United States
Germany
Japan
United Kingdom
China
Atrx (NM_009530) Mouse Tagged ORF Clone
CAT＃: MG226423
- TrueORF®
Atrx (tGFP-tagged) - Mouse alpha thalassemia/mental retardation syndrome X-linked homolog (human) (Atrx), (10ug)
ORF Plasmid: DDK
"NM_009530" in other vectors (2)
Need custom modification / cloning service?
Get a free quote
CNY 27,170.00
货期*
9周
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | 4833408C14Rik; AI447451; ATR2; DXHXS6677E; HP1-BP38; Hp1bp2; Hp1bp38; MRXS3; Rad54; RAD54L; XH2; Xnp |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MG226423 representing NM_009530
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGACCGCTGAGCCCATGAGTGGAAACAAGTTGAGTACATTGGTGCAGAAGCTTCATGACTTCTTAGCAC ACTCATCAGAAGAATCTGAGGAAACGTGTTCTTCTCCACGACTTGTCATGAACCAAAGCACAGATAAAAT CTGTGGTTCTGGACTTAATTCTGATATGATGGAAAATAACAAGGAAGAGGGAGCTAGCACCTCAGAAAAA TCCAGATCTTCAGGTTCATCAAGGTCAAAGAGGAAACCTTCAATTGTGACAAAATATGTAGAATCTGATG ATGAAAAACCCACGGATGAGAATGTAAATGAAAAAGCTGCTACTGAGAATTCAGAAAATGACATTACTAT GCAAAGCTTGCCAAAAGGTACAGTGATTGTACAACCAGAGCCAGTGCTGAATGAAGACAAAGATGATTTT AAAGGGCCTGAATTTAGAAGCAGAAGTAAAATGAAAGCTGACAATCTCAAAAAACGCGGAGAAGATGGAC TTCATGGGATCGTGAGCTGCACAGCTTGTGGACAGCAGGTCAATCATTTTCAAAAAGATTCCATTTATAG ACACCCTTCACTCAAAGTCCTTATCTGTAAGAACTGCTTTAAGTATTATATGAGTGACGATATTAGCCGT GACTCAGATGGAATGGATGAACAATGTAGATGGTGTGCAGAAGGTGGGAACTTGATTTGTTGTGACTTTT GTCATAACGCCTTCTGTAAGAAATGCATCCTGCGCAACCTTGGTCGAAAGGAGTTGTCTACAATAATGGA TGAAAACAATCAGTGGTATTGCTATATTTGTCAACCAGAGCCTCTACTGGACTTGGTGACTGCGTGCAAC AGCGTATTTGAGAATTTAGAACAGTTGTTGCAACAGAATAAGAAGAAGATAAAAGTTGACAGTGAAAAGA CTAGTAAAGTCTGTGACCAAACATCCAAATTTTCTCCAAAGAAGAGTAGTTCTAGTTGTAATGGAGAAGA AAAAAAGTTAGAGGAGTCCTGTTCTGGTTCTGTAAGCTCCACTTACTCTCACTCAGCACTATCTGTGCCC AAAGAGATGATTAAGAAGACAACAAAACTGATTGAGACTACATCCAACATGAACTCCAGTTACATTAAGT TTCTAAAACAGGCAGCAGATAATTCAGAAATGACTTCTGCTATGAAGTTATGTCAACTTAAGTCTTTTAA ATCTGTGTTGGATGATATCAAGAAGGCTCATCTTGCATTAGAAGAAGATTTGAATTCAGAGATCCAAGCT TTGGATGATGTACACAAAGAAAAAAATACCAAAGACCTTAAAAGCACAGATGCTAAGTCTGAAACAAAAT TAGGAAAAGGGGAAAAATCCTATTCTACAGAAAAGAGAGAGTTTTTAAAGTTAGATGCTAGATCATCAGT AAAGGCCATAGATGGTGAAGAGCAGAGAGCACACAAAAGTACTAGTGGGGAACATAAGGGTTCAGGTAGG AAAGATGGCTCTCAGTATGAACCCACTAACACTCCTGAGGATTTAGATATGGATATTGTGTCTGTTCCTT CCTCGGTTCCAGAAGACATTTTTGATAGCCTTGAGAGTGCTATGGAAGTTCAGAGTTCAGCTGATTATCA