SLC39A14 (NM_001128431) Human Tagged ORF Clone
CAT#: RC225845
- TrueORF®
SLC39A14 (Myc-DDK-tagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1
ORF Plasmid: tGFP
"NM_001128431" in other vectors (6)
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CNY 5,488.00
Cited in 2 publications. |
CNY 300.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | cig19; HCIN; HMNDYT2; LZT-Hs4; NET34; ZIP14 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC225845 representing NM_001128431
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAAGCTGCTGCTGCTGCACCCGGCCTTCCAGAGCTGCCTCCTGCTGACCCTGCTTGGCTTATGGAGAA CCACCCCTGAGGCTCACGCTTCATCCCTGGGTGCACCAGCTATCAGCGCTGCCTCCTTCCTGCAGGATCT AATACATCGGTATGGCGAGGGTGACAGCCTCACTCTGCAGCAGCTGAAGGCCCTACTCAACCACCTGGAT GTGGGAGTGGGCCGGGGTAATGTCACCCAGCACGTGCAAGGACACAGGAACCTCTCCACGTGCTTTAGTT CTGGAGACCTCTTCACTGCCCACAATTTCAGCGAGCAGTCGCGGATTGGGAGCAGCGAGCTCCAGGAGTT CTGCCCCACCATCCTCCAGCAGCTGGATTCCCGGGCCTGCACCTCGGAGAACCAGGAAAACGAGGAGAAT GAGCAGACGGAGGAGGGGCGGCCAAGCGCTGTTGAAGTGTGGGGATACGGTCTCCTCTGTGTGACCGTCA TCTCCCTCTGCTCCCTCCTGGGGGCCAGCGTGGTGCCCTTCATGAAGAAGACCTTTTACAAGAGGCTGCT GCTCTACTTCATAGCTCTGGCGATTGGAACCCTCTACTCCAACGCCCTCTTCCAGCTCATCCCGGAGGCA TTTGGTTTCAACCCTCTGGAAGATTATTATGTCTCCAAGTCTGCAGTGGTGTTTGGGGGCTTTTATCTTT TCTTTTTCACAGAGAAGATCTTGAAGATTCTTCTTAAGCAGAAAAATGAGCATCATCATGGACACAGCCA TTATGCCTCTGAGTCGCTTCCCTCCAAGAAGGACCAGGAGGAGGGGGTGATGGAGAAGCTGCAGAACGGG GACCTGGACCACATGATTCCTCAGCACTGCAGCAGTGAGCTGGACGGCAAGGCGCCCATGGTGGACGAGA AGGTCATTGTGGGCTCGCTCTCTGTGCAGGACCTGCAGGCTTCCCAGAGTGCTTGCTACTGGCTGAAAGG TGTCCGCTACTCTGATATCGGCACTCTGGCCTGGATGATCACTCTGAGCGACGGCCTCCATAATTTCATC GATGGCCTGGCCATCGGTGCTTCCTTCACTGTGTCAGTTTTCCAAGGCATCAGCACCTCGGTGGCCATCC TCTGTGAGGAGTTCCCACATGAGCTAGGAGACTTTGTCATCCTGCTCAACGCTGGGATGAGCATCCAACA AGCTCTCTTCTTCAACTTCCTTTCTGCCTGCTGCTGCTACCTGGGTCTGGCCTTTGGCATCCTGGCCGGC AGCCACTTCTCTGCCAACTGGATTTTTGCGCTAGCTGGAGGAATGTTCTTGTATATTTCTCTGGCTGATA TGTTCCCTGAGATGAATGAGGTCTGTCAAGAGGATGAAAGGAAGGGCAGCATCTTGATTCCATTTATCAT CCAGAACCTGGGCCTCCTGACTGGATTCACCATCATGGTGGTCCTCACCATGTATTCAGGACAGATCCAG ATTGGG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC225845 representing NM_001128431
Red=Cloning site Green=Tags(s) MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQQLKALLNHLD VGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQENEEN EQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEA FGFNPLEDYYVSKSAVVFGGFYLFFFTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNG DLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFI DGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAG SHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQ IG TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_001128431 |
ORF Size | 1476 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001128431.4 |
RefSeq ORF | 1479 bp |
Locus ID | 23516 |
UniProt ID | Q15043 |
Protein Families | Transmembrane |
MW | 54 kDa |
Gene Summary | This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017] |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
---|
The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14
,Zhao, N;Zhang, AS;Wortham, AM;Jue, S;Knutson, MD;Enns, CA;,
Nutrients
,PubMed ID 29292794
[SLC39A14]
|
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia
,Tuschl, K;Meyer, E;Valdivia, LE;Zhao, N;Dadswell, C;Abdul-Sada, A;Hung, CY;Simpson, MA;Chong, WK;Jacques, TS;Woltjer, RL;Eaton, S;Gregory, A;Sanford, L;Kara, E;Houlden, H;Cuno, SM;Prokisch, H;Valletta, L;Tiranti, V;Younis, R;Maher, ER;Spencer, J;Straatman-Iwanowska, A;Gissen, P;Selim, LA;Pintos-Morell, G;Coroleu-Lletget, W;Mohammad, SS;Yoganathan, S;Dale, RC;Thomas, M;Rihel, J;Bodamer, OA;Enns, CA;Hayflick, SJ;Clayton, PT;Mills, PB;Kurian, MA;Wilson, SW;,
Nat Commun
,PubMed ID 27231142
[SLC39A14]
|
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC225845L1 | Lenti-ORF clone of SLC39A14 (Myc-DDK-tagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1 |
CNY 7,888.00 |
|
RC225845L2 | Lenti-ORF clone of SLC39A14 (mGFP-tagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1 |
CNY 5,890.00 |
|
RC225845L3 | Lenti-ORF clone of SLC39A14 (Myc-DDK-tagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1 |
CNY 7,888.00 |
|
RC225845L4 | Lenti-ORF clone of SLC39A14 (mGFP-tagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1 |
CNY 5,890.00 |
|
RG225845 | SLC39A14 (tGFP-tagged) - Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1 |
CNY 4,370.00 |
|
SC323103 | SLC39A14 (untagged)-Human solute carrier family 39 (zinc transporter), member 14 (SLC39A14), transcript variant 1 |
CNY 5,488.00 |
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