NRG3 (NM_001165973) Human Tagged ORF Clone
CAT#: RG228414
- TrueORF®
NRG3 (tGFP-tagged) - Human neuregulin 3 (NRG3), transcript variant 3
ORF Plasmid: DDK
"NM_001165973" in other vectors (4)
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CNY 4,850.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | HRG3; pro-NRG3 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RG228414 representing NM_001165973
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGTGTGGTATACCTCCAACCCTTGTATGCGTTGGGAGAGGAGGGGGACTACACACGATCAATATAA TCATCTGGTATTATTTTCCTTCTGCCTGGAGGACTTGCTTTAACATTTCAAGTAGTGTGGGTCTGCTGCT GACGAATTCATACAAATTTTATACGACGACATATTCCACAGAGCGATCCGAGCACTTCAAACCCTGCCGA GACAAGGACCTTGCATACTGTCTCAATGATGGCGAGTGCTTTGTGATCGAAACCCTGACCGGATCCCATA AACACTGTCGGTGCAAAGAAGGCTACCAAGGAGTCCGTTGTGATCAATTTCTGCCGAAAACTGATTCCAT CTTATCGGATCCAACAGACCACTTGGGGATTGAATTCATGGAGAGTGAAGAAGTTTATCAAAGGCAGGTG CTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTCTACTTCAAAA GCAAGAAACAAGCTAAACAAATCCAAGAGCAGCTGAAAGTGCCACAAAATGGTAAAAGCTACAGTCTCAA AGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAAGAGCCATGTCCAGCTGCAAAATTATTCAAAG GTGGAAAGGCATCCTGTGACTGCATTGGAGAAAATGATGGAGTCAAGTTTTGTCGGCCCCCAGTCATTCC CTGAGGTCCCTTCTCCTGACAGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAG CCCAGGGCAAAGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGG CTAGGTGGAATTGTGGGACCAGCATATCAGCAACTCGAAGAATCAAGGATCCCAGACCAGGATACGATAC CTTGCCAAGGGATAGAGGTCAGGAAGACTATATCCCACCTGCCTATACAGCTGTGGTGTGTTGAAAGACC CCTGGACTTAAAGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATCAATAAATATGCAACTGCCT TCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAGGACCTGGTGGGCTATTCATCCACAAGGG CCAGTTCTGTGCCCATCATCCCTTCAGTGGGTTTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGA AGTCAAAAGCATCAAATGGTGCAAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGC GATTGTCTTATAGCAGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCAGATCCGAATTC TGACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGCAAGCGAAAA CACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAATTTGTCTTAAGAAATGAA ATACAAAGAGACTCTGCATTGACCAAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >RG228414 representing NM_001165973
Red=Cloning site Green=Tags(s) MECGIPPTLVCVGRGGGLHTINIIIWYYFPSAWRTCFNISSSVGLLLTNSYKFYTTTYSTERSEHFKPCR DKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQV LSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSK VERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSR LGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLP SRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVS DCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNE IQRDSALTK TRTRPLE - GFP Tag - V |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_001165973 |
ORF Size | 1497 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001165973.1, NP_001159445.1 |
RefSeq Size | 3348 bp |
RefSeq ORF | 1500 bp |
Locus ID | 10718 |
UniProt ID | P56975 |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | ErbB signaling pathway |
Gene Summary | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC228414 | NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 3 |
CNY 3,656.00 |
|
RC228414L3 | Lenti ORF clone of Human neuregulin 3 (NRG3), transcript variant 3, Myc-DDK-tagged |
CNY 6,270.00 |
|
RC228414L4 | Lenti ORF clone of Human neuregulin 3 (NRG3), transcript variant 3, mGFP tagged |
CNY 6,270.00 |
|
SC327049 | NRG3 (untagged)-Human neuregulin 3 (NRG3) transcript variant 3 |
CNY 7,980.00 |