AGGAGACGGCAACAGTGGGACTGAGCCAGAACTGGAGAGCTCCTCTGTAAAATTAAATGTTTCTTCAAAA GACAGCAGAGGAAATATTAAGTCAAAAGTCACAGCGAAAGTAAGAAAAGAATTATTTGTTAAACTTACCC CAGTTTCCCTTTCTAATTCCCCAATTAAAGGTGTTGACTGTCAGGAAGTGTCACAAGAGAAGAATGGCCG TAAAAGTTCTGGGGTGGCCCGCAGCTCAGAGAAATGTAGACCCAGAGAGGAAATTAGTGATCATGAAAAC AATGTCACAATACTTTTAGAAGACTCCGATCTTCGAAGATCCCCACGTGTAAAAACTACACCGTTGAGGC GACAGACAGAAAGCAACCCTGCAATGTCGAATTCAGATGAAGAAAGTAATGGAACTATGAAGGAGAAACA AAAGATGTCAGGTCCAATAAGAAAAAAGGATAAGAGAAACTCAGCTGACTGTGCTACTGATAACCCTAAA CCTCACAAGGTACCCAAAGCTAAGCAACCAGTGATTGGGGATCAGAATTCAGATTCTGATGAAATGCTAG CAGTCCTCAAAGAGGCAAGTCAGATGGGGCATAGTTCTTCCTCAGACACTGACATTAATGAACCACAGAT GAATCATAAAGGTAAAACAGGGAAAGATGATAATGGAAAAAGGAAACGGAAAAATTCTACTTCCGGGTCA GATTTTGACACTAAAAAAGGAAAATCAACAGAAACCTCTATTATCTCTAAAAAGAAACGCCAGAACTACT CAGAGTCCTCTAACTATGACTCAGAGTTAGAGAGAGAGATAAAAACCATGAGCAGAATTGGGGCTGCCAG AAAAAGTGTTCCAGAGAAAAAAGAAGAGGACTCTTCTGAAGATGAAAAACAGGGCAAAAAAGTAGTGGAT AATGGAGGGCATGAGAGGGCGAAGACAACACAAGAAGGGTCATCTGCTGATGACACTGGTGACACTGAAG GCAGGCAGGGAGGGAGTTGCTCCATAGCAGGAGGTTCCATTGAGAAAGTCAGGAGTGGAGTGGAATTCCG AGAGATGCTTTGCAAACCTGGTGTTTCCTCTGATGGTGCTGAAAAGCCTTCAGTGAAAGAGGAGAACGTG AATTCCCCTGAAGACAAAAGAGTCTCTAAGACTAAAGAAAAGACTAAACATCTGAGAAGCAGACAAAGTA GAAAAGGAAAGGGTGGGTCATCTGATGGCACTGATCGATTTCCAAAGAAAGAGCAGAGCGATGAGTCTTC TGAAGGCGAAAAGAAGCAGAGCAGACAGAGACCTGGAACAAAAGGAAAGAAAGCCCCAGACTTAAAGGGA GAAACACTGAAGCGAGAGCAGGAGTGGGACTCTTCCTCTGATGGGACCGAGAGATTGCCGGAGGAAGAGG AGATTGGTCCTTTTTCTAAAGGCATAAAGCAAAGTAAAACTGACACAGCTGGTGGAGAAAAGAAAGGCAA AAAATGGAAAGATAAATCATGTGAAAAGAAGGAAGAATTATCTGATAGTGTTGATAAATTGCCAGGAAAA GGAGATAGTTGTGACTCTTCCGAAGATAAGAAGACCAGGAACAGAGTGTCTCTGAGAGAGAAGAAACGAT TCAGCTTGCCTGCAAAGAGTCCAGGGAAGAGGCCAGAGTGTTCATCGTCAGATACTGAGAAATCCTTGAA AGGACAGTGTTGTGACTCCACTGAAAAGAGACCGAAAAGAATTGACTTGAGAGAAAGAAGAAACTCCAGT TCAAAGAGAAATACCAAGGAAGTAAAGAGTGCTTCATCCTCTTCTGATGCTGAGGGAAGCTCAGAAGATA ATAAAAAGCAGAAGAAACAAAGAACTTCAGCCAAAAAGAAGACAGGCAATACGAAGGAGAAAAAAAGAAA CTCCTTAAGAGCAACTCCTAAAAGGAAGCAAGTAGACATCACTTCTTCATCTTCTGATATAGGAGATGAT GATCAGAATTCTGCAGGCGAGGAAAGCAGCGATGAACAGAAAATCAAACCCGTGACTGAAAATCTAGTGC TGCCTTCACACACTGGATTTTGTCAGTCTTCAGGAGATGAAGCCTTATCTAAATCAGTGCCTGCCACAGT GGATGATGACGACGACGACAATGATCCTGAAAATAGAATTGCCAAGAAGATGCTTTTAGAAGAAATTAAA GCCAATCTTTCCTCTGATGAGGATGGGTCGTCAGATGATGAACCTGATGGAGGAGGGAAAAAAAGAATTG GGAAACAGAGTGAAGAATCTCCAGCAGATGATGGTGAACTCCGCAGAGAGCAGTTAGCCGTGAATCAAGT