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Taok1 (NM_144825) Mouse Tagged ORF Clone
CAT＃: MR218174
- TrueORF®
Taok1 (Myc-DDK-tagged) - Mouse TAO kinase 1 (Taok1)
ORF Plasmid: tGFP
"NM_144825" in other vectors (4)
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CNY 6,968.00
| Cited in 1 publication. |
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | 2810468K05Rik; AU020252; D130018F14Rik; Map3k16; Markk; mKIAA1361; Psk2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MR218174 representing NM_144825
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCCATCAACTAACAGAGCAGGCAGTCTAAAGGACCCTGAAATTGCAGAGCTCTTCTTCAAAGAAGATC CGGAAAAGCTCTTCACAGATCTCAGAGAAATCGGCCATGGGAGCTTTGGAGCAGTATATTTTGCACGAGA TGTGCGTACTAATGAAGTGGTGGCCATCAAGAAAATGTCTTATAGTGGAAAGCAGTCTACTGAGAAATGG CAGGATATTATTAAGGAAGTCAAGTTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCT GCTATTTACGTGAACACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCAGATTTATTAGA AGTTCATAAAAAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTCCAGGGACTAGCT TATTTACATTCTCATACCATGATCCATAGAGATATCAAAGCAGGAAATATCCTTCTGACAGAACCAGGCC AAGTGAAACTTGCTGACTTTGGATCTGCTTCCATGGCTTCCCCTGCCAATTCTTTTGTGGGAACACCATA TTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGACAGTATGATGGCAAAGTTGATGTATGGTCT CTTGGAATAACGTGTATTGAATTAGCCGAGAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCT TATATCACATAGCCCAAAATGAATCCCCTACACTACAATCTAATGAATGGTCTGATTATTTTCGAAACTT TGTAGATTCTTGCCTCCAGAAAATCCCTCAAGATCGCCCTACATCAGAGGAACTTTTAAAGCACATGTTT GTTCTTCGAGAGCGCCCTGAAACAGTGTTAATAGATCTTATTCAAAGGACAAAGGATGCAGTAAGAGAGC TGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCACATAATGGGCCAGCGGTAGA AGCACAGGAAGAAGAGGAGGAGCAAGATCATGGTGTTGGCCGAACAGGAACAGTGAATAGTGTTGGAAGC AATCAGTCTATCCCTAGTATGTCTATCAGTGCCAGCAGTCAAAGCAGCAGTGTTAATAGTCTTCCAGATG CATCAGATGACAAGAGTGAGCTAGACATGATGGAGGGAGACCATACAGTGATGTCTAACAGTTCTGTCAT CCACTTAAAACCTGAGGAGGAAAATTACCAGGAAGAAGGAGATCCTAGAACAAGAGCATCAGACCCACAG TCTCCCCCTCAGGTGTCTCGTCACAAGTCACATTATCGTAATAGAGAACACTTTGCAACCATACGAACAG CATCACTGGTTACAAGACAGATGCAAGAACATGAGCAGGACTCTGAACTTAGAGAACAGATGTCTGGTTA TAAGCGGATGAGGCGACAGCATCAAAAGCAGCTGATGACGCTGGAAAATAAACTGAAGGCAGAGATGGAC GAACATCGGCTCAGATTAGACAAAGATCTTGAAACTCAGCGTAACAATTTCGCTGCAGAAATGGAGAAAC TTATTAAGAAACACCAAGCTGCTATGGAAAAAGAGGCTAAAGTGATGGCCAATGAGGAGAAAAAATTCCA GCAACACATTCAGGCTCAACAGAAAAAAGAACTGAATAGCTTTTTGGAGTCTCAAAAAAGAGAATATAAA CTTCGCAAAGAGCAGCTTAAGGAGGAGCTGAATGAAAACCAGAGCACACCTAAAAAAGAAAAGCAGGAAT GGCTTTCAAAGCAGAAGGAGAATATACAGCATTTTCAGGCAGAAGAAGAAGCTAATCTTCTTCGACGTCA AAGGCAGTATCTAGAGCTAGAATGTCGTCGCTTCAAAAGAAGAATGTTACTTGGGCGACATAACTTGGAA CAGGACCTTGTCAGGGAGGAGTTAAACAAAAGGCAGACTCAAAAGGACTTGGAACATGCAATGCTATTGC GACAGCATGAATCAATGCAAGAACTGGAGTTTCGCCATCTCAACACTATTCAGAAGATGCGCTGTGAGTT