTGAATGTCATCGGACAACGCATGAACTTCATGGTGATCTTAC ACGGCTGCTGGTTGGTGGCCATCCTTACACGCCGGCGCCGTGAGGCCATCGCCCGCCTCTGGCCCAATTA CTGTCTGTTCCTCACGCTGTTCCTGCTGTACCAGTACCTGCTGTGCCTGGGCATGCCTCCCGCACTGTGC ATCGACTACCCGTGGCGCTGGAGCCAGGCCATCCCCATGAATTCTGCGCTCATCAAGTGGCTGTACCTCC CTGACTTCTTCAGGGCCCCCAACTCCACCAACCTTATCAGTGACTTCCTCCTGCTACTCTGCGCCTCCCA ACAGTGGCAGGTGTTCTCCGCAGAGCAAACGGAAGAATGGCAGCGCATGGCTGGCGTTAACACTGACCAC CTGGAGCCCCTGCGTGGGGAGCCCAACCCTATCCCCAACTTCATCCACTGCAGGTCCTATCTGGATATGC TGAAGGTGGCCGTCTTCCGCTACCTGTTCTGGCTGGTGCTGGTGGTCGTGTTTGTCACAGGGGCCACCCG CATCAGCATCTTTGGGCTGGGGTACCTGCTGGCCTGCTTCTACCTGCTGCTCTTTGGCACCACCCTGCTG CAGAAGGACACACGAGCCCAGCTCGTGCTGTGGGACTGCCTCATCCTCTACAACGTCACCGTCATCATCT CTAAGAATATGTTGTCGCTCCTGTCCTGTGTCTTCGTGGAGCAAATGCAGAGCAACTTCTGCTGGGTCAT CCAGCTCTTCAGCCTCGTGTGCACAGTCAAAGGCTACTATGACCCCAAAGAGATGAAGACCAGGGACCGG GATTGCCTGCTGCCTGTGGAGGAGGCCGGGATCATCTGGGACAGCATCTGCTTCTTCTTCCTGCTCCTAC AACGGCGCGTCTTTCTCAGCCACTACTTCCTGCACGTCAGTGCTGACCTGAAGGCCACGGCCCTGCAGGC CTCCAGGGGTTTTGCTCTCTACAATGCGGCCAACATAAAGAACATCAACTTCCACCGTCAGACCGAGGAG AGGTCCCTGGCCCAGCTGAAAAGACAGATGAAGCGCATCCGTGCCAAACAGGAGAAATACCGGCAGAGCC AGGCAAGCCGTGGTCAACTCCAGTCCACAGACCCTCAGGAGCCAGGGCCTGACAGCCCAGGGGGTTCCTC CCCGCCACGGACACAGTGGTGGCGCCCCTGGCAGGACCACGCCACAGTCATCCACTCTGGTGACTACTTC CTGTTTGAGTCGGACAGTGAGGAGGAAGAGGAGGCCCTGCCTGAGGACCCCAGGCCTGCAGCTCAGAGTG CCTTCCAGATGGCATACCAGGCATGGGTAACCAACGCCCAGACAGTGCTAAGGCAGCGTCGTGAACAGGC ACGGCGGGATCGGGCAGAACAGCTGGCTTCTGGAGGCGACTTGAGTCCTGAGGTGGAGCTGGTAGACGTC CCAGAGAATGAGATGGCAGGCCATAGCCATGTGATGCAGCGCGTGCTGAGTACCATGCAGTTCCTGTGGG TGCTGGGCCAGGCCACAGTGGACGGGCTGACGCGCTGGTTGCGTACGTTCACGAAGGACCACCGCACCAT GAGTGATGTGCTGTGTGCAGAGCGTTACCTGCTCACCCAGGAGCTTCTTCGGGGTGGAGAGGTACACCGA GGGGTACTGGACCAGCTTTACGTGAGCGAAGATGAGATCGCACTGTCAGGTCCTGTGGAGAACCGTGATG GACCCAGCACAGCCTCTAGCGGGCTGGGAGCTGAAGAGCCTTTGAGTAGCATGACAGACGACACCGGCAG CCCCCTTAGCACTGGCTACAACACTCGCAGTGGTAGTGAGGAGATTATCACCGACACTGGGGGCCTCCAG GCTGGGACCTCCCTGCACGGCTCCCAAGAGCTTCTAGCCAATGCTCGTACCCGGATGCGCACAGCCAGTG AGCTGCTGCTGGACAGGCGCCTGCGTATCCCTGAGCTGGAGGAGGCCGAGCAGTTTGAGGCACAGCAGGG CCGGACGCTGCGGCTGCTCAGAGCCATGTACCAGTGTGTGGCGGCCCACTCAGAGCTTCTCTGTTACTTC ATCATCATCCTTAACCACATGGTGACAGCCTCGGCTGCCTCCCTGGTGCTGCCTGTGCTTGTGTTCCTCT GGGCCATGCTGACCATCCCGAGGCCTAGCAAGCGCTTCTGGATGACAGCTATCGTCTTCACTGAGGTCAT GGTGGTCACCAAATACTTGTTCCAGTTTGGCTTCTTCCCCTGGAACAGCTACATAGTGCTTCGACGCTAC GAGAACAAGCCCTACTTCCCTCCGCGCATCCTGGGCCTCGAGAAAACAGACAGCTATATCAAGTACGACC TGGTGCAACTCATGGCCCTCTTCTTCCACCGCTCGCAGTTACTGTGCTATGGCCTCTGGGACCATGAGGA GGATGGTGTCCCCAAGGACCATTGCAGGAGTAGCGAAAAGGACCAGGAAGCTGAGGAAGAGTCAGAGGCT AAGCTGGAATCGCAGCCTGAGACGGGCACTGGGCATCCTGAGGAGCCCGTGTTGACTGGTACCCCCAAGG