CAACTCTGAATCCGACTCTGATTCTGAAGAATCTAAGAAGCCAAGATACAGACATAGGCTTTTGAGGCAT AAACTGACTTTGAGTGATGGAGAATCTGGAGAAGAAAAACCTACTAAGCCTAAAGAGCATAAAGAAGCCA AAGGAAGAAATAGAAGGAAGGTGAGCAGTGAGGATTCAGAAGACACCGACTTTCAGGAGTCAGGAGTTAG CGAAGAAGTCAGTGAATCTGAGGATGAACAGCGGCCTAGAACACGGTCTGCAAAGAAAGCAGAATTGGAA GAAAATCAGCGGAGTTATAAACAGAAGAAGAAAAGACGGCGCATTAAGGTTCAAGAGGATTCCTCCAGTG AAAATAAGAGCCATTCTGAGGAGGACAAGAAGGAAGGTGATGAGGAGGACGAGGAGGACGAGGACGAAGA CGAGGAAGATGAAAATGATGATTCCAAGTCACCTGGAAAAGGCAGAAAGAAAATTCGGAAGATTCTTAAA GATGATAAACTAAGAACAGAAACACAGAATGCCCTTAAAGAAGAGGAAGAAAGGCGAAAACGTATTGCAG AGAGGGAACGTGAAAGGGAGAAATTGAGAGAGGTGATAGAAATTGAGGATGCTTCACCTACTAAGTGTCC AATAACAACCAAATTGGTTTTAGATGAAAATGAAGAGACCAAAGAACCGTTAGTGCAGGTTCATAGAAAC ATGGTTATAAAATTGAAACCCCATCAAGTAGATGGTGTTCAGTTTATGTGGGATTGCTGCTGTGAGTCTG TGGAAAAGACAAAGAAGTCCCCAGGTTCAGGATGTATTCTTGCCCACTGCATGGGCCTTGGTAAGACCCT CCAGGTGGTTAGTTTTCTTCACACAGTTCTTCTGTGTGACAAATTGGATTTCAGTACAGCTTTAGTGGTT TGTCCTCTTAACACTGCTTTGAATTGGATGAATGAATTTGAGAAGTGGCAGGAGGGATTAAATGATAATG AAAAACTTGAGGTATCTGAGTTAGCAACTGTGAAACGTCCTCAGGAGAGAAGTTATATGCTACAGAGATG GCAAGAAGATGGTGGTGTTATGATCATAGGGTATGAAATGTACAGAAATCTCGCTCAAGGAAGAAATGTG AAAAGTCGGAAACTTAAAGACATATTTAATAAAGCTTTAGTTGACCCAGGCCCTGATTTTGTTGTTTGTG ATGAAGGCCATATTCTAAAAAATGAAGCATCTGCTGTTTCAAAAGCTATGAACTCTATAAAATCAAGGAG GAGGATTATTTTAACAGGAACACCACTTCAAAATAACCTAATTGAATATCATTGCATGGTTAACTTTATC AAGGAAAATTTGCTTGGATCCATCAAGGAATTCAGGAATAGATTTATAAATCCAATCCAAAATGGACAGT GTGCAGATTCTACCATGGTAGATGTGAGAGTGATGAAAAAACGTGCTCATATTCTCTATGAGATGTTAGC CGGATGTGTTCAGAGGAAAGATTACACAGCGCTAACAAAGTTCTTACCTCCAAAACATGAGTATGTGTTA GCTGTGAGAATGACTGCTATTCAGTGCAAGCTCTATCAATACTACTTAGATCACTTAACAGGTGTGGGCA ATAGCACTGAAGGTGGAAGAGGAAAGGCAGGTGCAAAGCTTTTTCAAGATTTCCAAATGTTAAGTAGAAT CTGGACTCATCCTTGGTGTTTGCAACTGGACTATATCAGCAAAGAAAATAAGGGTTATTTTGATGAAGAT AGTATGGATGAATTTATAGCTTCAGATTCTGATGAAACCTCTAAGAGTTTAAGCTCAGATGAAAAGAAGA AACCAAAGGGGAAGAAGGGGAAAAAGGACAGCAGCTCAAGCGGAAGTGGCAGTGACAACGATGTTGAAGT CATCAAAGTCTGGAATTCAAGATCTCGAGGAGGTGGAGATGGCAACGTGGATGACACAGGAAATAACCCT TCAGTTTCTCTGAAGCTAGATGAAAGTAAAACTACTTCCACTTCTAACCCAAGTAGCCCAGCTCCAGATT GGTACAAAGATTTTGTTACAGATACTGATGCTGAGGTTTTAGAACATTCTGGAAAAATGGTGCTTCTTTT TGAAATTCTTCGAATGGCAGAAGAAATTGGGGATAAAGTTCTTGTTTTTAGCCAGTCGCTCATATCTCTG GACTTGATTGAAGATTTTCTTGAATTGGCTAGTAGGGAGAAAACAGAAGATAAAGAAAAACCTCTTATTT