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Foxp1 (BC064764) Mouse Tagged ORF Clone
CAT＃: MR209941
- TrueORF®
Foxp1 (Myc-DDK-tagged) - Mouse forkhead box P1 (cDNA clone MGC:76591 IMAGE:30430449)
ORF Plasmid: tGFP
"BC064764" in other vectors (4)
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CNY 4,928.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | 3110052D19Rik; 4932443N09Rik; AI461938; AW494214 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MR209941 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATGCAAGAATCTGGGTCTGAGACAAAAAGTAACGGATCAGCCATCCAGAACGGGTCCAGCGGTGGCA ACCACTTACTAGAGTGCGGGGCACTTCGTGACACTCGGTCCAACGGAGAGGCACCAGCGGTGGACCTGGG GGCAGCCGACCTTGCCCACGTCCAGCAGCAGCAACAGCAGCAGCAACAACAGCAGCAGCAGCAACAGCAG CAGCAGCAGCAGCAAGTTAGTGGATTAAAGTCTCCCAAGAGGAATGACAAGCAACCAGCTCTTCAGGTTC CCGTGTCAGTGGCTATGATGACACCTCAGGTTATCACTCCTCAACAAATGCAGCAGATCCTCCAGCAGCA GGTGCTGAGCCCCCAGCAGCTCCAGGTTCTCCTCCAGCAGCAGCAGGCCCTCATGCTTCAACAGCAGCTT CAAGAATTTTATAAAAAACAACAGGAACAGTTGCAGCTTCAACTTCTCCAACAGCAACATGCTGGAAAAC AGCCGAAAGAGCAGCAGGTGGCTACCCAGCAGTTGGCTTTCCAGCAGCAGCTTCTCCAGATGCAGCAGCT GCAGCAGCAGCACCTCTTGTCTCTCCAGCGCCAAGGCCTCCTAACAATTCAGCCGGGGCAGCCTGCCCTT CCCCTCCAACCCCTCGCTCAAGGCATGATTCCAACGGAACTGCAGCAGCTCTGGAAAGAAGTGACAAGTG CCCACACTGCAGAGGAAACCACAAGCAGCAACCACAGCAGCCTAGACCTGACCAGCACATGTGTCTCGTC CTCGGCACCTTCCAAGTCCTCCCTAATCATGAACCCGCATGCCTCTACCAATGGACAGCTCTCGGTCCAC ACTCCCAAAAGGGAAAGCTTGTCCCACGAGGAGCACCCCCACAGCCACCCTCTCTATGGACATGGCGTAT GCAAGTGGCCAGGCTGTGAGGCGGTTTGTGACGACTTCCCAGCCTTTCTAAAACATCTCAACAGTGAGCA TGCGCTGGACGATAGAAGCACAGCTCAATGTAGAGTACAAATGCAGGTTGTACAGCAGTTAGAGCTACAG CTTGCAAAAGACAAAGAGCGCCTGCAAGCCATGATGACCCACCTGCATGTGAAGTCTACAGAACCCAAAG CTGCCCCTCAGCCCCTGAATCTGGTATCAAGTGTCACCCTCTCCAAGTCTGCCTCAGAGGCTTCTCCACA GAGCTTACCTCATACTCCAACAACCCCCACCGCCCCCCTGACTCCTGTCACCCAAGGCCCCTCCGTCATC ACCACCACCAGCATGCACACGGTGGGACCTATCCGCAGGCGGTACTCAGACAAATACAACGTGCCCATTT CTTCAGCAGATATTGCGCAGAACCAAGAATTTTATAAGAACGCGGAAGTTAGACCACCATTTACATATGC ATCTTTAATCAGGCAGGCCATTCTCGAATCTCCAGAAAAGCAGCTAACACTAAACGAAATCTATAACTGG TTCACACGAATGTTTGCTTACTTCCGACGCAATGCAGCCACGTGGAAGAATGCAGTGCGTCATAATCTTA GTCTCCACAAGTGTTTTGTGCGAGTAGAGAACGTTAAAGGGGCAGTATGGACAGTGGATGAAGTAGAGTT CCAAAAACGGAGGCCACAAAAGATCAGTGGTAACCCTTCCCTTATTAAAAACATGCAGAGCAGCCACGCC TACTGCACACCTCTCAATGCAGCTTTACAGGCTTCCATGGCTGAGAATAGTATACCTCTGTACACTACCG CTTCCATGGGAAATCCCACTCTGGGCAGCCTGGCCAGTGCCATCCGGGAGGAGCTGAACGGGGCCATGGA GCACACCAACAGCAACGAGAGTGACAGCAGTCCAGGCAGATCCCCTATGCAAGCTGTGCACCCCATACAC GTCAAAGAAGAACCCCTCGACCCCGAGGAAGCTGAAGGCCCTCTGTCCTTAGTGACAACAGCCAACCACA GTCCAGATTTTGACCATGACAGAGATTACGAAGACGAACCAGTAAATGAGGACATGGAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR209941 protein sequence
Red=Cloning site Green=Tags(s) MMQESGSETKSNGSAIQNGSSGGNHLLECGALRDTRSNGEAPAVDLGAADLAHVQQQQQQQQQQQQQQQQ QQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQL QEFYKKQQEQLQLQLLQQQHAGKQPKEQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPAL PLQPLAQGMIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMNPHASTNGQLSVH TPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQ LAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVI TTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNW FTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHA YCTPLNAALQASMAENSIPLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIH VKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | BC064764 |
| ORF Size | 2019 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC064764, AAH64764 |
| RefSeq Size | 2348 bp |
| RefSeq ORF | 2021 bp |
| Locus ID | 108655 |
| MW | 74.9 kDa |
| Gene Summary | Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (PubMed:11358962, PubMed:14701752). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2 (PubMed:11358962, PubMed:22675208). Essential transcriptional regulator of B-cell development (PubMed:16819554). Involved in regulation of cardiac muscle cell proliferation (PubMed:20713518). Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins (PubMed:18667151, PubMed:18662545). Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3 (PubMed:20175877). Negatively regulates the differentiation of T follicular helper cells T(FH)s (PubMed:24859450). Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (PubMed:23946441). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC220670 | Foxp1 (untagged) - Mouse forkhead box P1 (cDNA clone MGC:76591 IMAGE:30430449), (10ug) |
CNY 4,936.00 |
|
| MG209941 | Foxp1 (tGFP-tagged) - Mouse forkhead box P1 (cDNA clone MGC:76591 IMAGE:30430449) |
CNY 4,180.00 |
|
| MR209941L3 | Lenti ORF clone of Foxp1 (Myc-DDK-tagged) - Mouse forkhead box P1 (cDNA clone MGC:76591 IMAGE:30430449) |
CNY 7,328.00 |
|
| MR209941L4 | Lenti ORF clone of Foxp1 (mGFP-tagged) - Mouse forkhead box P1 (cDNA clone MGC:76591 IMAGE:30430449) |
CNY 7,328.00 |
