Aqr (NM_001290788) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	AW495846; mKIAA0560
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC229578 representing NM_001290788 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGGCTCCTGCGCAGCCCAAGAAAATCGTGGCCCCCACGGTGTCCCAGATCAACGCGGAGTTCGTCA CTCAGCTAGCATGTAAATACTGGGCTCCTCATATCAAGAAGAAATCACCGTTTGATATAAAAGTAATTGA AGAAATATATGAAAAAGAGATCGTCAAATCACGGTTTGCCATCAGGAAAATAATGCTGCTGGAATTTAGC CAATACCTTGAAAATTATCTTTGGATGAATTATTCTCCGGAAGTTTCCAGCAAGGCCTATTTAATGTCCA TCTGCTGTATGGTGAATGAGAAGTTCAGAGAAAATGTCCCAGCCTGGGAGACCTTTAAGAAGAAACCAGA CCACTTCCCATTCTTTTTTAAGTGCATCTTGAAAGCGGCCTTAGCTGAGACTGACGGCGAGTTCTCCCTC CACGAGCAGACACTGCTCCTGCTTTTCCTGGATCACTGCTTCAATAGCTTGGAAGTAGACTTGATAAGGA GTCAGGTGCAGCAGCTTATCTCGCTCCCGATGTGGATGGGCTTGCAGCCTGCACGATTGGAATTAGAATT GAAAAAGACACCAAAGCTAAGAAAATTCTGGAACCTGATTAAAAAGAATGATGAAAAGATGGACCCAGAA GCAAGAGAGCAGGCCTACCAAGAAAGAAGGTTTCTCTCCCGGCTCATCCAGAAGTTCATCTCCGTGTTGA AGTCCATCCCGCTTTCTGAGCCTGTCACCATGGACAAGGTTCATTACTGTGAAAGATTCATCGAACTGAT GATTGATCTAGAGGCTCTACTCCCCACGAGGCGCTGGTTTAACACCATCCTGGATGACTCCCACCTTCTG GTTCACTGCTACCTCTCCAGTCTTGTTCACAGAGAAGAGGACGGCCATCTGTTTTCCCAGCTTTTAGACA TGCTGAAGTTCTATACTGGCTTTGAGATTAACGACCAGACTGGAAATGCTCTGACAGAGAACGAGATGAC CACGATTCACTATGACAGAATTACATCTCTGCAGAGGGCTGCCTTCGCACACTTCCCCGAGCTCTATGAC TTTGCCCTCTCCAATGTGGCAGAAGTAGATGCCCGAGATTCCTTGGTCAAGTTTTTTGGGCCTCTCAGTT CAAACACACTCCACCAGGTGGCATCATACCTCTGCCTCTTGCCAACGCTCCCTAAAAATGAAGACACAAC TTTTGATAAAGAGTTTCTTCTAGAATTGCTGGTGTCTCGCCACGAACGCCGCATCTCTCAAATTCAGCAA CTGAATCAGATGCCTTTGTATCCAACTGAGAAAATTATATGGGATGAGAACATCGTCCCTACTGAGTACT ATTCTGGGGAAGGCTGCCTTGCTCTCCCCAAGTTGAATCTGCAGTTTTTGACTCTGCACGACTATCTCCT GAGGAACTTCAATCTCTTCCGCTTAGAGTCAACTTACGAAATTAGACAAGACATCGAGGACAGTGTCAGC AGAATGAAGCCCTGGCAGTCTGAGTATGGTGGCGTAGTGTTCGGTGGTTGGGCACGGATGGCCCAGCCCA TTGTGGCTTTCACTGTAGTCGAGGTTGCCAAACCCAACATCGGTGAAAACTGGCCAACCCGAGTTCGTGC AGATGTCACCATCAATCTGAATGTCAGAGACCACATCAAGGATGAGTGGGAAGGTCTTCGAAAGCACGAT GTATGCTTTTTAATTACTGTGCGTCCAACAAAACCTTACGGCACTAAGTTTGACAGGAGGAGACCTTTTA TTGAGCAAGTTGGTCTGGTGTACGTCAGAGGCTGTGAAATCCAGGGCATGCTGGATGACAAAGGGCGAGT CATCGAAGACGGACCTGAACCCAGACCCAATCTTAGAGGAGAGTCAAGGACATTTCGAGTATTTTTGGAT CCAAACCAGTATCAACAGGATATGACCAATACGATACAAAACGGAGCCGAAGATGTGTATGACACTTTCA ATGTCATAATGAGGAGGAAACCGAAGGAGAATAACTTCAAGGCTGTGTTGGAGACGATTCGGAATCTGAT GAATACTGACTGCGTGGTACCGGACTGGCTGCATGACATCATTTTGGGCTATGGGGACCCAAGTAGTGCC CATTATTCAAAAATGCCCAATCAGATTGCCACCCTGGATTTCAATGACACTTTTCTCTCCATTGAACATT