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Sarm1 (NM_001105817) Rat Untagged Clone
CAT＃: RN210840
Sarm1 (untagged ORF) - Rat sterile alpha and TIR motif containing 1 (Sarm1), (10 ug)
CNY 9,310.00
Product images
Specifications
| Product Data | |
| Type | Rat Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RN210840 representing NM_001105817
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGTCCTGACGCTGCTCTTCTCCGCCTACAAACTGTGCCGCTTCTTCATCATGTCAGGCCCACGGCCGG GCGCCGATCGGCTGACAGTACCGGGACCGGATCGGAGTGGCGGCACCAGCCCATGGTGGGCTGCGGGCGG TCGCGGGTCTCGCGAAGTGTCGCCCGGGGTGGGCACCGAGGTGCAAGGCGCGCTGGAGCGTTCGCTGCCG GAGCTGCAGCAGGCGCTGTCCGAGCTGAAACAGGCAAGCGCGGCGCAAGCGGTGGGCGCGGGCCTCGCCG AGGTCTTCCAGCTGGTAGAGGAAGCCTGGCTGCTGCCGGCCGTGGGCCGCGAGGTGGCCCAAGGTTTGTG CGATGCTATACGTCTGGACGGTGGCCTCGACTTGCTGTTGCGGCTGCTTCAGGCACCGGAGCTAGAGACC CGCGTGCAGGCCGCGCGCTTGCTGGAGCAGATCCTGGTGGCTGAGAACCGGGACCGCGTAGCGCGCATCG GCCTAGGCGTGATCTTGAACCTGTCGAAGGAACGCGAGCCTGTGGAGCTGGCACGGAGCGTGGCGGGCAT CTTGGAGCACATGTTCAAGCACTCGGAGGAGACCTGCCAGCGGCTGGTGGCGGCCGGAGGCCTCGACGCG GTGCTGTATTGGTGCCGCCGCACAGACCCAGCGCTACTGCGCCACTGCGCGCTGGCGCTGGCAAACTGCG CGCTGCACGGGGGCCAGACTGTGCAGCGGTGCATGGTGGAGAAGCGCGCCGCCGAGTGGCTCTTCCCGCT CGCTTTCTCCAAAGAGGACGAGTTGCTGCGGCTGCATGCTTGCCTGGCGGTGGCCGTGTTGGCTACCAAC AAGGAGGTAGAACGCGAGGTCGAGCACTCAGGCACGTTGGCGCTCGTCGAGCCGCTGGTGGCATCGCTGG ATCCTGGCCGCTTCGCTCGTTGCCTGGTGGATGCCAGTGACACAAGCCAGGGTCGTGGACCAGACGACCT GCAGAGCCTGGTGCTGTTGCTCGATTCGTCGCGTTTGGAGGCTCAGTGCATAGGGGCTTTCTACCTGTGC GCCGAGGCTGCCATCAAAAGCCTACAGGGAAAGACCAAGGTATTCAGCGACATCGGCGCCATCCAGAGCC TGAAACGCCTGGTTTCTTACTCCACAAATGGCACCACGTCGACGCTGGCCAAGCGCGCGCTGCGCCTATT GGGCGAGGAGGTGCCAAGGCGCATCCTACCCTGCGTGGCCAGCTGGAAGGAGGCTGAGGTCCAGACCTGG CTGCAGCAGATCGGCTTCTCCCAGTACTGCGAGAACTTTCGGGATCAGCAGGTAGATGGTGATTTGCTTC TACGACTCACAGATGAAGAACTCCAGACAGACCTAGGCATGAAATCAAGCATCACCCGCAAGAGGTTCTT TAGGGAGCTCACGGAGCTCAAGACCTTCGCCAGCTATGCTACTTGCGACCGCAGCAACCTAGCAGACTGG CTGGGCAGCCTGGATCCTCGCTTCCGCCAGTACACCTATGGCCTGGTCAGCTGCGGCCTGGACCGCTCCC TGCTGCACCGCGTGTCAGAGCAGCAGCTCCTGGAGGACTGTGGCATCCGCCTGGGGGTGCATCGCACGCG CATCCTCTCTGCAGCCAGAGAAATGCTACATTCCCCGCTGCCCTGTACCGGAGGCAAGCCCAGTGGAGAC ACCCCAGATGTCTTTATCAGCTACCGCAGGAACTCGGGTTCCCAGCTGGCCAGCCTCCTGAAGGTGCACC TGCAGCTGCATGGCTTCAGTGTCTTCATCGATGTGGAGAAGCTGGAGGCCGGCAAATTCGAGGACAAGCT CATCCAGAGTGTCATGGCGGCTCGAAATTTTGTGCTGGTGCTGTCTGCGGGAGCGCTGGATAAGTGCATG CAGGACCATGAATGCAAGGACTGGGTGCACAAGGAGATCGTGACTGCCTTAAGCTGTAGCAAGAACATTG TGCCCATCATTGATGGCTTTGAGTGGCCTGAGCCTCAGGCACTGCCTGAGGATATGCAGGCTGTACTCAC CTTCAACGGCATCAAATGGTCTCATGAGTACCAGGAGGCCACCATCGAGAAAATCATCCGCTTCCTACAG GGTCGCCCCTCTCAGGACTCCTCTGCCGGCTCTGACACCAGTTTGGAGGGAGCTACATCAATGGGTCTGC CTTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001105817 |
| Insert Size | 2175 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001105817.1, NP_001099287.1 |
| RefSeq Size | 4039 bp |
| RefSeq ORF | 2175 bp |
| Locus ID | 287545 |
| UniProt ID | D3ZUM2 |
| Gene Summary | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RR210840 | Sarm1 (Myc-DDK-tagged ORF) - Rat sterile alpha and TIR motif containing 1 (Sarm1), (10 ug) |
CNY 5,832.00 |
|
| RR210840L3 | Lenti ORF clone of Sarm1 (Myc-DDK-tagged ORF) - Rat sterile alpha and TIR motif containing 1 (Sarm1), (10 ug) |
CNY 11,120.00 |
|
| RR210840L4 | Lenti ORF clone of Sarm1 (mGFP-tagged ORF) - Rat sterile alpha and TIR motif containing 1 (Sarm1), (10 ug) |
CNY 12,160.00 |
