United States
Germany
Japan
United Kingdom
China
ITM2C (NM_001287241) Human Tagged ORF Clone
CAT＃: RG237044
- TrueORF®
ITM2C (tGFP-tagged) - Human integral membrane protein 2C (ITM2C), transcript variant 5
ORF Plasmid: DDK
"NM_001287241" in other vectors (2)
Need custom modification / cloning service?
Get a free quote
CNY 4,370.00
Product images
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | BRI3; BRICD2C; E25; E25C; ITM3 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG237044 representing NM_001287241.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGTGAAGATTAGCTTCCAGCCCGCCGTGGCTGGCATCAAGGGCGACAAGGCTGACAAGGCGTCGGCG TCGGCCCCTGCGCCGGCCTCGGCCACCGAGATCCTGCTGACGCCGGCTAGGGAGGAGCAGCCCCCACAA CATCGATCCAAGAGGGGGAGCTCAGTGGGCGGCGTGTGCTACCTGTCGATGGGCATGGTCGTGCTGCTC ATGGGCCTCGTGTTCGCCTCTGTCTACATCTACAGATACTTCTTTCTTGCACAGCTGGCCCGAGATAAC TTCTTCCGCTGTGGTGTGCTGTATGAGGACTCCCTGTCCTCCCAGGTCCGGACTCAGATGGAGCTGGAA GAGGATGTGAAAATCTACCTCGACGAGAACTACGAGCGCATCAACGTGCCTGTGCCCCAGTTTGGCGGC GGTGACCCTGCAGACATCATCCATGACTTCCAGCGGGGTCTGACTGCGTACCATGATATCTCCCTGGAC AAGTGCTATGTCATCGAACTCAACACCACCATTGTGCTGCCCCCTCGCAACTTCTGGGAGCTCCTCATG AACGTGAAGAGGGGGACCTACCTGCCGCAGACGTACATCATCCAGGAGGAGATGGTGGTCACGGAGCAT GTCAGTGACAAGGAGGCCCTGGGGTCCTTCATCTACCACCTGTGCAACGGGAAAGACACCTACCGGCTC CGGCGCCGGGCAACGCGGAGGCGGATCAACAAGCGTGGGGCCAAGAACTGCAATGCCATCCGCCACTTC GAGAACACCTTCGTGGTGGAGACGCTCATCTGCGGGGTGGTG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG237044
Blue=ORF Red=Cloning site Green=Tag(s) MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGSSVGGVCYLSMGMVVLL MGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGG GDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEH VSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001287241 |
| ORF Size | 801 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001287241.1, NP_001274170.1 |
| RefSeq Size | 2247 bp |
| RefSeq ORF | 804 bp |
| Locus ID | 81618 |
| UniProt ID | Q9NQX7 |
| Protein Families | Transmembrane |
| MW | 30.3 kDa |
| Gene Summary | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
