Dennd3 (NM_001081066) Mouse Untagged Clone
CAT#: MC224136
Dennd3 (untagged) - Mouse DENN/MADD domain containing 3 (Dennd3), (10ug)
CNY 16,440.00
Product images
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | AI447457; E030003N15Rik |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC224136 representing NM_001081066
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGGAGCCCGCGGCGCGACACCTGTCGCTGCCCTCGGGGCTGCTGGAGTTGTGCGCGCTGCTGGGCG CCTCTCAAGACAGCCTCCGCGGCCTGGAGCAGATTGCCCAGAAACGAGGAGTGAAGAGCGCCTCTTCCCT TGTCCCCGAAGTTCTGTCTGTTTTCGTGCCTCCTTTCACCACAAAAGAGGATGGCCAGGTACCGGGGGCC AGCTGTGCTCTTGGCAAAGGCAGGAGGCGTTCCTTCCGGAAGAAGCGAGAGAAGCCCAGGATGGAGCCCT GGAAGAGCCACCCTGGAGACTCCAAGGGGCCCGATTCTGAAGATGTCACCATCCCAGGAGGTGTGGACCT CCTTGCCCTGCCTCAGCTCTGCTTCCCAGGGTGTGTGTGTGTGGCTTCGGAACCCAAAGAGGACTACATC CATTTCCTGGTGCTCACGGATGTCTGTGGAAATAGAACCTATGGTGTGGTCGCCCAGTACTATCGACCCC TGCATGATGAATATTGTTTCTACAATGGCAAGAGCCACTGGGAGCCCAGCGTGATCTCAGCTAGGTGCTT TGTGCCTTTTGCAGTGTGTGTGGTGTCCCGATTCCCCTACTATAACTCCCTCAAGGACTGCCTCTCCTGT TTATTGACTCATCTGAAGCTCTGTAAAGATTTTGAAGTTGACAATCACATAAAGGATTTCGCTGCACGAC TGTCCTTAATACCTAGTCCACCGCCTGGGCCGCTCCACTTGATATTTAACATGAAGCCGCTGCAGGTCGT CTTTCCCTCTCGAGCGGACCCCGAGAGCCCCATCGTCGACTTGGACCTTCACCTGCCCCTGCTGTGCTTC CGGCCTGAGAAAGTGTTGCAGATCCTGACCTGTATCTTGACGGAACAGCGCATCGTGTTCTTCTCCTCAG ACTGGGCCCTGCTGACGCTCATGGCCGAGTGCTTTGTGGCCTACCTCCACCCGCTGCAGTGGCAGCACAC GTTTGTGCCCATCCTGTCGGGTCAGATGCTGGACTTCGTCATGGCTCCCACGTCTTTCCTCATGGGCTGT CATCTCGACCACTTTGAAGAAGTCAGAAAGGAAGCTGATGGTTTGGTCCTGATTGACATTGACCACGGGA GTGTCACCTGCTCCAAGTCTTCTGACGACAACATAGACATTCCTGATGTCCCCCTTCTGCTGGCACAGAC CTTCATTCAGAGAGTCCAGAGTCTCCAGCTGCACCCGGATTTGCACCTTGCCCACCTGAGTGCCAGCACA GACTTGAACGAGGGCCGAGCCCGCCGCCGAGCCTGGCAGCAGACTCTCAACTGCAAGATTCAGCACATCA CTCTACAGCTGCTCGTTGGCATCTTCAGGGAAGTGAAGAATCACTTGAATTATGAACACCGCGTCTTCAA CAGCGAGGAGTTTCTCAAGACAAGAGCGGCAGGGGACCAGCAGTTTTATAAGCAGGTTTTGGACACCTAC ATGTTCCACTCCTTTCTGAAGGCGCGGCTCAACGGCAGGATGGACGCCTTTGCTCGGATGGACCTCGACA CTCAGTCTGAGGAGGACAGGATAGACAGGATGCTGATAAGTCCAAGGAGACCTACTGTGGAGAAGATGGC CTCCAGGAAGGCCTCACCCCTGCACATCACCCACAGACGCATGGTGGTCAGCATGCCCAACCTGCAGGAC ATCTCCCTGCCCGAGCTGCCTCCCAGGAACTCATCGCTTCGGATAATGGACACCTCAAACTGCAGAAGCA GCAGTCCAGTTCTCAAAGTGACCCCTAAGTCAACATATATGTTCAAGATCCCTGATATCCACTTCCCACT GGAGAGCCAGTGTGTTCAGGCATACTATACAGACTTCGTCACTCTCCTGAGCAAGGCCATGGCGCTGTTG GGTCCTGGCGACTCTCTGCTCCTAGCCAGGTACTTCTACCTGCGTGGTCTTCTCCATCTGATGCAGGGAC AACTGCTGAGTGCCCTCTTGGATTTCCAGAACCTGTATAAGACCGACATAGGGATCTTCCCGGCTGATCT GGTCAAGAGAACGGTGGAATCCATGTCGGCCTCTGAGCGGGCCCAGGCCGAGCGGACGCCTGAGCTCAGG CGGCTCATCACAGAGGTCTTTGATAAGCACGGCGAGGCCCCCAAGGCAGATGACGCCGTGAAGAACTTCG