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Fbxo11 (NM_181631) Rat Untagged Clone
CAT＃: RN214960
Fbxo11 (untagged ORF) - Rat F-box protein 11 (Fbxo11), (10 ug)
CNY 10,740.00
Product images
Specifications
| Product Data | |
| Type | Rat Untagged Clone |
| Tag | Tag Free |
| Synonyms | Vit1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RN214960 representing NM_181631
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGTTGCAGAAGAATCAGGTCCTGGTGCACAAAACAGTCCATACCAGCTTCGTAGAAAAACTCTTTTGC CAAAAAGAACAGCGTGTCCTACAAAGAACAGCATGGAGGGCGCCTCTACTTCAACTACAGAAAACTTCGG CCATCGAGCGAAGCGGGCAAGAGTGTCTGGGAAGTCACAAGATCTGTCAGCAGCACCCGCTGAACAGTAT CTTCAGGAGAAGCTACCAGATGAAGTAGTTTTAAAAATATTCTCTTATTTGCTGGAACAAGATCTTTGTA GAGCTGCTTGTGTGTGTAAACGCTTCAGTGAACTTGCTAATGATCCAATTTTGTGGAAACGATTATATAT GGAAGTATTTGAATATACCCGGCCTATGATGCATCCTGAACCTGGTAAATTCTACCAGATTAATCCAGAA GAATATGAACATCCAAATCCATGGAAAGAGAGTTTTCAACAGTTGTATAAAGGTGCACACGTAAAGCCGG GATTTGCGGAACATTTCTATAGTAATCCTGCCAGATACAAAGGGAGAGAAAACATGTTGTATTATGATAC TATTGAAGATGCCCTTGGCGGAGTACAAGAAGCACATTTTGATGGGCTTATCTTTGTTCATTCTGGAATA TATACTGATGAATGGATATATATTGAATCTCCAATCACTATGATTGGTGCAGCACCTGGGAAGGTTGCAG ACAAGGTCATCATTGAGAACACTAGAGACTCCACTTTCGTTTTTATGGAAGGTTCTGAGGACGCTTACGT TGGATATATGACAATAAGATTCAACCCTGATGACAAATCTGCCCAGCATCACAACGCGCACCACTGCCTA GAGATCACAGTCAACTGCAGCCCCATTATCGACCACTGTATCATCCGAAGCACATGCACAGTTGGCTCTG CAGTGTGTGTCAGCGGTCAGGGGGCGTGTCCCACTATCAAGCATTGTAACATCAGTGACTGTGAAAACGT CGGCCTCTATATAACAGATCATGCACAGGGAATATATGAAGATAATGAAATTTCTAATAATGCATTAGCT GGGATTTGGGTTAAAAATCATGGAAATCCAATTATTAGACGGAATCACATTCATCATGGACGTGATGTTG GTGTATTCACATTTGATCATGGCATGGGCTACTTTGAAAGTTGCAACATACACAGAAACAGGATAGCAGG CTTTGAGGTAAAAGCCTACGCTAATCCCACAGTGGTTCGATGTGAAATTCACCATGGGCAGACTGGAGGA ATATATGTCCATGAGAAAGGAAGAGGACAATTTATAGAGAATAAAATCTATGCAAACAACTTCGCAGGCG TATGGATTACCTCAAATAGTGACCCAACAATAAGGGGGAATTCTATATTTAATGGAAATCAAGGAGGAGT TTACATCTTTGGTGATGGACGAGGCCTTATAGAAGGAAATGACATTTATGGTAATGCGTTAGCAGGAATT CAGATTAGGACAAACAGTTGTCCTATTGTTCGACATAACAAAATTCACGATGGACAGCATGGTGGGATTT ATGTGCATGAAAAGGGACAAGGTGTAATAGAAGAAAATGAAGTTTACAGCAACACCCTGGCTGGCGTCTG GGTGACAACTGGCAGCACGCCAGTACTAAGAAGAAATCGGATACACAGTGGCAAGCAGGTCGGTGTTTAT TTCTATGACAATGGACATGGTGTTCTAGAAGATAACGATATCTACAATCATATGTATTCAGGGGTTCAGA TAAGGACTGGAAGCAACCCCAAAATTAGAAGAAACAAAATTTGGGGAGGACAAAATGGTGGAATTCTAGT TTATAATTCTGGTCTAGGCTGTATAGAAGACAATGAAATCTTCGACAACGCAATGGCTGGCGTCTGGATT AAAACAGACAGCAATCCTACGCTGAGACGGAATAAAATCCACGATGGAAGGGATGGCGGCATCTGTATAT TTAATGGGGGTCGAGGTCTCCTTGAAGAAAATGATATTTTCAGGAACGCTCAAGCAGGTGTTCTTATCAG CACCAACAGTCATCCAGTCTTAAGAAAAAACAGAATATTCGATGGATTTGCTGCAGGTATTGAAATTACA AATCATGCAACTGCAACACTAGAAGGCAATCAGATTTTTAACAACAGATTTGGAGGCTTATTTTTAGCAT CTGGTGTTAACGTGACAATGAAAGATAACAAGATAATGAACAATCAAGATGCCATAGAAAAGGCTGTTAG TAGAGGACAATGTTTATATAAAATATCAAGTTATACCAGCTATCCCATGCATGACTTCTACAGATGTCAT ACTTGTAACACCACAGATCGAAATGCCATATGTGTGAACTGCATTAAGAAGTGCCATCAGGGACATGATG TAGAGTTCATTAGACATGATAGGTTTTTCTGTGACTGTGGTGCTGGAACACTGTCCAATCCTTGTACATT AGCTGGTGAGCCAACACATGATACAGACACACTATATGACTCTGCCCCACCTATAGAGTCTAATACGTTG CAGCACAACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_181631 |
| Insert Size | 2532 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_181631.2, NP_853662.1 |
| RefSeq Size | 3726 bp |
| RefSeq ORF | 2532 bp |
| Locus ID | 301674 |
| UniProt ID | Q7TSL3 |
| Gene Summary | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RR214960 | Fbxo11 (Myc-DDK-tagged ORF) - Rat F-box protein 11 (Fbxo11), (10 ug) |
CNY 10,740.00 |
|
| RR214960L3 | Lenti ORF clone of Fbxo11 (Myc-DDK-tagged ORF) - Rat F-box protein 11 (Fbxo11), (10 ug) |
CNY 12,640.00 |
|
| RR214960L4 | Lenti ORF clone of Fbxo11 (mGFP-tagged ORF) - Rat F-box protein 11 (Fbxo11), (10 ug) |
CNY 13,780.00 |