ATAAAGGTGAAGGAAAGTGGATCCGAAATATTGACTATTACCGCTTGGATGGTTCTACTAATGCACAGTC AAGGAAGAAGTGGGCTGAAGAATTTAATGATGAAACCAATGTGAGAGGGCGATTGTTTATCATTTCCACT AAAGCAGGATCTCTTGGAATTAACCTGGTAGCTGCTAATAGAGTGATTATATTTGATGCTTCTTGGAATC CATCTTATGACATCCAGAGTATATTCAGAGTTTATCGCTTTGGACAAACTAAGCCTGTTTATGTATATAG GTTCTTAGCTCAGGGAACCATGGAAGATAAGATTTATGATCGTCAGGTAACAAAGCAGTCACTGTCTTTC CGCGTTGTGGATCAACAGCAGGTTGAGCGCCATTTTACCATGAATGAGCTTACTGAACTTTATACTTTTG AGCCAGACTTACTAGATGACCCGAATTCAGAAAAGAAGAAGAAAAGGGATACCCCCATGCTGCCAAAGGA TACCATACTTGCAGAACTTCTTCAGATACATAAAGAGCACATTGTGGGCTATCATGAACATGATTCTCTT TTGGATCACAAAGAAGAAGAAGAACTAACTGAAGAAGAAAGAAAAGCAGCTTGGGCTGAATATGAAGCAG AAAAGAAGGGACTGACCATGCGTTTCAACATACCAACTGGGACCAATTTACCCCCTGTCACTTTCACCTC TCAAACTCCTTATATTCCTTTCAATTTGGGAGCCCTGTCCGCAATGAGTAATCAGCAGCTGGAGGACCTT ATTAATCAAGGAAGAGAAAAAGTTGTAGAAGCCACGAACAGTATGACGGCAGTGAGGATTCAGCCTCTTG AAGACATCATTTCAACTGTATGGAAAGAAAACATGAATCTCTCTGAGGCCCAAGTCCAAGCACTAGCATT AAGTAGACAAGCCAGCCAGGAGCTTGACGTGAAACGAAGAGAAGCAATCTACAACGATGTATTGACAAAG CAACAGATGTTGATCAACTGTGTTCAGCGAATACTTATGAATAGACGGCTCCAGCAGCAGTACACTCAGC AGCAACAGCAACAATTGACTTATCAGCAAGCAACACTGAGTCACCTCATGATGCCAAAGCCTCCAAATTT AATCATGACTCCTTCTAACTACCAGCAGATTGATATGAGAGGAATGTATCAGTCAGTGGCTGGTGGTATG CAGCCACCACCCTTACAGCGTGCACCGCCCCCCACAGTGAGAAGCAAAAATCCAGGACCTTCCCCAGGGA AATCAATG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG226423 representing NM_009530
Red=Cloning site Green=Tags(s) MTAEPMSGNKLSTLVQKLHDFLAHSSEESEETCSSPRLVMNQSTDKICGSGLNSDMMENNKEEGASTSEK SRSSGSSRSKRKPSIVTKYVESDDEKPTDENVNEKAATENSENDITMQSLPKGTVIVQPEPVLNEDKDDF KGPEFRSRSKMKADNLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLKVLICKNCFKYYMSDDISR DSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICQPEPLLDLVTACN SVFENLEQLLQQNKKKIKVDSEKTSKVCDQTSKFSPKKSSSSCNGEEKKLEESCSGSVSSTYSHSALSVP KEMIKKTTKLIETTSNMNSSYIKFLKQAADNSEMTSAMKLCQLKSFKSVLDDIKKAHLALEEDLNSEIQA LDDVHKEKNTKDLKSTDAKSETKLGKGEKSYSTEKREFLKLDARSSVKAIDGEEQRAHKSTSGEHKGSGR KDGSQYEPTNTPEDLDMDIVSVPSSVPEDIFDSLESAMEVQSSADYQGDGNSGTEPELESSSVKLNVSSK DSRGNIKSKVTAKVRKELFVKLTPVSLSNSPIKGVDCQEVSQEKNGRKSSGVARSSEKCRPREEISDHEN NVTILLEDSDLRRSPRVKTTPLRRQTESNPAMSNSDEESNGTMKEKQKMSGPIRKKDKRNSADCATDNPK PHKVPKAKQPVIGDQNSDSDEMLAVLKEASQMGHSSSSDTDINEPQMNHKGKTGKDDNGKRKRKNSTSGS DFDTKKGKSTETSIISKKKRQNYSESSNYDSELEREIKTMSRIGAARKSVPEKKEEDSSEDEKQGKKVVD