TAAAGGCCAGCTTTCCTGGTCATAATGTCAAAGTGACTGTGAGTGACCCAGCACTCCAAATCCCCCCTTT CAGAATAACGTTCCCAGTAAGAAGTGGAAAGGGGAAGAAAAGAAAAGATGCAGACGGGGAAGAAGATGAC ACAGAAGAAGCAAAGACCTTAATTGTGGAGCCTCATGTTATTCCTAATAGAGGCCCTTATCCTTACAACC AGCCCAAACGTAATACAATCCAGTTCACTCATACACAGATAGAGGCCATCCGGGCCGGAATGCAGCCTGG ACTCACCATGGTTGTGGGCCCACCTGGTACAGGAAAAACAGATGTTGCAGTCCAGATCATATCCAACATT TACCACAATTTCCCAGAACAGAGGACTTTAATTGTTACTCATTCCAATCAGGCTCTGAACCAGCTGTTTG AGAAAATCATGGCTTTAGACATTGATGAGCGCCATCTCCTGCGTCTGGGTCATGGAGAAGAAGAGCTAGA GACAGAGAAAGACTTTAGCAGGTATGGAAGAGTTAATTATGTCCTAGCTCGAAGAATAGAACTTTTAGAA GAAGTCAAACGGTTACAAAAGAGTCTGGGGGTTCCCGGAGATGCTTCGTATACCTGTGAAACTGCCGGCT ATTTCTTCTTATATCAGGTGATGTCCCGCTGGGAAGAATACATGAGCAGAGTGAAGAACTCGGGGACTGC CTGCCCGGACGCTGCCCCGGACGCTGCACAGGTCGCCACGTTCTTCCCCTTCCATGAGTATTTTGCCAAT GCTCCTCAGCCCATCTTTAAAGGCAGATCTTATGAGGAAGACATGGAAATCGCTGAAGGGTGCTTCAGGC ACATTAAGAAAATCTTCACCCAACTTGAGGAGTTCAGAGCCTCGGAGCTGCTTCGCAGTGGACTGGACAG ATCCAAATACCTCTTGGTAAAAGAAGCCAAAATCATCGCTATGACATGTACTCATGCTGCCTTGAAACGA CACGACTTGGTCAAGTTGGGTTTCAAGTATGACAACATTTTAATGGAAGAGGCTGCTCAGATTCTGGAGA TCGAAACCTTTATCCCTCTACTTCTGCAGAATCCTCAAGACGGATTCAGCCGATTGAAACGGTGGATTAT GATTGGCGATCACCACCAATTGCCTCCAGTCATTAAGAACATGGCCTTTCAGAAGTATTCCAACATGGAG CAGTCTCTTTTCACTCGCTTCGTCCGGGTTGGAGTTCCTACTGTGGACCTTGATGCTCAAGGGAGAGCCA GGGCAAGCTTGTGTAACCTCTACAACTGGCGCTACAAAAACCTAGGGAATTTGCCCCATGTGCAGCTCCT GCCAGAGTTCAGCACAGCCAACGCGGGCCTGCTGTATGACTTCCAGCTCATCAACGTGGAAGACTTTCAG GGCGTGGGAGAGTCGGAGCCTAACCCTTACTTCTACCAGAACCTTGGAGAGGCAGAGTATGTAGTGGCGC TCTTCATGTACATGTGCTTGCTTGGTTACCCTGCAGACAAGATCAGTATTCTAACAACCTACAATGGACA GAAGCATCTGATTCGGGACATCATCAATAGGCGCTGTGGGAATAATCCACTGATTGGAAGGCCAAACAAA GTGACAACAGTTGACAGATTCCAGGGTCAGCAGAACGATTATATCCTCCTTTCGCTAGTGCGGACCAGGG CTGTGGGTCATCTGAGGGATGTGCGTCGCTTGGTGGTAGCCATGTCAAGAGCCAGGCTTGGCCTTTACAT CTTCGCTCGAGTGTCCCTCTTCCAGAACTGCTTTGAACTGACTCCTGCTTTCAGCCAGCTCACTGCCCGC CCACTGCATTTGCATATCATTCCAACAGAACCCTTCCCAACCTCCAGAAAGGCTCTTCCTTCTCCGGCAC TTCTCTTGCCAGAGCTGCAGACACTGGATCATGCTCGGAGTGTGGCTGTTTTCTTCCAGCTGCAGAGTTC ACTGTTCTGCTCTTTTCACTGGATGAAATGTCCCAGAGATCTAGGAAATTTCAATAAACAGACAGTTTTA TAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001290788
Insert Size	4203 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001290788.1, NP_001277717.1
RefSeq Size	4414 bp
RefSeq ORF	4203 bp
Locus ID	11834
UniProt ID	Q8CFQ3
Gene Summary	Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks two 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

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