Sorl1 (NM_011436) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	2900010L19Rik; AI596264; AW261561; gp250; LR11; mSorLA; SorLA
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC225229 representing NM_011436 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGACACGGAGCAGCAGGAGGGAGTCGAGACTCCCTTTCCTATTCGCCCTGGTCGCGCTGCTACCCC GCGGGGCTCTCGGCGGGGGCTGGACGCAGAGATTGCACGGTGGCCCGGCGCCCTTGCCCCAGGACCGGGG CTTCTTCGTGGTGCAGGGCGACCCGCGCGATCTCCGGCTAGGAACGCACGGGGATGCCCCGGGGGCGAGC CCGGCGGCCAGGAAGCCACTCAGGACCCGGCGGAGCGCTGCTCTGCAGCCCCAGCCTATCCAGGTGTATG GACAGGTCAGTCTGAATGACTCCCACAATCAGATGGTGGTGCACTGGGCCGGAGAGAAAAGCAACGTGAT CGTGGCATTAGCCCGAGACAGCCTGGCGTTGGCAAGGCCCAAGAGCAGTGATGTGTATGTGTCTTACGAC TATGGAAAATCATTCAGTAAGATTTCAGAGAAGCTGAACTTTGGCGTGGGCAACAACAGCGAAGCTGTGA TCTCCCAGTTCTACCACAGCCCTGCTGACAACAAGAGGTACATCTTTGTGGATGCTTACGCCCAATACCT CTGGATCACATTTGACTTCTGCAGCACTATCCATGGCTTCTCCATCCCATTCCGGGCGGCTGATCTCCTC CTCCATAGCAAGGCCTCCAACCTCCTCTTGGGCTTTGACAGGTCTCACCCCAACAAGCAGCTATGGAAGT CAGATGATTTTGGCCAGACCTGGATCATGATTCAGGAACACGTGAAGTCCTTCTCTTGGGGAATCGACCC CTATGATCAGCCAAACGCTATCTACATTGAGCGACATGAACCCTTTGGGTTCTCCACAGTGCTCCGCAGT ACAGACTTCTTCCAGTCCCGGGAAAACCAGGAAGTGATCCTGGAGGAAGTGAGAGACTTTCAGCTTCGCG ACAAGTATATGTTTGCTACAAAGGTGGTGCATCTTCCGGGCAGCCAGCAGCAGTCATCTGTCCAGCTCTG GGTCTCCTTTGGCCGGAAGCCTATGAGAGCAGCCCAGTTTGTCACAAAGCATCCTATTAATGAATATTAC ATCGCTGATGCCGCCGAGGACCAGGTGTTCGTGTGTGTTAGCCACAGTAACAACAGCACTAACTTATACA TCTCAGAGGCAGAGGGGCTGAAGTTCTCCCTCTCCTTGGAGAATGTGCTGTATTACAGCCCAGGAGGGGC CGGCAGTGACACTCTGGTGAGGTATTTTGCAAATGAGCCGTTTGCCGACTTTCACCGCGTGGAAGGCTTA CAAGGAGTCTATATTGCCACCCTGATTAATGGTTCTATGAATGAGGAGAACATGAGGTCGGTCATCACCT TTGACAAAGGGGGAACCTGGGAATTTCTTCAGGCCCCAGCCTTCACAGGATATGGAGAGAAAATCAATTG TGAGCTTTCTCAGGGTTGTTCCCTCCACCTGGCCCAGCGCCTCAGTCAACTGCTCAACCTCCAACTTCGG AGGATGCCTATCCTATCCAAGGAGTCAGCCCCCGGTCTCATCATTGCTACCGGCTCTGTGGGAAAGAACT TGGCCAGCAAGACCAATGTGTACATCTCTAGCAGTGCTGGAGCCAGGTGGAGAGAGGCTCTTCCCGGACC TCATTACTATACTTGGGGTGACCATGGAGGCATCATCATGGCGATTGCCCAGGGCATGGAGACCAACGAG CTGAAGTACAGCACCAATGAAGGGGAGACCTGGAAGACGTTCGTCTTCTCGGAGAAGCCTGTGTTTGTGT ATGGGCTTCTCACAGAACCTGGTGAGAAGAGCACCGTCTTCACCATCTTCGGCTCGAACAAGGAGAGTGT CCACAGCTGGCTCATCCTGCAGGTCAATGCCACTGATGCCTTGGGGGTTCCTTGCACAGAAAACGACTAC AAGCTGTGGTCCCCATCTGATGAGCGAGGAAATGAGTGTTTGCTAGGACACAAGACAGTTTTCAAAAGGA GGACCCCTCATGCCACGTGCTTTAATGGGGAAGACTTTGACCGGCCAGTGGTTGTGTCCAACTGCTCCTG CACCCGGGAGGACTACGAATGTGACTTTGGCTTCAAGATGAGCGAAGATCTCTCCTTAGAGGTTTGTGTT CCAGACCCTGAGTTTTCTGGGAAGCCCTACAGCCCTCCTGTGCCTTGTCCTGTGGGTTCTTCATACAGGA GAACGAGAGGCTATCGGAAGATTTCTGGGGATACGTGCAGTGGAGGAGACGTTGAAGCGCGGCTGGAAGG