Arhgef2 (NM_001198912) Mouse Tagged ORF Clone
CAT#: MR231432
- TrueORF®
Arhgef2 (myc-DDK-tagged) - Mouse rho/rac guanine nucleotide exchange factor (GEF) 2 (Arhgef2), transcript variant 3
"NM_001198912" in other vectors (1)
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CNY 9,600.00
CNY 300.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | AA408978; GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40; mKIAA0651; P40 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MR231432 representing NM_001198912
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAAGGAAGCTAAAGATGCCCGCTATACCAACGGCCACCTCTTCACCACCATCTCCGTCTCCGGCATGA CCATGTGCTATGCCTGTAACAAGAGCATCACAGCCAAGGAAGCCCTCATTTGTCCTACATGTAACGTGAC CATCCACAACCGCTGTAAAGACACCCTGGCCAACTGTACCAAGGTCAAGCAGAAGCAACAGAAAGCTGCA CTGCTGAGGAACAACACTGCTTTGCAGTCTGTCTCCCTTCGAAGTAAGACGACCACCAGAGAGCGGCCAA CGTCTGCCATTTACCCTTCCGACAGCTTCCGGCAGTCCCTCCTGGGTTCTCGGCGGGGCCTCTCCTCCTT ATCTTTGGCCAAAAGTGTTTCCACTACCAACATTGCTGGACATTTCAATGATGAGTCTCCTCTGGGGCTG CGTCAGATCCTCTCCCAGTCCACAGACTCCCTCAACATGCGGAACCGAACCCTGTCCGTGGAATCCCTTA TTGATGAAGGTGTAGAAGTGTTCTACAATGAGCTGATGAGCGACTTTGAGATGGATGAGAAGGACTTTGA GGCGGATTCTTGGAGCCTTGCCGTGGACAGCAGCTTCCTGCAGCAGCACAAAAAGGAAGTGATGAAGAAG CAAGATGTCATCTATGAGCTGATCCAGACAGAGCTGCACCACGTGAGAACCTTGAAGATTATGACCCGCC TCTTTCGCACTGGGATGCTGGAAGAGTTGCAGATGGAGCCAGAAGTGGTCCAGGGCCTGTTCCCCTGCGT GGATGAACTCAGTGACATTCACACACGTTTCCTTAATCAGCTTCTGGAACGGCGGCGCCAGGCTCTATGT CCAGGCAGCACCCGGAACTTTGTCATCCATCGTTTGGGTGACTTGCTCATCAGTCAGTTCTCAGGTTCCA ATGCTGAGCAGATGCGCAAGACCTACTCAGAGTTCTGCAGCCGCCACACCAAGGCCTTAAAGCTCTATAA GGAGCTGTATGCTCGAGACAAACGCTTCCAACAGTTCATCCGGAAAATGACCCGCTCAGCTGTGTTGAAG CGGCATGGAGTTCAGGAATGCATTCTCCTGGTGACTCAGCGGATCACCAAATACCCTGTGCTCATCAACA GAATCCTGCAGAATTCCCACGGGGTTGAAGAAGAGTACCAAGACTTGGCGTCAGCCCTAGGACTAGTGAA GGAGTTGTTGTCCAATGTGGACCAGGATGTGCACGAGCTGGAGAAAGAGGCCCGCCTGCAGGAGATTTAC AACCGAATGGATCCCCGGGCTCAGACCCCCGTACCTGGCAAGGGCCCCTTCGGCCGAGATGAACTTTTAC GGAGAAAACTTATCCATGAAGGCTGCCTGCTCTGGAAGACAGCCACAGGCCGCTTCAAAGATGTCCTGTT GCTGCTGATGACAGATGTGCTCGTGTTTCTCCAGGAAAAGGACCAGAAATACATTTTCACGTCTCTGGAC AAGCCCTCAGTGGTGTCCTTGCAGAACCTCATCGTAAGAGACATAGCCAACCAGGCGAAAGGGATGTTTC TGATTAGTTCTGGACCGCCTGAGATGTATGAGGTGCATGCAGCGTCCCGAGACGACCGGACTACCTGGAT CCGTGTCATCCAGCAGAGTGTGCGCCTGTGCCCGTCCAGGGAGGACTTTCCTCTGATCGAGACAGAGGAT AAGGCGTATCTCCGGAGGATCAAGACGAAACTGCAGCAGAAAAACCAGGCGCTAGTGGAGCTGCTACAGA AGAATGTTGAGCTGTTTGCCGAGATGGTCCACTTCCAGGCCTTAAAGGCTGGCTTCGTTGGAATGCCCCC ACCCGCCCTGCCCAGGGGCCTTTTCCGTCTTGAGTCCTTTGAGTCCCTCCGAGGCGAGCGCCTGCTAAAG GATGCCCTCCGTGAAGTGGAAGGCCTGAAAGACCTGCTGTTGGGCCCATGTGTGGACCTGCCTATGACAT