GATCAGACTGCAGCATCAAACTGAGCTCACTAACCAGCTAGAGTACAATAAGAGAAGGGAACGGGAACTG AGGCGAAAACATGTCATGGAAGTTCGACAACAACCTAAGAGTCTGAAGTCTAAAGAACTCCAAATAAAAA AGCAGTTTCAGGATACCTGCAAAATTCAAACCAGACAGTACAAAGCATTAAGGAATCACCTACTGGAGAC TACACCAAAGAGTGAGCACAAAGCTGTTTTGAAAAGACTCAAGGAGGAACAGACTCGAAAGTTAGCCATC TTGGCTGAGCAGTATGATCATAGCATTAATGAAATGCTCTCCACACAAGCTCTGCGTTTGGATGAAGCAC AGGAAGCAGAATGCCAGGTTCTGAAGATGCAGCTGCAGCAGGAACTGGAGCTGCTGAATGCTTATCAGAG CAAAATAAAGATGCAAGCTGAGGCCCAACATGATCGAGAGCTTCGAGAGCTGGAACAGAGGGTCTCCCTT CGCAGAGCGCTCTTAGAACAAAAGATTGAAGAAGAGATGTTGGCTTTGCAGAATGAACGCACAGAACGAA TACGTAGCCTGCTCGAGCGTCAAGCCAGAGAAATTGAAGCATTTGACTCTGAAAGCATGAGATTAGGTTT TAGTAACATGGTCCTTTCTAATCTCTCCCCTGAGGCATTCAGCCACAGCTACCCAGGAGCTTCTAGTTGG TCTCACAATCCTACTGGGGGTCCAGGACCTCACTGGGGTCATCCCATGGGTGGCACACCACAAGCTTGGG GTCATCCGATGCAAGGTGGACCCCAACCATGGGGTCATCCCTCAGGGCCAATGCAAGGGGTACCTCGAGG TAGCAGTATGGGAGTCCGCAATAGCCCCCAGGCTTTGAGGCGGACAGCTTCTGGGGGACGGACGGAACAG GGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTCTTACACA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR218174 representing NM_144825
Red=Cloning site Green=Tags(s) MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKW QDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLA YLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWS LGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMF VLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGS NQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASDPQ SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMD EHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYK LRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLE QDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRREREL RRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAI LAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSW SHNPTGGPGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQ GMSRSTSVTSQISNGSHMSYT TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_144825 |
| ORF Size | 3003 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_144825.3 |
| RefSeq Size | 12411 bp |
| RefSeq ORF | 3006 bp |
| Locus ID | 216965 |
| UniProt ID | Q5F2E8 |
| MW | 116.5 kDa |
| Gene Summary | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis
,null,
Journal of Innate Immunity
,PubMed ID 36649698
[Taok1]
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Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC223157 | Taok1 (untagged) - Mouse TAO kinase 1 (Taok1), (10ug) |
CNY 12,920.00 |
|
| MG218174 | Taok1 (tGFP-tagged) - Mouse TAO kinase 1 (Taok1), (10ug) |
CNY 9,220.00 |
|
| MR218174L3 | Lenti ORF clone of Taok1 (Myc-DDK-tagged) - Mouse TAO kinase 1 (Taok1) |
CNY 10,260.00 |
|
| MR218174L4 | Lenti ORF clone of Taok1 (mGFP-tagged) - Mouse TAO kinase 1 (Taok1) |
CNY 10,260.00 |
