Nuak1 (NM_001004363) Mouse Tagged ORF Clone
CAT#: MR209827
- TrueORF®
Nuak1 (Myc-DDK-tagged) - Mouse NUAK family, SNF1-like kinase, 1 (Nuak1)
ORF Plasmid: tGFP
"NM_001004363" in other vectors (5)
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CNY 4,904.00
CNY 5,700.00
Cited in 1 publication. |
CNY 300.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | AU014801; AW494241; B230104P22Rik; Omphk1 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MR209827 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAAGGGGCGGCAGTGTCCGCGGCAGGGGATGGCCCTGCTGTAGAGACCGGCTTGCCGGGCTCTCCGC TGGAGGCGGTGGCCGGGGCGACTGCAGCCCCAGTGGAGCCCAGGAAGCCGCACGGGGTGAAGCGACATCA CCACAAACACAACTTGAAGCATCGCTATGAGCTGCAAGAGACCCTGGGCAAAGGTACCTACGGCAAAGTC AAGAGAGCCACCGAGAGGTTTTCAGGCCGAGTGGTTGCTATAAAATCCATCCGTAAGGACAAAATTAAGG ACGAGCTAGACATGGTTCACATCAGACGAGAGATTGAGATCATGTCATCCCTCAACCATCCTCATATCAT CAGTATTTATGAAGTGTTTGAGAACAAAGATAAGATTGTGATCATCATGGAATATGCCAGCAAAGGAGAG CTGTATGATTACATCAGTGAGCGCAGGCGCCTCAGCGAGAGGGAGACCAGACACTTCTTCCGGCAGATTG TGTCTGCCGTGCATTACTGTCACAAGAATGGTGTGGTCCACCGGGACTTGAAGCTGGAGAACATACTGCT TGATGACAACTGCAACATTAAGATTGCTGACTTTGGGCTCTCCAACCTGTACCAGAAGGACAAGTTCTTG CAAACATTTTGTGGGAGCCCACTCTATGCGTCGCCCGAGATTGTCAACGGCAGGCCTTACCGAGGGCCAG AGGTGGACAGCTGGGCCCTGGGTGTCTTGCTTTACACTCTCATTTATGGAACGATGCCCTTCGATGGCTT TGATCACAAAAACCTCATCCGGCAGATCAGCAGCGGAGAGTACCGGGAGCCCACACAACCCTCAGATGCT CGGGGACTCATCCGGTGGATGCTGATGGTGAATCCCGATCGCAGAGCCACCATCGAGGACATCGCCAACC ATTGGTGGGTGAACTGGGGCTACAAGAGCAGCGTCTGTGACTGTGATGCCCTTCCTGACTCTGAGTCTCC ACTCTTGGCACGGATCATCGATTGGCATCACCGTTCCACGGGGCTGCAGGCTGAGGCTGAAGCCAAGATG AAGGGTCTGGCCAAACCCGGGGCCTCTGAGGTTGTGTTGGAGCGGCAGCGGTCACTGAAGAAGTCCAAGA AAGAGAACGACTTTCCCCAGTCTGGCCAGGACTCCGTACCTGAAAGCCCATCCAAGCTGAGTTCCAAGAG GCCCAAGGGCATCCTGAAGAAACGGAGCAACAGCGAACACCGCTCCCACAGCACTGGCTTTATCGAAGGC ATTGTGAGCCCTGCCTTACCATCCCCTTTCAAAATGGAGCAAGATTTGTGCCGGACTGCCATCCCCCTCC CCAGCTCCCCCGAGGCAGATATGTCAGGGAAGCTCAGCCTCAAACAGTCTGCCACGATGCCCAAGAAAGG CATCTTGAAAAAGACCCAGCAGAGAGAATCTGGCTACTATTCATCCCCAGAGCGCAGCGAGTCCTCGGAA CTGCTGGACAGCAACGATGTGGTCATCAGTGGTGGCCTCTCGTCCCCTCCCCCAGACCCAGCCAGGGGAA CTTCCCACAGCCTGTCCTGCCGGAGGAAGGGCATCTTAAAACATAGTAGCAGGTACTCAGATGGTGGCAC AGACCCTGCCCTCACCCGCCCTGAAATGCCCACACTGGAATCCTTGTCACCTCCCGGTGTCCCCTCCGAT GGCATCTCTCGGAGCTACAGTCGCCCGTCCAGTATCATCAGTGATGACAGTGTCCTGTCCAGCGACTCTT TCGACTTGTTAGAGCTTCAAGAGAACCGGCCAGCCCGCCAGCGCATCCGCAGCTGCGTCTCTGCTGAAAA CTTCCTCCAGCTTCAGGACTTTGAGACACCACACAACCGGCCCCGGCCCCAGTACCTGAAGCGGCTGGCA GACAGTAGCTTCTCCCTTCTCACTGATATGGACGATGTGACTCAGGTGTATAAGAAAGCGCTGGAGATCT GCAGCAAGCTCAAC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR209827 protein sequence
Red=Cloning site Green=Tags(s) MEGAAVSAAGDGPAVETGLPGSPLEAVAGATAAPVEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKV KRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGE LYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFL QTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPSDA RGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKM KGLAKPGASEVVLERQRSLKKSKKENDFPQSGQDSVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEG IVSPALPSPFKMEQDLCRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSE LLDSNDVVISGGLSSPPPDPARGTSHSLSCRRKGILKHSSRYSDGGTDPALTRPEMPTLESLSPPGVPSD GISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQYLKRLA DSSFSLLTDMDDVTQVYKKALEICSKLN TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_001004363 |
ORF Size | 1977 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001004363.2 |
RefSeq Size | 5032 bp |
RefSeq ORF | 1977 bp |
Locus ID | 77976 |
UniProt ID | Q641K5 |
MW | 73.7 kDa |
Gene Summary | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.[UniProtKB/Swiss-Prot Function] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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High-Throughput Kinase Inhibitor Screening Reveals Roles for Aurora and Nuak Kinases in Neurite Initiation and Dendritic Branching
,Blazejewski, S;Bennison, S;Liu, X;Toyo-oka, K;,
bioRxiv
[NUAK1]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MG209827 | Nuak1 (tGFP-tagged) - Mouse NUAK family, SNF1-like kinase, 1 (Nuak1) |
CNY 6,270.00 |
|
MR209827L1 | Lenti ORF clone of Nuak1 (Myc-DDK-tagged) - Mouse NUAK family, SNF1-like kinase, 1 (Nuak1) |
CNY 7,600.00 |
|
MR209827L2 | Lenti ORF clone of Nuak1 (mGFP-tagged) - Mouse NUAK family, SNF1-like kinase, 1 (Nuak1) |
CNY 7,304.00 |
|
MR209827L3 | Lenti ORF clone of Nuak1 (Myc-DDK-tagged) - Mouse NUAK family, SNF1-like kinase, 1 (Nuak1) |
CNY 7,600.00 |
|
MR209827L4 | Lenti ORF clone of Nuak1 (mGFP-tagged) - Mouse NUAK family, SNF1-like kinase, 1 (Nuak1) |
CNY 7,600.00 |