GGAGCTGGTCCCCTGTCCCCTTGCAGAAGAGAATGAGTTCATCCTATACGCCATGCGCAAGTCCATCTAC CGCTACGACTTGGCCTCGGGAGCCACAGAGCAGCTTCCTCTCTCGGGGCTGCGGGCGGCTGTGGCCCTGG ACTTTGACTATGAACGCAACTGCTTGTATTGGTCTGACCTGGCGCTGGACACCATCCAGCGTCTCTGCTT GAACGGGAGCACAGGGCAGGAGGTGATCATCAATTCCGGCCTGGAGACCGTGGAGGCTTTGGCCTTCGAA CCCCTCAGCCAATTACTTTACTGGGTGGATGCCGGCTTTAAAAAGATCGAGGTAGCTAATCCAGATGGTG ACTTCCGACTGACAATCGTCAATTCCTCTGTGCTTGATCGACCCAGGGCTTTAGTCCTTGTACCCCAAGA AGGGGTGATGTTCTGGACTGACTGGGGGGACCTGAAGCCTGGGATTTACCGGAGCTACATGGACGGCTCT GCTGCCTACCGCCTTGTGTCAGAGGACGTGAAGTGGCCCAATGGCATCTCTGTGGACAGCCAGTGGATCT ACTGGACGGATGCTTACCTGGACTGTATCGAGCGCATCACTTTCAGTGGCCAGCAGCGTTCAGTCATCCT TGACAGCCTCCCACACCCCTATGCCATCGCTGTCTTTAAGAATGAGATCTACTGGGATGACTGGTCACAG CTCAGCATCTTCAGAGCTTCGAAGCACAGCAGATCCCAGGTGGAGATTCTAGCAAGCCAGCTCACGGGCC TCATGGACATGAAGGTTTTCTACAAGGGAAAGAATGCTGGAAGCAACGCTTGTGTCCCTCAGCCCTGCAG TCTACTGTGCCTCCCTAAGGCCAACAACAGCAAAAGCTGCAGGTGTCCAGAAGGTGTGGCCAGCAGTGTC CTCCCCTCTGGGGACCTGATGTGTGACTGCCCTCAGGGCTATCAAAGGAAGAACAACACCTGTGTCAAAG AAGAGAACACCTGTCTCCGAAACCAGTATCGCTGCAGCAACGGCAACTGTATCAACAGCATTTGGTGGTG TGATTTCGACAATGACTGTGGAGACATGAGTGACGAGAGAAATTGCCCCACGACGGTCTGTGATGCAGAC ACTCAGTTCCGGTGCCAGGAGTCGGGGACTTGCATTCCACTCTCCTATAAGTGTGACCTTGAAGATGACT GTGGAGATAACAGTGATGAGAGTCACTGTGAGATGCACCAGTGTCGTAGCGACGAGTTCAACTGCAGCTC TGGGATGTGCATCCGGTCCTCCTGGGTGTGCGATGGAGACAACGACTGTAGGGACTGGTCTGATGAAGCC AACTGTACTGCCATCTATCATACCTGTGAGGCCTCCAACTTCCAGTGCCACAATGGCCACTGCATCCCCC AGCGATGGGCATGTGACGGTGATGCGGATTGCCAGGATGGCTCTGACGAAGATCCCGTCAGCTGTGAGAA AAAGTGCAATGGATTCCACTGCCCAAACGGCACGTGCATCCCGTCCAGCAAGCATTGTGATGGGCTGAGG GACTGCCCCGACGGCTCCGATGAGCAGCACTGTGAGCCCTTCTGCACGCGCTTCATGGACTTCGTGTGTA AGAACCGTCAGCAGTGTCTGTTCCACTCCATGGTGTGTGACGGGATCGTCCAGTGCCGAGATGGCTCTGA TGAGGATGCGGCCTTCGCTGGATGCTCGCAAGACCCCGAGTTCCACAAGGAGTGCGATGAGTTCGGCTTC CAGTGTCAGAACGGAGTGTGCATCAGCTTGATTTGGAAATGCGATGGGATGGATGACTGCGGGGACTACT CTGACGAGGCCAACTGTGAAAACCCCACGGAAGCCCCAAACTGTTCCCGTTACTTTCAGTTCCACTGTGA GAATGGCCACTGCATCCCCAACAGGTGGAAATGTGACAGAGAGAACGACTGTGGGGACTGGTCTGATGAG AAGGATTGTGGAGATTCACATGTTCTACCCTCCCCGACCCCCGGGCCCTCCACGTGTCTGCCCAATTACT TCCACTGCAGCAGCGGGGCCTGTGTGATGGGCACCTGGGTGTGCGACGGCTACAGGGACTGTGCAGATGG CTCTGATGAGGAGGCCTGCCCCTCTCTAGCAAACTCCACTGCCGCCTCCACTCCCACCCAGTTCGGGCAG TGCGACCGATTTGAGTTCGAGTGTCACCAACCAAAGAAATGTATCCCCAACTGGAAGCGCTGTGACGGCC ACCAAGATTGCCAAGACGGCCAGGATGAAGCCAACTGCCCCACTCACAGCACCTTGACCTGTACGAGCAG GGAGTTCAAGTGTGAGGACGGCGAGGCATGCATCGTGCTCTCGGAGCGCTGTGATGGCTTCCTGGATTGC TCTGATGAGAGCGATGAGAAGGCCTGCAGCGATGAGTTAACTGTATACAAAGTGCAGAATCTCCAGTGGA