Cpeb4 (NM_001290678) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	Cpe-bp4; Cpeb-4; mCPEB-4
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC228726 representing NM_001290678 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGGGATTACGGGTTTGGAGTGCTAGTGCAAAGCAATACTGGGAATAAATCTGCTTTTCCAGTCCGAT TCCATCCACATCTGCAGCCTCCACACCATCACCAAAATGCCACCCCCAACCCTGCTGCTTTTATAAATAA TAACACAGCTGCCAATGGCAGCAGTGCTGGGTCAGCCTGGCTCTTTCCTGCCCCGGCTACTCATAACATT CAGGATGAGATCTTGGGGTCAGAAAAAGCAAAAAGTCAACAGCAAGAACAACAAGACCCTTTAGAAAAGC AACAGCTCTCCCCGAGTCCAGGTCAGGAAGCTGGAATACTGCCTGAAACTGAAAAGGCAAAAGCTGAAGA AAATCCAGGGGACAGTTCTTCAGAAAACAGCAACGGAAAAGAAAAACTACGCATTGAATCACCAGTGTTG ACAGGGTTTGATTACCAAGAAGCCACCGGTCTCGGGACTTCCACCCAACCCTTGACATCCAGTGCATCGT CCCTTACTGGTTTCAGTAACTGGTCAGCAGCGATAGCACCTTCTTCCTCCACTATAATCAATGAAGATGC AAGTTTCTTTCACCAGGGAGGGGTCCCTGGCGCTTCAGCTAATAATGGTGCTCTCTTGTTTCAAAATTTT CCCCATCATGTCAGCCCTGGCTTTGGTGGTAGCTTCTCCCCTCAGATCGGGCCTCTCTCCCAGCACCATC CTCATCACCCCCATTTCCAGCACCATCACAGCCAGCATCAGCAGCAGAGGAGGTCTCCTGCCAGTCCCCA CCCCCCACCTTTCACACATAGAAGTGCTGCTTTTAACCAGCTGCCTCATTTGGCGAATAATCTTAACAAA CCTCCTTCTCCATGGAGCAGCTACCAGAGTCCTTCTCCAACCCCCTCTTCTTCCTGGAGCCCAGGAGGTG GCGGCTACGGTGGCTGGGGAGCATCTCAAGGCCGGGATCACCGCAGAGGGCTGAACGGTGGAATAACACC CCTGAACTCAATCTCACCTTTGAAGAAAAATTTCGCAAGCAATCATATTCAGCTCCAGAAGTATGCTCGC CCTAGCTCAGCCTTTGCTCCAAAATCCTGGATGGAAGATAGCTTGAACAGGGCTGACAACATTTTTCCTT TTCCGGAACGCCCCAGGACGTTTGACATGCACTCACTGGAGAGCTCACTCATTGACATAATGAGAGCTGA AAATGATTCCATTAAAGGTCAGTCTTCATTGTTTCCGATGGAAGATGGATTCCTGGATGATGGCCGTGGG GATCAACCTCTTCATAGTGGTCTGGGGTCACCTCACTGCTTCACTCACCAGAATGGGGAGAGAGTGGAAC GATACTCTCGCAAAGTGTTTGTGGGTGGATTGCCTCCTGATATTGATGAAGATGAGATCACAGCTAGTTT CCGTCGCTTTGGCCCTTTGATTGTGGATTGGCCTCATAAGGCAGAGAGCAAATCTTATTTTCCACCAAAA GGCTATGCATTCCTGCTGTTTCAAGATGAAAGTTCTGTTCAGGCTCTCATTGATGCATGTATTGAAGAAG ATGGAAAACTTTACCTGTGTGTATCAAGTCCAACCATCAAGGATAAACCAGTGCAGATCCGGCCCTGGAA TCTCAGTGACAGTGACTTTGTGATGGATGGCTCACAGCCACTTGACCCACGGAAAACAATATTTGTTGGT GGTGTTCCTCGACCATTACGAGCTGTGGAGCTTGCAATGATAATGGATCGGCTGTATGGAGGCGTCTGCT ATGCTGGAATCGATACTGACCCAGAGCTCAAATACCCAAAAGGAGCTGGAAGAGTCGCGTTTTCTAATCA ACAGAGTTACATAGCTGCTATCAGTGCCCGCTTTGTTCAGCTGCAGCATGGAGAGATAGATAAACGGGTG GAGGTTAAGCCATATGTCTTGGATGACCAGCTGTGTGATGAATGTCAAGGGGCCCGTTGTGGGGGGAAAT TTGCTCCATTTTTCTGTGCTAATGTTACCTGTCTGCAGTATTACTGTGAATATTGCTGGGCTGCTATTCA CTCTCGTGCTGGCAGAGAATTCCACAAGCCCCTGGTGAAGGAAGGTGGTGACCGCCCTCGGCATATTTCA TTCCGCTGGAACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001290678
Insert Size	2115 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001290678.1, NP_001277607.1
RefSeq Size	7580 bp
RefSeq ORF	2115 bp
Locus ID	67579
UniProt ID	Q7TN98
Gene Summary	Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3' UTR (PubMed:17024188). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (By similarity). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (PubMed:28092655). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (By similarity). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (By similarity). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (PubMed:24386439).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

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