ACCACATCCAAGGGAAAGGAAGTGTTAGGTCCAAGGATGAGATCCAAGATCCCCCAGAGGACCTTAAGCC CCAGCACAGGAGACACATCAGCATACGCTTCAGGAGGAGGAAGGAGACTCAAGGACCCAAAGGAGCAGCA GTCGTGGAGGCTGAGCACGAGGAGGGAGAGGAAGGAAGAGAAGCTGCAGGGAGAAAGAGGCTGCGTCGCC CTCGAGAAGGGTTGAAGATTCGGGAGAAAATGAAGGCAGCTGGACGCCGGCTGCAGAGCTTCTGTCTGTC ACTGGCCCAGAGCTTTTACCAACCCCTGCGGCGTTTCTTCCATGACATTCTGCACACCAAGTACCGAGCG GCCACCGACGTCTATGCCCTCATGTTCCTGGCTGACATTGTCGACATTGTCGTCATCATCTTCGGTTTTT GGGCTTTTGGGAAGCACTCCGCGGCCACGGACATTGCATCCTCACTGTCAGATGACCAGGTGCCACAGGC CTTCCTGTTCATGCTGCTGGTCCAGTTCGGCACCATGGTCATAGACCGCGCCCTCTACCTGCGTAAGACT GTACTGGGCAACCTGGCCTTTCAGGTGGTCCTGGTGGTGGCCATTCACCTCTGGATGTTTTTCATCTTAC CGGCTGTCACCGAGAGGATGTTCAGACAGAACGCGGTGGCCCAGCTGTGGTACTTCGTGAAGTGCATTTA CTTTGCCCTGTCCGCCTACCAGATCCGCTGTGGCTACCCCACCCGTATCTTGGGCAACTTCCTCACCAAG AAGTACAATCATCTAAACCTCTTCCTTTTCCAGGGGTTCCGTCTAGTGCCATTCCTGGTGGAGCTGCGGG CCGTCATGGACTGGGTATGGACTGACACCACGCTGTCCCTGTCCAACTGGATGTGTGTGGAAGACATCTA TGCCAACATCTTTATCATCAAGTGCAGCCGAGAGACAGAGAAGAAATACCCCCAGCCCAAGGGACAGAAG AAGAAGAAAATCGTCAAGTATGGCATGGGAGGTCTCATCATCCTCTTCCTCATTGCCATCATCTGGTTCC CTCTGCTCTTCATGTCACTGATCCGCTCTGTGGTTGGTGTCGTCAACCAGCCCATTGATGTCACTGTTAC CCTCAAGTTAGGTGGCTACGAGCCACTGTTCACCATGAGCGCCCAGCAGCCATCCATAGTGCCATTCACT CCCGAGGACTATGAGGAGCTGTCCCAGCAGTTTGACCCCTACCCACTAGCCATGCAGTTCATTAGCCAGT ACAGTCCTGAGGACATCGTCACTGCACAGATTGAGGGCAGCTCGGGGGCCCTGTGGCGCATCAGCCCGCC CAGCCGGGCCCAGATGAAGCACGAGCTGTACAACGGCACAGCCGACATCACACTGCGCTTCACCTGGAAT TTCCAAAGGGACCTGGCCAAGGGCGGCTCTGTGGAGTATACCAACGAGAAGCACACCTTGGAGCTGGCCC CCAACAGTACGGCACGAAGGCAGCTGGCCCAACTGCTCGAGGGCAGACCTGACCAGTCAGTGGTCATTCC CCACCTCTTCCCCAAGTACATTCGTGCACCCAATGGGCCTGAAGCCAATCCTGTGAAGCAACTGCAGCCA GACGAGGAAGAGGACTACCTTGGTGTGCGTATCCAGCTGCGGAGAGAGCAAGTGGGCACAGGAACCTCTG GGGAGCAAGCAGGCACAAAGGCCTCCGACTTCCTCGAGTGGTGGGTGATTGAGCTGCAGGACTGCCAGGC CGAGTGCAACCTGCTGCCCATGGTCATCTTCAGTGACAAGGTCAGCCCGCCTAGCCTGGGCTTCCTGGCC GGCTACGGGATTGTGGGGCTCTACGTCTCTATCGTGCTGGTCGTTGGCAAGTTTGTGCGGGGCTTCTTCA GTGATATCTCACACTCCATCATGTTCGAGGAGCTGCCGTGCGTGGACCGCATCCTCAAGCTGTGCCAGGA CATCTTCTTGGTACGGGAGACCCGCGAGCTGGAGCTGGAGGAGGAACTCTATGCCAAGCTCATATTCCTG TACCGATCACCAGAGACCATGATCAAGTGGACGCGTGAGAAGGAG AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >RR212770 representing NM_001077200 Red=Cloning site Green=Tags(s) MEPHVLGAGLYWLLLPCTLLAASLLRFNALSLVYLLFLLLLPWLPGPSRHSIPGHTGRLLRALLCLSLLF LVAHVAFQICLHTMPRLNQLLGQNCNLWANVSQHIGVTRLDLKDIFNTTRLVAPDLGVLVASSLCLGLCG RLTRKARQSQRTQELEEDDIDAAPAAGLQGAPTLATKRRLWLAPRFRITAHWLLVTSGRMLVIVLLALAG IAHPSAFSSVYLMVFLAICTWWSCHFPLSSLGFNTLCVMVSCFGAGHLVCLYCYQTPFVQSVLLPGSLWA RLFGLKNFVDIPNCSSPNVLVLNTKHAWPIYVSPGILLLLYYTATSLLKLRKGRFSELRKEIPREDEEHE LELDQLEPEPQARGTTQGATPTTTGPDIDNCTVHVLTSQSPVRQRPVRPRLAELKEMSPLHGLGHLILDQ SYVCALIAMMVWSIMYHSWLTFVLLLWACLIWTVRSRHQLAMLCSPCILLYGLTLCCLRYVWAMELPELP TTLGPVSLHQLGLEHTRYPCLDLGAMLLYLLTFWLLLRQFVKEKLLKKRKAPSTLLEVTVSDTEPTQTQT LLRSLGELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLV VAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGFFLLACILQLHYFHR PFMQLTDLEHVPPPGTRRLRWAHRQDTVSEAPLLQHQEEEEVFRDDGQSMDGPHQTTQVPEGTASKWGLV ADRLLDLASSFSAVLTRIQVFVRCLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMA SCLSTVWTCIIIVCKMLYQLKIVNPHEYSSNCTEPFPNNTNLQPLEISQSLLYRGPVDPANWFGVRKGYP NLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHQQAPLPAQALCADGTRQRLDQDLLSCLKYFINFFFYKF GLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALC IDYPWRWSQAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAEQTEEWQRMAGVNTDH LEPLRGEPNPIPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTTLL QKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYDPKEMKTRDR DCLLPVEEAGIIWDSICFFFLLLQRRVFLSHYFLHVSADLKATALQASRGFALYNAANIKNINFHRQTEE RSLAQLKRQMKRIRAKQEKYRQSQASRGQLQSTDPQEPGPDSPGGSSPPRTQWWRPWQDHATVIHSGDYF LFESDSEEEEEALPEDPRPAAQSAFQMAYQAWVTNAQTVLRQRREQARRDRAEQLASGGDLSPEVELVDV PENEMAGHSHVMQRVLSTMQFLWVLGQATVDGLTRWLRTFTKDHRTMSDVLCAERYLLTQELLRGGEVHR GVLDQLYVSEDEIALSGPVENRDGPSTASSGLGAEEPLSSMTDDTGSPLSTGYNTRSGSEEIITDTGGLQ AGTSLHGSQELLANARTRMRTASELLLDRRLRIPELEEAEQFEAQQGRTLRLLRAMYQCVAAHSELLCYF IIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYIVLRRY ENKPYFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWDHEEDGVPKDHCRSSEKDQEAEEESEA KLESQPETGTGHPEEPVLTGTPKDHIQGKGSVRSKDEIQDPPEDLKPQHRRHISIRFRRRKETQGPKGAA VVEAEHEEGEEGREAAGRKRLRRPREGLKIREKMKAAGRRLQSFCLSLAQSFYQPLRRFFHDILHTKYRA ATDVYALMFLADIVDIVVIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLRKT VLGNLAFQVVLVVAIHLWMFFILPAVTERMFRQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTK KYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQK KKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFT PEDYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKHELYNGTADITLRFTWN FQRDLAKGGSVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQP DEEEDYLGVRIQLRREQVGTGTSGEQAGTKASDFLEWWVIELQDCQAECNLLPMVIFSDKVSPPSLGFLA GYGIVGLYVSIVLVVGKFVRGFFSDISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFL YRSPETMIKWTREKE SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-RsrII      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001077200
ORF Size	7605 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001077200.2, NP_001070668.2
RefSeq Size	8221 bp
RefSeq ORF	7608 bp
Locus ID	361430
UniProt ID	Q0KL00
MW	290.3 kDa
Gene Summary	Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.[UniProtKB/Swiss-Prot Function]

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