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ZCWCC1 (MORC2) (NM_014941) Human Tagged ORF Clone
CAT＃: RC200518
MORC2 (Myc-DDK-tagged)-Human MORC family CW-type zinc finger 2 (MORC2)
ORF Plasmid: tGFP
"NM_014941" in other vectors (7)
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CNY 7,104.00
| Cited in 7 publications. |
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | CMT2Z; DIGFAN; ZCW3; ZCWCC1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC200518 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCTTTGCTTTTTGGATGATGGAGCAGGAATGGATCCAAGTGATGCTGCCAGTGTGATCCAGTTTGGGA AGTCGGCCAAGCGAACACCTGAGTCTACTCAGATTGGGCAGTACGGGAATGGGTTAAAATCGGGCTCAAT GCGCATTGGGAAGGATTTTATCCTGTTCACCAAGAAGGAAGACACCATGACCTGCCTCTTCCTGTCTCGC ACGTTTCATGAGGAAGAAGGCATTGATGAAGTGATAGTCCCACTGCCCACCTGGAATGCTCGGACCCGGG AACCTGTCACAGACAATGTAGAGAAATTTGCCATTGAGACAGAACTCATCTATAAGTACTCTCCATTCCG CACTGAGGAGGAAGTGATGACCCAGTTTATGAAGATTCCTGGGGACAGCGGAACATTGGTGATCATCTTC AATCTCAAACTCATGGATAATGGAGAGCCAGAACTAGACATAATCTCAAATCCAAGAGATATCCAGATGG CAGAGACGTCCCCAGAGGGCACGAAGCCAGAGCGGCGCTCGTTCCGTGCCTATGCCGCTGTGCTCTATAT TGATCCCCGGATGAGGATCTTCATCCATGGGCACAAGGTGCAGACCAAGAGGCTCTCCTGCTGCCTGTAC AAGCCCAGGATGTACAAGTACACGTCAAGCCGTTTCAAGACCCGTGCGGAGCAGGAGGTGAAGAAAGCAG AGCACGTAGCAAGGATTGCTGAAGAGAAGGCGCGGGAGGCAGAGAGCAAAGCTCGGACATTAGAAGTACG CCTAGGTGGAGACCTCACGCGGGACTCCAGGGTGATGTTGCGACAGGTCCAGAACAGAGCCATCACTCTG CGCAGAGAAGCCGATGTCAAGAAGAGGATCAAGGAGGCCAAGCAGCGAGCACTTAAAGAACCTAAGGAAC TGAATTTTGTTTTTGGTGTCAACATTGAACACCGGGATCTGGATGGCATGTTCATCTACAACTGTAGCCG ACTGATCAAAATGTATGAGAAAGTGGGCCCACAGCTGGAAGGGGGCATGGCATGTGGCGGGGTTGTTGGG GTTGTTGATGTGCCCTACCTGGTCCTGGAGCCTACACACAACAAACAGGACTTTGCTGATGCCAAGGAGT ACCGGCACCTGCTCCGAGCAATGGGGGAGCACCTGGCGCAGTATTGGAAGGATATTGCCATCGCCCAGAG GGGAATCATCAAGTTCTGGGATGAGTTTGGCTACCTCTCTGCCAACTGGAACCAGCCCCCATCCAGTGAG CTGCGTTACAAACGCCGGAGAGCTATGGAAATCCCCACCACCATCCAGTGCGATTTGTGTCTGAAATGGA GAACCCTCCCCTTCCAGCTGAGTTCTGTGGAAAAAGATTACCCTGACACCTGGGTTTGCTCCATGAACCC TGATCCTGAACAGGACCGGTGTGAGGCTTCTGAACAAAAGCAGAAGGTTCCCCTGGGAACATTCAGAAAG GACATGAAGACGCAGGAAGAGAAGCAGAAACAACTGACAGAGAAAATTCGCCAGCAGCAGGAGAAGCTGG AGGCCCTTCAGAAAACCACACCCATCCGCTCCCAAGCAGACCTGAAGAAATTGCCCTTGGAAGTGACCAC CAGACCTTCCACTGAGGAACCTGTGCGTAGACCTCAGCGTCCTCGGTCGCCCCCTTTACCTGCTGTGATC AGGAACGCCCCCAGCAGACCCCCTTCTTTGCCAACTCCTAGACCAGCCAGCCAGCCCCGAAAGGCTCCTG TCATCAGCAGTACCCCAAAGCTCCCTGCTTTGGCAGCCCGGGAGGAGGCCAGCACATCTAGGCTGCTCCA GCCACCTGAGGCACCCCGAAAGCCTGCCAACACTCTCGTCAAGACTGCATCCCGACCTGCCCCTCTGGTG CAGCAACTGTCACCATCTTTACTGCCCAACTCCAAGAGCCCTCGGGAGGTTCCTTCTCCCAAAGTCATCA AGACTCCAGTGGTGAAGAAGACAGAGTCACCCATCAAACTCTCCCCGGCTACCCCTAGTCGGAAGCGGAG TGTCGCAGTTTCTGATGAGGAAGAAGTTGAGGAGGAAGCTGAGAGGAGGAAGGAGAGGTGCAAGCGGGGC AGATTTGTTGTGAAGGAGGAAAAGAAGGACTCGAATGAGCTCTCAGACAGTGCTGGGGAAGAGGACTCGG CTGACCTCAAGAGAGCTCAGAAAGATAAAGGGCTGCACGTGGAGGTGCGTGTGAACAGGGAGTGGTACAC GGGCCGTGTCACAGCCGTGGAGGTGGGCAAGCATGTGGTGCGGTGGAAGGTGAAGTTTGACTACGTGCCC ACAGACACGACACCAAGAGACCGCTGGGTGGAGAAAGGCAGTGAGGATGTGCGGCTGATGAAACCCCCTT CTCCGGAACATCAGAGCCTTGATACACAACAGGAGGGCGGGGAGGAGGAGGTGGGCCCTGTGGCCCAGCA GGCCATAGCTGTCGCAGAGCCCTCCACTTCCGAATGCCTCCGCATTGAGCCTGACACCACTGCCCTGAGC ACCAATCACGAGACCATCGACCTGCTTGTCCAGATCCTCCGGAATTGTTTACGGTACTTCCTGCCTCCAA GTTTCCCCATCTCCAAGAAGCAGCTGAGTGCTATGAATTCAGATGAGCTAATATCTTTTCCTCTGAAGGA GTACTTCAAGCAATATGAAGTAGGGCTCCAAAACCTGTGCAATTCCTACCAGAGCCGTGCTGACTCCCGG GCCAAGGCCTCCGAGGAAAGCCTGCGCACCTCCGAGAGGAAGCTCCGCGAGACGGAGGAGAAGCTGCAGA AGCTGAGGACCAACATCGTGGCACTCCTGCAAAAGGTGCAGGAGGACATAGACATCAACACAGATGATGA GCTGGACGCCTACATTGAGGACCTCATCACCAAGGGGGAC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC200518 protein sequence
