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Metabotropic Glutamate Receptor 1 (GRM1) (NM_001278067) Human Tagged ORF Clone
CAT＃: RG239765
- TrueORF®
GRM1 (tGFP-tagged) - Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 6
ORF Plasmid: DDK
"NM_001278067" in other vectors (2)
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CNY 7,510.00
货期*
2周
规格
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经常一起买 (5)
Specifications
| Product Data | |
| Tag | TurboGFP |
| Synonyms | GPRC1A; MGLU1; MGLUR1; PPP1R85; SCA44; SCAR13 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG239765 representing NM_001278067.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGTCGGGCTCCTTTTGTTTTTTTTCCCAGCGATCTTTTTGGAGGTGTCCCTTCTCCCCAGAAGCCCC GGCAGGAAAGTGTTGCTGGCAGGAGCGTCGTCTCAGCGCTCGGTGGCCAGAATGGACGGAGATGTCATC ATTGGAGCCCTCTTCTCAGTCCATCACCAGCCTCCGGCCGAGAAAGTGCCCGAGAGGAAGTGTGGGGAG ATCAGGGAGCAGTATGGCATCCAGAGGGTGGAGGCCATGTTCCACACGTTGGATAAGATCAACGCGGAC CCGGTCCTCCTGCCCAACATCACCCTGGGCAGTGAGATCCGGGACTCCTGCTGGCACTCTTCCGTGGCT CTGGAACAGAGCATTGAGTTCATTAGGGACTCTCTGATTTCCATTCGAGATGAGAAGGATGGGATCAAC CGGTGTCTGCCTGACGGCCAGTCCCTCCCCCCAGGCAGGACTAAGAAGCCCATTGCGGGAGTGATCGGT CCCGGCTCCAGCTCTGTAGCCATTCAAGTGCAGAACCTGCTCCAGCTCTTCGACATCCCCCAGATCGCT TATTCAGCCACAAGCATCGACCTGAGTGACAAAACTTTGTACAAATACTTCCTGAGGGTTGTCCCTTCT GACACTTTGCAGGCAAGGGCCATGCTTGACATAGTCAAACGTTACAATTGGACCTATGTCTCTGCAGTC CACACGGAAGGGAATTATGGGGAGAGCGGAATGGACGCTTTCAAAGAGCTGGCTGCCCAGGAAGGCCTC TGTATCGCCCATTCTGACAAAATCTACAGCAACGCTGGGGAGAAGAGCTTTGACCGACTCTTGCGCAAA CTCCGAGAGAGGCTTCCCAAGGCTAGAGTGGTGGTCTGCTTCTGTGAAGGCATGACAGTGCGAGGACTC CTGAGCGCCATGCGGCGCCTTGGCGTCGTGGGCGAGTTCTCACTCATTGGAAGTGATGGATGGGCAGAC AGAGATGAAGTCATTGAAGGTTATGAGGTGGAAGCCAACGGGGGAATCACGATAAAGCTGCAGTCTCCA GAGGTCAGGTCATTTGATGATTATTTCCTGAAACTGAGGCTGGACACTAACACGAGGAATCCCTGGTTC CCTGAGTTCTGGCAACATCGGTTCCAGTGCCGCCTTCCAGGACACCTTCTGGAAAATCCCAACTTTAAA CGAATCTGCACAGGCAATGAAAGCTTAGAAGAAAACTATGTCCAGGACAGTAAGATGGGGTTTGTCATC AATGCCATCTATGCCATGGCACATGGGCTGCAGAACATGCACCATGCCCTCTGCCCTGGCCACGTGGGC CTCTGCGATGCCATGAAGCCCATCGACGGCAGCAAGCTGCTGGACTTCCTCATCAAGTCCTCATTCATT GGAGTATCTGGAGAGGAGGTGTGGTTTGATGAGAAAGGAGACGCTCCTGGAAGGTATGATATCATGAAT CTGCAGTACACTGAAGCTAATCGCTATGACTATGTGCACGTTGGAACCTGGCATGAAGGAGTGCTGAAC ATTGATGATTACAAAATCCAGATGAACAAGAGTGGAGTGGTGCGGTCTGTGTGCAGTGAGCCTTGCTTA AAGGGCCAGATTAAGGTTATACGGAAAGGAGAAGTGAGCTGCTGCTGGATTTGCACGGCCTGCAAAGAG AATGAATATGTGCAAGATGAGTTCACCTGCAAAGCTTGTGACTTGGGATGGTGGCCCAATGCAGATCTA ACAGGCTGTGAGCCCATTCCTGTGCGCTATCTTGAGTGGAGCAACATCGAATCCATTATAGCCATCGCC TTTTCATGCCTGGGAATCCTTGTTACCTTGTTTGTCACCCTAATCTTTGTACTGTACCGGGACACACCA GTGGTCAAATCCTCCAGTCGGGAGCTCTGCTACATCATCCTAGCTGGCATCTTCCTTGGTTATGTGTGC CCATTCACTCTCATTGCCAAACCTACTACCACCTCCTGCTACCTCCAGCGCCTCTTGGTTGGCCTCTCC TCTGCGATGTGCTACTCTGCTTTAGTGACTAAAACCAATCGTATTGCACGCATCCTGGCTGGCAGCAAG AAGAAGATCTGCACCCGGAAGCCCAGGTTCATGAGTGCCTGGGCTCAGGTGATCATTGCCTCAATTCTG ATTAGTGTGCAACTAACCCTGGTGGTAACCCTGATCATCATGGAACCCCCTATGCCCATTCTGTCCTAC CCAAGTATCAAGGAAGTCTACCTTATCTGCAATACCAGCAACCTGGGTGTGGTGGCCCCTTTGGGCTAC AATGGACTCCTCATCATGAGCTGTACCTACTATGCCTTCAAGACCCGCAACGTGCCCGCCAACTTCAAC GAGGCCAAATATATCGCGTTCACCATGTACACCACCTGTATCATCTGGCTAGCTTTTGTGCCCATTTAC TTTGGGAGCAACTACAAGATCATCACAACTTGCTTTGCAGTGAGTCTCAGTGTAACAGTGGCTCTGGGG TGCATGTTCACTCCCAAGATGTACATCATTATTGCCAAGCCTGAGAGGAATGTCCGCAGTGCCTTCACC ACCTCTGATGTTGTCCGCATGCATGTTGGCGATGGCAAGCTGCCCTGCCGCTCCAACACTTTCCTCAAC ATCTTCCGAAGAAAGAAGGCAGGGGCAGGGAATGCCAAGTGGAGGACAGGTGCCCAAGGGACAGCATAT GTGGCACCGCCTCTCTGTGCACGTGAAGACCAA ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG239765
Blue=ORF Red=Cloning site Green=Tag(s) MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGE IREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN RCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPS DTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRK LRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSP EVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVI NAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMN LQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKE NEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTP VVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSK KKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGY NGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALG CMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNAKWRTGAQGTAY VAPPLCAREDQ TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001278067 |
| ORF Size | 2724 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001278067.1, NP_001264996.1 |
| RefSeq Size | 6672 bp |
| RefSeq ORF | 2727 bp |
| Locus ID | 2911 |
| UniProt ID | Q13255 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Gap junction, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction |
| MW | 101.9 kDa |
| Gene Summary | This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] |
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