NGGHERAKTTQEGSSADDTGDTEGRQGGSCSIAGGSIEKVRSGVEFREMLCKPGVSSDGAEKPSVKEENV NSPEDKRVSKTKEKTKHLRSRQSRKGKGGSSDGTDRFPKKEQSDESSEGEKKQSRQRPGTKGKKAPDLKG ETLKREQEWDSSSDGTERLPEEEEIGPFSKGIKQSKTDTAGGEKKGKKWKDKSCEKKEELSDSVDKLPGK GDSCDSSEDKKTRNRVSLREKKRFSLPAKSPGKRPECSSSDTEKSLKGQCCDSTEKRPKRIDLRERRNSS SKRNTKEVKSASSSSDAEGSSEDNKKQKKQRTSAKKKTGNTKEKKRNSLRATPKRKQVDITSSSSDIGDD DQNSAGEESSDEQKIKPVTENLVLPSHTGFCQSSGDEALSKSVPATVDDDDDDNDPENRIAKKMLLEEIK ANLSSDEDGSSDDEPDGGGKKRIGKQSEESPADDGELRREQLAVNQVNSESDSDSEESKKPRYRHRLLRH KLTLSDGESGEEKPTKPKEHKEAKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELE ENQRSYKQKKKRRRIKVQEDSSSENKSHSEEDKKEGDEEDEEDEDEDEEDENDDSKSPGKGRKKIRKILK DDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDENEETKEPLVQVHRN MVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVV CPLNTALNWMNEFEKWQEGLNDNEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNV KSRKLKDIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFI KENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVL AVRMTAIQCKLYQYYLDHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDED SMDEFIASDSDETSKSLSSDEKKKPKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGDGNVDDTGNNP SVSLKLDESKTTSTSNPSSPAPDWYKDFVTDTDAEVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISL DLIEDFLELASREKTEDKEKPLIYKGEGKWIRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIIST KAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSF RVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSL LDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQTPYIPFNLGALSAMSNQQLEDL INQGREKVVEATNSMTAVRIQPLEDIISTVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTK QQMLINCVQRILMNRRLQQQYTQQQQQQLTYQQATLSHLMMPKPPNLIMTPSNYQQIDMRGMYQSVAGGM QPPPLQRAPPPTVRSKNPGPSPGKSM TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_009530 |
| ORF Size | 7428 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_009530.2, NP_033556.2 |
| RefSeq Size | 10244 bp |
| RefSeq ORF | 7431 bp |
| Locus ID | 22589 |
| UniProt ID | Q61687 |
| Gene Summary | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells probably implying recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according (PubMed:20211137) is required for its transcriptional repression in embryonic stem cells. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
You may also need
Customer
Reviews
Loading...
