Dab2ip (NM_001290639) Mouse Untagged Clone
CAT#: MC229329
Dab2ip (untagged) - Mouse disabled 2 interacting protein (Dab2ip), transcript variant 6
CNY 10,260.00
货期*
5周
规格
Product images
经常一起买 (3)
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | 2310011D08Rik; AI480459; Aip1; mKIAA1743 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC229329 representing NM_001290639
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCCAAGGCTGAAGGAGTCTCGGTCACACGAGTCCCTGCTCAGCCCCAGCAGCGCAGTGGAGGCCCTGG ACCTCAGCATGGAGGAGGAGGTGATTATCAAGCCCGTTCACAGCAGCATCCTGGGTCAGGACTACTGCTT CGAGGTGACAACATCATCAGGAAGCAAGTGTTTTTCCTGCCGGTCAGCCGCTGAGCGCGATAAGTGGATG GAGAACCTGAGGCGAGCAGTGCACCCCAACAAGGACAACAGCCGGCGTGTGGAGCATATCCTGAAGCTGT GGGTGATTGAGGCCAAGGATCTGCCGGCCAAGAAGAAGTATCTATGTGAACTGTGCCTGGACGATGTGCT GTATGCCCGTACCACAAGCAAGCTCAAGACGGACAATGTCTTCTGGGGAGAGCACTTTGAGTTCCATAAC CTGCCGCCTCTACGCACAGTCACTGTGCACCTGTATCGGGAGACTGACAAGAAAAAGAAAAAGGAACGCA ACAGCTACCTGGGCCTGGTGAGCCTGCCTGCCGCCTCTGTGGCTGGGCGGCAGTTTGTGGAGAAGTGGTA CCCAGTGGTGACACCCAACCCCAAGGGTGGCAAAGGCCCTGGGCCCATGATCCGAATCAAGGCACGCTAC CAGACCGTCAGCATCTTGCCTATGGAGATGTACAAGGAGTTTGCGGAGCACATCACTAACCACTACCTGG GGCTGTGCGCAGCCCTGGAACCCATCCTCAGTGCCAAGACCAAGGAGGAGATGGCGTCGGCTCTGGTGCA CATCCTGCAGAGCACGGGAAAGGTGAAGGACTTTCTAACAGACCTGATGATGTCAGAGGTGGACCGCTGT GGGGACAATGAGCACCTCATCTTCCGGGAGAACACACTGGCCACCAAGGCCATCGAGGAATACCTCAAAC TTGTGGGCCAGAAGTACCTGCAGGACGCACTAGGTGAGTTCATCAAAGCTCTGTATGAGTCAGATGAAAA TTGTGAAGTGGACCCAAGCAAGTGCTCATCCGCTGACCTCCCTGAGCACCAGGGCAACCTCAAGATGTGC TGTGAGCTGGCCTTCTGCAAGATCATCAACTCCTACTGCGTCTTCCCACGGGAGCTTAAGGAGGTGTTCG CCTCATGGCGGCAGGAGTGTAGCAGCCGAGGCCGGCCAGATATCAGTGAACGGCTCATCAGCGCCTCCCT CTTCCTTCGCTTCCTGTGCCCTGCCATCATGTCACCCTCGCTCTTCAACCTGCTTCAGGAGTATCCTGAC GACCGCACGGCTCGCACCCTCACGCTCATTGCCAAAGTCACCCAGAACCTGGCCAACTTTGCCAAGTTTG GCAGCAAGGAAGAATACATGTCCTTCATGAACCAGTTCCTGGAGCACGAGTGGACCAACATGCAGCGCTT CCTGTTGGAGATCTCCAACCCCGAGACCCTTTCCAACACAGCAGGCTTCGAGGGCTACATAGACCTGGGC CGGGAGCTCTCTAGCCTGCACTCCCTGCTCTGGGAAGCTGTCAGCCAGCTTGATCAGAGCGTTGTGTCGA AGCTGGGACCTCTGCCTCGTATCCTGAGGGATGTCCACACAGCACTGAGCACTCCTGGCAGTGGGCAGCT CCCTGGCACCAATGACCTGGCCTCCACCCCGGGCTCCGGCAGCAGCAGCGTCTCTGCTGGGCTTCAGAAG ATGGTGATTGAAAATGACCTCTCTGGTCTGATAGATTTCACCCGGTTACCGTCTCCAACCCCCGAAAACA AGGACTTGTTTTTTGTCACAAGGTCCTCCGGGGTCCAGCCTTCACCTGCCCGCAGCTCAAGCTACTCAGA