Hax1 (NM_001282032) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	HAX-1; Hs1bp1; HSP1BP-1; mHAX-1s; SIG-111; Silg111
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC226218 representing NM_001282032 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAGCGTCTTTGATCTTTTCCGAGGCTTTTTCGGCTTTCCTGGACCTCGGAGCCACAGAGATCCTTTTT TTGGAGGGATGACTCGAGATGATGACGACGATGATGATGATGATGACGAAGCGGAGGAAGACAGAGGCGC GTGGGGTCGAGAGAGCTATGCGTTTGATGGTTCTCAGCCTCCAGAGGAATTCGGTTTCAGCTTCAGCCCC AGGGGAGGGATGCGATTCCACGGCAACTTTGGCTTTGATGATCTATTGGATGATACATGGCCTGTGAGTC CCCATTCTAGAGCCAAAGAGGACAAAGATCTTGACTCCCAGGTTTCCCAGGAAGGTCTGGGTCCACTTCT TCAACCCCAGCCCAAATCGTATTTCAAAAGTATCTCTGTGACCAAGATCACTAAGCCAGATGGGACAGTG GAGGAACGCCGCACTGTGGTAGACAGTGAGGGCCGGAGGGAGACCACAGTGACCCATCAAGAAGCCCATG ACAGTTCCAGAAGTGATCCAGACTCTCAGAGATCTTCAGCTTTGGATGATCCCTTTTCCATTCTGGATTT GCTACTAGGACGTTGGTTTCGGTCCCGATAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001282032
Insert Size	591 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001282032.1, NP_001268961.1
RefSeq Size	923 bp
RefSeq ORF	591 bp
Locus ID	23897
Gene Summary	Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate in-frame splice site and exon in the coding region, but maintains the reading frame compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

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