AACTGCCCAAGAAGCACATGCAACTCAATGACTTTGTGAAGCGAGTCCAGGAGTCGGGGATCGTGAAGGA CGCCGTCATTATCCACCGTCTGTTTGATGCACTGACCTTCGGACACGAGAAGCAGATTGACCCGGAGACC TTCCGAGACTTTTACACCTGCTGGAAGGAGACTGAGGCAGAGGCACAGGAGGTCAGCCTGCCCGCACTGC TCATGGAGCACCTGGATAAGAACGAGTGCGTCTACAAGCTGTCGAGCTCTGTGAAGACCAACCGTGGAGT GGGCAAGATCGCCATGACCCAGAAGCGCCTGTTCTTGCTCACCGAGGGGCGGCCCGGCTATGTGGAGATT GCCACCTTCAGGAACATAGAGGAAGTCAAAAATAGCACCGTGGCATTTCTCCTCCTGAGGATACCCACCT TAAAGATCAAGACGGTGGCCAAGAAGGAAGTCTTCGAGGCCAACCTCAAGTCGGAGTGTGACCTCTGGCA CCTCATGGTGAAGGAGATGTGGGCCGGAAAGCAGCTGGCAGATGACCACAAGGACCCACAGTACGTCCAG CAGGCACTGACCAATGTCCTGCTCATGGATGCCGTGGTTGGCACGCTGCAGTCACCTAGTGCCATTCATG CTGCCTCCAAGCTGGCCTACTTTGACAACATGAAGAAGAAGTCACCCATGGCGGTCCCAAAGACAACCTC GGAGACCCTAAAACACAAGATTAACCCTTCAGCCGGAGAGACCGCTCCCCAAGCCATTGAAGTCCTGCTG TATACTCCAGGGCGCCTGGATCCTGCAGAGAAGGTGGAAGATGCCCACCCCAAGCTGTGGTGTGCCCTGA ACGAAGGCAAAGTGGTCGTGTTTGATGCCTCCTCTTGGACCGTCCACCAGCATTGCTTTAAAGTGGGTTC CTCGAAAGTGAACTGTATGGTGATGGCGGAGCACAACCAGGTGTGGGTGGGCTCCGAGGACTCTGTCATC TACATCATCAATGTCCACAGCATGTCCTGCAACAAACAGCTCACGGATCACCGTTCTCCAGTCACTGGCT TGGCCGTGCACAATGGAAAGAAGCCCAGTGAGATCTACTCCTGTAGTCTGGATGGGACGGTCATCGCGTG GAATGTCAGCACACTGCGAGTGATCAGCCGGTTCCAGCTGTCATACGGTGACCTCCTGTCCATCAGCCTG CACAACGACCGCATATGGTGTTGTACAGTCCACAAGATCTTGGTGGTGACCCCGCAGGGCTTTGTTCGTC AAGAGCTGAAGCATCCGAAAGATGCCTCCTTCCTGGCCTTCCAACTTCTGCCTGAGGAGCAGCAGCTGTG GGCGGCCTCTACGGGGGTCAGTGAGCTGTATATGTGGAGCCTGAAGGACCTGGACCAGCCTCCTCAGAAG ACTTACTTACAAGACTGCTCCGAGGTCACCTGTATGATCCGGGTGAAGAGGCAGATCTGGGTGGGCGGCA GGGGGCTGTCTCAGGGAAAAACCAGAGGGAAGATCTACGTGATGGACGTGGAGAAGGTGACGGTGGAAAA GGAGCTGGTGGCACACTTGGACACCGTGAGGACCCTGTGTTCTGCTGAGGACCGCTACGTACTGAGCGGA GCGGGCCAGGAGGAGGGAAAGATCGCCATCTGGAAGGTGGAGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001081066 |
Insert Size | 3825 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
Reference Data | |
RefSeq | NM_001081066.1, NP_001074535.1 |
RefSeq Size | 5299 bp |
RefSeq ORF | 3825 bp |
Locus ID | 105841 |
UniProt ID | A2RT67 |
Gene Summary | Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the protein coding transcript. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MG224998 | Dennd3 (tGFP-tagged) - Mouse DENN/MADD domain containing 3 (Dennd3), (10ug) |
CNY 12,350.00 |
|
MR224998 | Dennd3 (Myc-DDK-tagged) - Mouse DENN/MADD domain containing 3 (Dennd3) |
CNY 8,880.00 |
|
MR224998L3 | Lenti ORF clone of Dennd3 (Myc-DDK-tagged) - Mouse DENN/MADD domain containing 3 (Dennd3) |
CNY 13,110.00 |
|
MR224998L4 | Lenti ORF clone of Dennd3 (mGFP-tagged) - Mouse DENN/MADD domain containing 3 (Dennd3) |
CNY 13,110.00 |