AGCCAATGAACCTGACCTGCAGATGGCCAATGGCAGCAAGAGCCTGTCCATGGTGGACCTCCAGGACGCC CGCACGCTGGATGGGGAGGCAGGTTCCCCAGTGGGCCCAGACGCCCTACCTGCTGACGGGCAGGTGCCTG CGACTCAGCTGCTGGCTGGGTGGCCAGCCAGGGCAGCCCCAGTGAGCCTGGCAGGATTGGCCACAGTGCG GCGGGCAGTGCCAACACCAACCACACCAGGCACCTCCGAGGGTGCACCAGGACGGCCCCAGTTGTTGGCC CCACTTTCCTTCCAGAATCCTGTGTACCAGATGGCGGCCGGCCTGCCACTGTCACCCCGTGGCCTTGGTG ACTCAGGCTCTGAAGGCCACAGCTCCCTGAGCTCTCACAGCAACAGTGAAGAGCTGGCAGCCGCTGCCAA ACTAGGAAGTTTCAGCACTGCTGCAGAGGAGCTGGCAAGGCGGCCTGGAGAACTGGCACGGAGGCAGATG TCACTGACTGAGAAGGGTGGGCAGCCCACAGTGCCGAGGCAAAATAGTGCCGGTCCCCAGCGGAGGATTG ACCAGCCGCCACCGCCACCACCACCACCGCCTCCTGCTCCCCGGGGCAGGACACCTCCTACCCTGCTGAG CACCCTACAGTACCCACGACCCTCAAGTGGAACCCTGGCATCAGCATCCCCCGACTGGGCTGGCCCTGGC ACCCGGCTGCGGCAACAGTCCTCCTCCTCCAAGGGAGACAGCCCAGAGCTGAAGCCCCGAGCCATGCACA AGCAGGGCCCTTCACCCGTCAGTCCCAATGCCCTGGACCGCACGGCCGCTTGGCTCTTGACCATGAACGC GCAGTTGTTAGAAGACGAGGGTCTGGGCCCAGATCCCCCCCACAGGGATAGGCTAAGGAGTAAGGAGGAA CTCAGCCAAGCAGAAAAGGATCTGGCAGTGCTACAAGACAAGCTACGGATCTCCACCAAGAAGCTGGAGG AGTATGAGACCCTATTCAAGTGCCAGGAGGAGACGACGCAGAAGCTGGTGCTGGAGTATCAGGCTCGGCT GGAAGAAGGTGAGGAGCGGCTGCGGCGGCAGCAGGAAGACAAGGATATCCAGATGAAAGGCATCATCAGC AGGTTGATGTCAGTGGAAGAAGAACTGAAGAAGGATCATGCAGAGATGCAAGCAGCTGTAGATTCCAAAC AGAAGATCATCGATGCCCAGGAAAAGCGCATTGCCTCGCTGGATGCTGCCAATGCCCGCCTCATGAGTGC CCTCACACAGCTGAAAGAGAGGTACAGCATGCAAGCCCGTAACGGCGTCTCCCCCACCAACCCCACCAAA TTGCAGATTACTGAGAACGGCGAGTTCAGAAACAGCAGCAATTGTTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001290639 |
Insert Size | 3198 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
OTI Annotation | Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
Reference Data | |
RefSeq | NM_001290639.1, NP_001277568.1 |
RefSeq Size | 6075 bp |
RefSeq ORF | 3198 bp |
Locus ID | 69601 |
UniProt ID | Q3UHC7 |
Gene Summary | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (6) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 2. The encoded isoform (6) is shorter at the N-terminus, compared to isoform 2. Both variants 6 and 7 encode isoform 6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MR231540 | Dab2ip (myc-DDK-tagged) - Mouse disabled 2 interacting protein (Dab2ip), transcript variant 6 |
CNY 10,640.00 |
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