CAGCTGATTTCTCCGGAGATGTGACTTTGACCTGGATGCGGCCAAAGAAAATGCCATCTGCTTCTTGTGT ATACAATGTCTACTACAGGGTGGTTGGAGAGAGCATATGGAAGACCCTGGAAACCCACAGCAATAAAACA AGCACTGTGCTCAAGGTCCTGAAGCCAGACACCACGTACCAGGTTAAGGTCCAGGTGCACTGCCTCAACA AGGTGCACAACACCAATGACTTTGTGACCCTCAGGACTCCAGAAGGGTTGCCAGATGCCCCTCGGAATCT CCAGCTCTCCCTGAACAGTGAAGAGGAAGGTGTGATTCTCGGGCACTGGGCTCCTCCCGTCCACACCCAT GGCCTCATCCGTGAGTACATTGTGGAATACAGCAGGAGTGGGTCCAAGATGTGGGCCTCCCAGAGAGCTG CTAGCAACTCTACAGAAATAAAGAACTTACTGCTCAATGCCCTCTACACTGTCAGAGTGGCTGCGGTGAC TAGTCGTGGGATAGGAAACTGGAGCGATTCTAAGTCCATCACCACCATAAAAGGAAAAGTGATCCAAGCA CCAAATATCCACATTGACAGCTACGATGAAAATTCTCTGAGCTTTACCCTGACCATGGATGGTGACATCA AGGTCAATGGCTACGTGGTGAACCTTTTCTGGTCATTTGATGCCCACAAACAAGAAAAGAAAACCCTGAG CTTCCGCGGAGGGAGTGCACTGTCACACAGAGTTAGCAACCTGACAGCTCATACATCCTATGAGATTTCT GCCTGGGCCAAGACAGACTTGGGAGATAGCCCACTGGCCTTTGAGCACATCTTGACCAGAGGCAGCAGTC CACCAGCTCCTAGTCTCAAAGCCAAGGCCATCAATCAGACTGCAGTGGAGTGCATCTGGACTGGCCCCAA GAATGTGGTGTATGGTATTTTCTATGCCACATCCTTCCTTGACCTCTACCGAAACCCTAAGAGCGTAACT ACTTCGCTCCACAATAAGACAGTCATCGTCAGCAAGGATGAGCAGTATCTGTTTCTGGTCCGGGTGTTGA TCCCTTACCAAGGGCCGTCTTCTGACTACGTTGTAGTGAAGATGATCCCAGACAGCAGGCTCCCGCCTCG GCATCTGCACGCGGTCCACATAGGCAAAACCTCAGCACTCATCAAATGGGAATCGCCCTATGACTCTCCT GACCAGGACTTGTTCTACGCCATTGCAGTGAAAGATCTGATCAGGAAGACGGACAGAAGCTACAAAGTCA GATCCCGCAACAGTACTGTGGAGTACAGCCTAAGCAAGCTGGAACCTGGAGGGAAATACCACATCATTGT CCAGCTGGGAAACATGAGCAAGGATTCCAGCATAAAAATCACCACAGTTTCGTTATCAGCACCTGATGCC TTAAAAATCATAACGGAAAACGACCACGTTCTCCTCTTTTGGAAAAGCCTAGCACTGAAGGAAAAGCAGT TCAATGAAACCAGGGGCTATGAGATCCACATGTCTGACAGCGCTGTGAATCTCACCGCTTACCTCGGGAA TACTACGGACAATTTCTTTAAAGTGTCCAACCTGAAGATGGGTCATAACTACACTTTCACGGTCCAAGCG CGGTGTCTCTTTGGTAGCCAGATCTGTGGGGAGCCCGCCGTGCTGCTGTACGATGAACTGAGCTCAGGTG CAGATGCGGCAGTGATCCAGGCTGCCCGGTCTACTGATGTTGCAGCTGTGGTGGTTCCCATCCTGTTCCT GATCCTGCTGAGCCTGGGTGTCGGCTTCGCCATCCTCTACACGAAGCACCGTCGCTTACAAAGCAGCTTC AGCGCTTTCGCCAACAGCCACTACAGCTCCAGGCTGGGCTCGGCCATCTTCTCCTCAGGGGATGACCTAG GAGAGGACGATGAAGATGCTCCCATGATTACTGGATTCTCAGACGATGTCCCCATGGTGATAGCGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_011436
Insert Size	6648 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_011436.3, NP_035566.2
RefSeq Size	6938 bp
RefSeq ORF	6648 bp
Locus ID	20660
UniProt ID	O88307
Gene Summary	Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. Involved in APP trafficking to and from the Golgi apparatus (By similarity). It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta (By similarity). Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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