Red=Cloning site Green=Tags(s) MLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSR TFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIF NLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLY KPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITL RREADVKKRIKEAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVG VVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSE LRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTFRK DMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPSTEEPVRRPQRPRSPPLPAVI RNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKTASRPAPLV QQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRG RFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVP TDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALS TNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSR AKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_014941 |
| ORF Size | 2910 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_014941.3 |
| RefSeq Size | 4467 bp |
| RefSeq ORF | 2913 bp |
| Locus ID | 22880 |
| UniProt ID | Q9Y6X9 |
| MW | 110.7 kDa |
| Gene Summary | This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |
Citations (7)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression
,null,
Cell Death and Differentiation
,PubMed ID 34974534
[ZCWCC1]
|
|
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer
,Liu, HY;Liu, YY;Yang, F;Zhang, L;Zhang, FL;Hu, X;Shao, ZM;Li, DQ;,
Nucleic Acids Res.
,PubMed ID 32112098
[ZCWCC1]
|
|
Dimerization of MORC2 through its C-terminal coiled-coil domain enhances chromatin dynamics and promotes DNA repair
,Xie, HY;Zhang, TM;Hu, SY;Shao, ZM;Li, DQ;,
Cell Commun. Signal
,PubMed ID 31796101
[ZCWCC1]
|
|
Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells
,null,
Autophagy
,PubMed ID 32401166
[ZCWCC1]
|
|
MORC2 regulates DNA damage response through a PARP1-dependent pathway
,Zhang, L;Li, D;,
Nucleic Acids Research
[ZCWCC1]
|
|
Cancer-associated MORC2 mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer
,Zhang, FL;Cao, JL;Xie, HY;Sun, R;Yang, LF;Shao, ZM;Li, DQ;,
Cancer Res.
,PubMed ID 30093560
[ZCWCC1]
|
|
Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1
,Liao, XH;Zhang, Y;Dong, WJ;Shao, ZM;Li, DQ;,
Oncotarget
,PubMed ID 29228664
[ZCWCC1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200518L1 | Lenti ORF clone of Human MORC family CW-type zinc finger 2 (MORC2), Myc-DDK-tagged |
CNY 9,504.00 |
|
| RC200518L2 | Lenti ORF clone of Human MORC family CW-type zinc finger 2 (MORC2), mGFP tagged |
CNY 10,170.00 |
|
| RC200518L3 | Lenti ORF clone of Human MORC family CW-type zinc finger 2 (MORC2), Myc-DDK-tagged |
CNY 10,170.00 |
|
| RC200518L4 | Lenti ORF clone of Human MORC family CW-type zinc finger 2 (MORC2), mGFP tagged |
CNY 10,170.00 |
|
| RG200518 | MORC2 (tGFP-tagged) - Human MORC family CW-type zinc finger 2 (MORC2) |
CNY 9,120.00 |
|
| SC114779 | MORC2 (untagged)-Human MORC family CW-type zinc finger 2 (MORC2) |
CNY 7,112.00 |
|
| SC320309 | MORC2 (untagged)-Human MORC family CW-type zinc finger 2 (MORC2) |
CNY 7,112.00 |