CCCGAGAACCAGCCTTACCCTTGGACTCTGACAGCGGTAGCTGTCCTGGGGTCACTGCCAATGGAGAGGC CAGAACCTTCAATGGCTCCATTGAACTCTGTAGAGCAGACTCGGATTCCAGCCAGAAGGATCGGAATGGA AATCAGTTGAGATCACCACAGGAGGAGGTGTTACAGCCATTGATCAATCTTTATGGACTTCTACATGGCC TGCAGGCTGTTGTGGTCCAGCAGGAAAGACTGATGGAAGCCCTGTTCCCTGAGGGCCCTGAACGGTGGGA AAAGCTATCCCGAGCCAACTCTCGGGATGGTGAAGCTGGCCGGGCTGCGGTTGCTTCTGTAACTCCTGAG AAGCAGGCCACGGAGCTGGCACTACTGCAGAGGCAACACACCCTGTTGCAGGAAGAGCTGCGGCGCTGCC AGCGGCTCGGGGAAGAGCGGGCAACTGAAGCTGGCAGCCTGGAGGCCAGGCTCCGAGAGAGCGAGCAAGC CCGGGCCCTGCTGGAGCGGGAGGCTGAAGAGATCCGCCGGCAGCTTGCAGCCTTGGGCCAAAACGAGCCA CTCCCGGCAGAAGCGCCCTGGGCTCGCAGGCCTCTGGACCCACGGCGCCGCAGCCTTCCAGCGGGCGACG CTTTATACTTGAGCTTCAATCCCCCCCAGCCCAGTCGAGGCCATGACCGCCTGGATTTGCCTGTGACTGT TCGTTCCCTCCACCGACCCTTTGATGACCGAGAGGCGCAAGAACTTGGTAGCCCCGAGGATCGACTACAG GACAGCAGTGACCCTGATACTGGTAGTGAGGAGGAAGTCAGTAGCCGCCTGTCTCCACCTCACAGTCCTC GAGACTTCACCCGAATGCAGGACATTCCTGAAGAGACAGAAAGCCGAGATGGGGAGCCCACAGCTTCAGA GAGC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR231432 representing NM_001198912
Red=Cloning site Green=Tags(s) MKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAA LLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFNDESPLGL RQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKK QDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLNQLLERRRQALC PGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLK RHGVQECILLVTQRITKYPVLINRILQNSHGVEEEYQDLASALGLVKELLSNVDQDVHELEKEARLQEIY NRMDPRAQTPVPGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLD KPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETED KAYLRRIKTKLQQKNQALVELLQKNVELFAEMVHFQALKAGFVGMPPPALPRGLFRLESFESLRGERLLK DALREVEGLKDLLLGPCVDLPMTSREPALPLDSDSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNG NQLRSPQEEVLQPLINLYGLLHGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPE KQATELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEP LPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQ DSSDPDTGSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTASES TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_001198912 |
ORF Size | 2874 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001198912.2 |
RefSeq Size | 4290 bp |
RefSeq ORF | 2877 bp |
Locus ID | 16800 |
UniProt ID | Q60875 |
MW | 109.2 kDa |
Gene Summary | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC229221 | Arhgef2 (untagged) - Mouse rho/rac guanine nucleotide exchange factor (GEF) 2 (Arhgef2), transcript variant 3 |
CNY 9,220.00 |
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