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Mapk8ip3 (NM_001163451) Mouse Tagged ORF Clone
CAT＃: MR223086
- TrueORF®
Mapk8ip3 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6
ORF Plasmid: tGFP
"NM_001163451" in other vectors (4)
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CNY 13,020.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MR223086 representing NM_001163451
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATGGAGATCCAGATGGACGAGGGAGGAGGAGTGGTGGTGTACCAAGACGACTACTGCTCGGGCTCGG TCATGTCGGAGCGTGTGTCGGGCCTGGCGGGCTCCATCTACCGCGAGTTCGAGCGCCTCATTCACTGCTA TGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTGAACGTGCTGGAGAACCTTGACTCGGTGCTG AGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTCCTACGCGAGGACAACGAGCAGCTGCTCACGCAAT ACGAGCGCGAGAAGGCGCTGCGCAAACAGGCCGAGGAGAAATTCATCGAATTTGAAGATGCCTTGGAACA AGAGAAGAAAGAACTCCAGATCCAGGTAGAACATTATGAGTTTCAGACACGCCAGCTGGAGCTAAAGGCC AAAAACTATGCAGATCAGATTTCCCGACTGGAGGAACGAGAATCGGAGATGAAGAAGGAATACAATGCCC TGCACCAGCGGCACACAGAGATGATCCAGACCTATGTGGAACACATTGAAAGATCCAAGATGCAGCAAGT TGGGGGTAGCGGCCAAACAGAAAGCAGCCTGCCCGGGCGGAGGAAGGAGCGTCCCACCTCTCTGAATGTC TTCCCCCTGGCTGATGGCATGTGTCCAAATGATGAGATGTCTGAGTCAGGCCAGTCCTCAGCAGCTGCAA CACCCAGTACCACAGGTACCAAGTCCAACACACCCACGTCCTCCGTGCCCTCAGCAGCAGTCACGCCACT CAACGAGAGCCTACAGCCCCTGGGGGACTATGTCAGTGTCACAAAGAACAACAAGCAGGCCCGAGAGAAG CGCAATAGCCGTAACATGGAGGTCCAGGTCACCCAAGAGATGCGGAACGTCAGTATCGGCATGGGCAGCA GTGACGAGTGGTCCGATGTTCAGGACATTATCGACTCCACCCCAGAGCTGGATGTGTGTCCTGAAACCCG TCTGGAGCGCACAGGAAGCAGCCCAACCCAGGGAATTGTAAACAAAGCTTTTGGAATCAACACTGACTCC TTGTATCACGAACTCTCCACGGCGGGATCTGAGGTCATCGGGGATGTGGACGAGGGAGCTGATCTCCTAG GGGAGTTTTCAGTGCGCGATGATTTTTTTGGAATGGGCAAAGAAGTGGGGAACCTGCTGCTGGAGAACTC ACAGCTTCTAGAGACAAAAAATGCTTTAAATGTAGTGAAGAATGACCTCATTGCTAAGGTTGACCAACTG TCAGGAGAACAGGAGGTCCTGAAGGGTGAGCTGGAAGCAGCCAAGCAAGCCAAAGTCAAGCTGGAGAACC GAATCAAAGAGCTTGAAGAAGAACTGAAGAGAGTCAAGTCAGAGGCAGTAACTGCCCGCCGTGAGCCCAG AGAAGAGGTGGAGGATGTAAGCAGCTATCTCTGTACAGAATTGGACAAAATCCCCATGGCCCAGCGCCGA CGCTTCACACGGGTGGAGATGGCCCGAGTGCTCATGGAACGCAACCAGTACAAGGAACGCCTCATGGAGC TGCAGGAGGCTGTGAGGTGGACTGAAATGATCAGAGCATCAAGGGAACACCCATCTGTCCAGGAGAAGAA GAAGTCCACCATCTGGCAGTTCTTTAGTCGCCTCTTCAGCTCCTCATCTAGCCCCCCTCCGGCCAAACGA TCCTACCCATCTGTGAACATTCACTACAAGTCACCCACTGCAGCTGGCTTTAGCCAGCGTCGCAGCCATG CTTTGTGCCAGATCTCAGCCGGCAGCAGGCCCCTGGAGTTCTTCCCTGATGATGACTGCACCTCTTCTGC CCGGCGGGAGCAGAAGCGGGAGCAGTACCGCCAGGTTCGTGAACACGTGCGCAATGATGACGGGAGGCTG CAGGCCTGTGGGTGGAGCCTGCCTGCCAAGTACAAGCAGCTGAGCCCCAATGGAGGCCAGGAAGACACCC GGATGAAAAATGTGCCTGTCCCTGTGTACTGCCGCCCTCTGGTGGAGAAGGACCCTTCGACAAAGCTGTG GTGTGCTGCTGGTGTCAACCTGAGTGGGTGGAAGCCACATGAAGAGGACTCTAGCAATGGACCCAAGCCT GTACCAGGTCGAGACCCTCTGACCTGTGACCGGGAAGGAGAAGGCGAACCCAAGAGCACACACCCATCAC CTGAGAAGAAGAAGGCAAAGGAAACCCCTGAGGCAGATGCTACCTCCAGTCGGGTATGGATCCTCACCAG CACCCTGACAACCAGCAAGGTGGTGATCATTGATGCCAACCAGCCAGGCACAATTGTGGATCAGTTCACA GTCTGCAATGCCCACGTCCTGTGTATCTCCAGCATTCCTGCGGCCAGTGACAGTGACTATCCCCCTGGGG AGATGTTCCTAGACAGTGATGTGAACCCTGAAGATTCAGGTGCTGATGGTGTGCTGGCTGGCATCACCCT GGTGGGGTGTGCTACCCGCTGCAATGTTCCACGTAGCAACTGTTCCTCACGAGGAGACACCCCAGTACTG GACAAGGGGCAGGGGGATGTGGCGACCACTGCCAATGGGAAGGTCAACCCGTCCCAATCCACAGAAGAAG CCACAGAAGCCACGGAGGTGCCAGACCCTGGTCCCAGCGAGTCAGAAGCAACGACAGTCCGGCCCGGGCC TCTCACAGAGCATGTCTTTACTGACCCAGCACCCACCCCATCCTCCAGCACCCAGCCTGCCAGTGAGAAT GGGTCAGAGTCCAATGGCACCATTGTACAGCCTCAGGTGGAGCCCAGTGGGGAACTCTCAACAACAACCA GTAGCGCTGCACCCACTATGTGGCTAGGAGCCCAGAATGGCTGGCTCTATGTGCATTCAGCGGTAGCCAA CTGGAAGAAGTGTCTGCACTCCATCAAGCTAAAAGACTCTGTGCTGAGCCTGGTGCATGTCAAAGGCCGA