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Mtmr6 (NM_001107268) Rat Untagged Clone
CAT＃: RN201213
Mtmr6 (untagged ORF) - Rat myotubularin related protein 6 (Mtmr6), (10 ug)
CNY 3,990.00
Product images
Specifications
| Product Data | |
| Type | Rat Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RN201213 representing NM_001107268
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCACATCCGGACAACCAAGGTTGAACAAGTAAAGTTACTTGACCGGTTTAGTACCAACAACAAGT CACTGACAGGAACACTGTATCTTACGGCCACACACCTATTATTTATTGATGCTCATCAAAAAGAAACCTG GATACTACATCACCATATTGCCTCCGTGGAGAAACTTGCTCTGACCACTTCTGGATGCCCACTCGTGATT CAGTGCAAGAACTTCAGGATTGTGCATTTCATTGTTCCCAGGGAAAGAGATTGCCATGATATTTATAACT CTCTACTGCAACTATCAAAACAAGCAAAATATGAAGATCTGTATGCATTCTCTTACAACCCCAAGCAAAA TGACACTGAGCGGCTGAACGGGTGGCAGCTCATTGACCTTGCTGCAGAGTACGAGAGGATGGGAGTGCCC AACGCAAACTGGCAACTGTCCGATGCCAACCGAGAGTACAAGGTCTGTGAGACTTATCCCAGAGAGCTGT ATGTTCCTCGGACAGCTAGCCGGCCAGTGATCGTCGGCAGTTCCAACTTCCGGAGCAAGGGCAGACTTCC GGTCCTGTCCTACTGCCAGCAGGGCACTGAGGCTGCCATTTGTCGATGCAGTCAGCCATTGTCAGGCTTC AGTGCCAGGTGCCTAGAGGATGAGCATTTGCTTCAAGCCATTAGTAAAGCCAACCCAGGAAACCGCTACA TGTATGTTGTGGATACCAGGCCCAAGCTCAATGCAATGGCTAACAGAGCAGCTGGAAAAGGTTATGAAAA TGAAGACAACTATTCTAATATTAGATTTCAGTTTGTTGGAATAGAAAATATTCATGTCATGAGATCCAGC CTTCAGAAATTACTGGAAGTGAATGGCAGCAAGGGGCTTTCTGTCAACGATTTCTACTCTGGTTTGGAGA GTTCAGGATGGCTTCGTCATATCAAGGCTGTTTTGGATGCTGCAATCTTCTTAGCCAAAGTAACTATCTC TTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001107268 |
| Insert Size | 984 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001107268.1, NP_001100738.1 |
| RefSeq Size | 3779 bp |
| RefSeq ORF | 984 bp |
| Locus ID | 305935 |
| Gene Summary | Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (PubMed:23188820). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RR201213 | Mtmr6 (Myc-DDK-tagged ORF) - Rat myotubularin related protein 6 (Mtmr6), (10 ug) |
CNY 3,990.00 |
|
| RR201213L3 | Lenti ORF clone of Mtmr6 (Myc-DDK-tagged ORF) - Rat myotubularin related protein 6 (Mtmr6), (10 ug) |
CNY 6,080.00 |
|
| RR201213L4 | Lenti ORF clone of Mtmr6 (mGFP-tagged ORF) - Rat myotubularin related protein 6 (Mtmr6), (10 ug) |
CNY 6,650.00 |
