Micu1 (NM_001291442) Mouse Untagged Clone
CAT#: MC227933
Micu1 (untagged) - Mouse mitochondrial calcium uptake 1 (Micu1), transcript variant 1
CNY 4,660.00
货期*
3周
规格
Product images
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经常一起买 (3)
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | C730016L05Rik; Calc; Cbara1 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC227933 representing NM_001291442
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGTTTCGTCTTAACACCCTTTCTGCGTTGGCAGAACTAGCTGTGGGCTCTCGCTGGTACCATGGGGCAT CACAGCCCACACAGACCAAACGAAGATTGATGCTGGTGGCGTTCCTGGGAGCATCTGCAGTGACTGCAAG TACCGGTCTCCTGTGGAAGAAGGCTCACGCAGAATCTCCACCATGCGTTAACAGCAAGAAGCCTGACACA GAAGATAAAGAGAGAAACAAAGACAGCGGGGAAGTGTCCAGCCGTGAAGGAAGGGCTGCAGATGCTGCGG CAGAGCCTTATCCTGAGGACAAGAAGAAGAAGCGCTCTGGATTCAGAGACAGAAAAGTGATGGAGTATGA GAATCGAATCCGAGCCTACTCCACACCAGACAAAATTTTCCGATATTTTGCCACCTTGAAAGTAATCAAC GAACCTGGTGAAACCGAAGTGTTCATGACTCCGCAGGACTTTGTGCGCTCCATAACGCCCAATGAGAAGC AGCCAGAACACTTGGGCCTGGATCAGTATATAATAAAGCGCTTTGATGGAAAGGAGTTCTGGCAGACCGA GAAAATTGCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAGCATCTTCTACAGCCTTGGAGAGTGTGGG CTCATCTCCTTCTCTGACTACATCTTCCTCACAACAGTCCTCTCCACTCCTCAGAGAAATTTTGAAATTG CTTTCAAGATGTTTGACTTGAATGGAGACGGAGAGGTAGACATGGAGGAGTTTGAGCAGGTTCAGAGCAT CATTCGCTCCCAGACCAGCATGGGCATGCGTCACAGAGACCGTCCAACCACTGGGAACACCCTCAAGTCT GGCTTATGTTCGGCCCTCACGACCTACTTTTTTGGAGCTGATCTCAAAGGGAAACTGACCATCAAAAACT TCCTGGAATTTCAGCGCAAACTTCAGCATGACGTTCTAAAGCTGGAGTTTGAACGCCATGACCCGGTAGA TGGGAGAATCTCTGAGAGGCAGTTCGGGGGCATGCTGCTGGCCTACAGTGGAGTGCAGTCCAAGAAGCTG ACCGCCATGCAGAGACAGCTGAAGAAGCACTTCAAAGATGGGAAGGGCCTGACTTTCCAGGAGGTAGAGA ACTTCTTCACTTTCCTGAAGAACATTAATGACGTGGACACTGCACTAAGCTTTTACCACATGGCTGGAGC ATCTCTTGATAAAGTGACCATGCAGCAAGTGGCCAGGACAGTGGCGAAGGTCGAACTCTCGGACCATGTG TGTGACGTGGTGTTCGCGCTCTTTGACTGTGATGGCAATGGGGAGCTGAGCAACAAGGAGTTCGTTTCCA TCATGAAGCAGCGGCTGATGAGAGGCCTGGAGAAGCCCAAGGACATGGGCTTCACCCGCCTCATGCAGGC CATGTGGAAATGTGCCCAAGAAACTGCCTGGGACTTTGCTCTGCCCAAATAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001291442 |
Insert Size | 1452 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
OTI Annotation | Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001291442.1, NP_001278371.1 |
RefSeq Size | 2376 bp |
RefSeq ORF | 1452 bp |
Locus ID | 216001 |
UniProt ID | Q8VCX5 |
Gene Summary | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (By similarity). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (By similarity). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MR230144 | Micu1 (myc-DDK-tagged) - Mouse mitochondrial calcium uptake 1 (Micu1), transcript variant 1 |
CNY 4,850.00 |
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