GTGCTGGTAGCTCTTGCAGATGGGACCCTGGCTATCTTCCATCGTGGAGAGGATGGCCAGTGGGACCTGA GCAACTACCACCTAATGGACCTGGGCCACCCACACCACTCCATCCGCTGCATGGCTGTTGTGAATGACCG AGTTTGGTGTGGCTACAAGAACAAGGTGCATGTTATCCAGCCCAAGACAATGCAGATTGAGAAATCATTT GATGCCCACCCAAGGCGGGAAAGCCAGGTACGTCAGCTGGCCTGGATCGGTGATGGAGTGTGGGTCTCTA TTCGCTTGGATTCTACCCTTCGGCTCTACCATGCTCACACCCACCAGCACCTGCAGGATGTGGACATTGA GCCCTATGTTAGCAAGATGCTAGGAACCGGCAAGCTGGGCTTCTCCTTCGTGCGCATCACAGCCTTACTC ATTGCAGGCAACCGTCTGTGGGTGGGCACTGGCAATGGGGTTGTCATCTCCATCCCCTTGACTGAGACTG TGGTCCTGCATCGAGGCCAGCTCCTAGGGCTCCGAGCCAACAAGACATCCCCAACATCTGGGGAGGGGAC CCGCCCAGGGGGCATCATCCATGTGTATGGGGACGACAGCAGTGACAAGGCCGCCAGTAGTTTCATCCCC TACTGCTCCATGGCACAGGCTCAGCTTTGCTTCCATGGGCACCGTGATGCTGTCAAATTCTTTGTCTCTG TGCCAGGAAATGTGCTGGCCACTCTCAATGGCAGTGTGCTAGACAGCCCATCAGAGGGCCCTGGGCCTGC TGCACCCGCTGCAGATGCTGAGGGCCAGAAGTTGAAGAATGCACTGGTGCTGAGTGGTGGTGAAGGTTAC ATTGACTTCCGTATCGGAGACGGAGAGGATGATGAAACTGAGGAATGTGCCGGGGACGTGAACCAGACAA AGCCCTCGTTGTCCAAGGCTGAGCGCAGCCACATCATCGTGTGGCAGGTGTCCTACACCCCTGAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR223086 representing NM_001163451
Red=Cloning site Green=Tags(s) MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVL SENQEHEVELELLREDNEQLLTQYEREKALRKQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKA KNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGSGQTESSLPGRRKERPTSLNV FPLADGMCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYVSVTKNNKQAREK RNSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPETRLERTGSSPTQGIVNKAFGINTDS LYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQL SGEQEVLKGELEAAKQAKVKLENRIKELEEELKRVKSEAVTARREPREEVEDVSSYLCTELDKIPMAQRR RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKR SYPSVNIHYKSPTAAGFSQRRSHALCQISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGRL QACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPSTKLWCAAGVNLSGWKPHEEDSSNGPKP VPGRDPLTCDREGEGEPKSTHPSPEKKKAKETPEADATSSRVWILTSTLTTSKVVIIDANQPGTIVDQFT VCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVL DKGQGDVATTANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTPSSSTQPASEN GSESNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGR VLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCGYKNKVHVIQPKTMQIEKSF DAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALL IAGNRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIP YCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKLKNALVLSGGEGY IDFRIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQVSYTPE TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001163451 |
| ORF Size | 3915 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001163451.1, NP_001156923.1 |
| RefSeq Size | 5483 bp |
| RefSeq ORF | 3918 bp |
| Locus ID | 30957 |
| UniProt ID | Q9ESN9 |
| MW | 144.6 kDa |
| Gene Summary | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553).[UniProtKB/Swiss-Prot Function] |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC224198 | Mapk8ip3 (untagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6, (10ug) |
CNY 16,820.00 |
|
| MG223086 | Mapk8ip3 (tGFP-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3) transcript variant 6, (10ug) |
CNY 14,350.00 |
|
| MR223086L3 | Lenti ORF clone of Mapk8ip3 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6 |
CNY 14,920.00 |
|
| MR223086L4 | Lenti ORF clone of Mapk8ip3 (mGFP-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6 |
CNY 14,920.00 |
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