Larp1 (NM_028451) Mouse Untagged Clone
CAT#: MC223454
Larp1 (untagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1), (10ug)
CNY 13,780.00
Product images
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | 1810024J12Rik; 3110040D16Rik; Larp; mKIAA0731 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC223454 representing NM_028451
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCCACTCAAGTGGAGCCGCTGCTGCCGGCGGGCGCCCCGCTGCTGCAGGCCGAGGAGCACGGCCTGG CGAGGAAGAAGCCGGCGCCCGACGCCCAGGCCGAGTCGGGCCCGGGTGACGGCGGCGGAGAGCCCGACGG CGGCGTCCGCAGGCCGCGGCCCGCCTGCGCCAGGCCTGGCCGCGACGGCGCGGAGCGCGAGAGCCCGCGG CCACCCGCAGCTGCGGAAGCCCCAGCGGGGAGCGACGGCGAGGACGGCGGCCGGCGTGACTTCGTGGAGG CACCGCCGCCCAAGGTGAACCCGTGGACGAAGCACGCGCCGCCGCCGGCCGCGGTGAACGGACAGCCGCC TCCAGAACCTTCTGCTCCAGCCAAGGTGGTGAGGGCAGCTGCTCCTAAACCGCGTAAGGGCAGCAAGGTT GGTGATTTTGGAGATGCAGTCAACTGGCCTACACCTGGAGAGATAGCCCACAAAAGTGTGCAGCCACAGT CCCACAAGCCTCAGCCTGCTCGTAAGTTGCCACCTAAGAAGGACATGAAGGAGCAAGAGAAAGGAGATGG AAGTGATAGTAAGGAGAGCCCAAAAACAAAGTCGGATGAATCGGGGGAGGAAAAGAATGGGGATGAGGAC TGCCAGCGAGGCGGGCAGAAGAAGAAAGGGAGCAAACACAAGTGGGTTCCATTGCAAATAGACATGAAGC CCGAAGTACCCAGAGAGAAATTGGCCTCCCGTCCCACTCGCCCACAGGAACCAAGACATACACCCGCTGT CCGTGGGGAGATGAAAGGATCTGAACCTGCCACCTACATGCCTGTATCTGTGGCCCCACCCACCCCAGCC TGGCAACCAGAGACCAAAGTGGAGCCTGCCTGGCACGACCAGGATGAGACATCGAGTGTGAAGAGTGATG GGGCTGGTGGGGCTCGGGCTTCCTTCCGTGGCCGTGGACGGGGGCGTGGTCGTGGACGGGGCCGTGGACG GGGTGGCACTCGAACCCACTTTGACTACCAGTTTGGCTACCGAAAGTTTGATGGTACAGAGGGGCCCCGC ACCCACAAGTATATGAACAACATCACTTACTACTTTGACAATGTCAGCAGCAATGAGATTTACAGTATGG ACCAGGAGCTGCTCAAGGATTATATCAAACGCCAGATTGAATATTACTTCAGCGTGGACAATTTAGAGCG AGACTTCTTCCTGAGACGGAAAATGGATGCTGATGGCTTCCTTCCCATCACCCTTATTGCTTCCTTTCAC CGTGTACAGGCCCTAACCACTGACATTTCACTCATCTTTGCGGCTCTAAAGGACAGCAAGGTGGTAGAGA TGGTTGAGGAGAAAGTCCGCAGGAGGGAAGAACCTGAAAAGTGGCCACTGCCTGGACCCCCAATAGTGGA TTATTCACAAACTGATTTTTCTCAGCTTCTCAACTGCCCAGAGTTTGTTCCCCGCCAGCACTACCAGAAA GAGACAGAGTCGGCACCTGGCTCTCCCCGTGCAGTCACCCCAGTGCCAACAAAAACAGAGGAGGTCAGCA ACCTGAAGACCCTTCCCAAGGGCCTGTCTGCCAGCCTCCCAGATCTGGATTCTGAGAGCTGGATTGAAGT GAAGAAAAGGCCTCGACCCTCACCAGCACGCCCCAAGAAGCCAGAGGAGCCCAGGTTCTCCCACCCAACT GCTCTGCCTCAGCAGCTTCCCTCCCAGCAGCTGATGTCTAAGGATCAGGATGAGCAAGAAGAACTAGACT TTCTGTTTGACGAGGAGATGGAGCAGATGGATGGGCGGAAGAATACCTTCACTGCCTGGTCTGAAGAGGA CTCTGACTATGAAATTGATGACCGGGATGTCAATAAGATCCTCATCGTCACTCAAACACCACCTTACATG CGTCGCCACCCTGGAGGAGACCGTACAGGCAACCACACTTCGCGTGCCAAGATGAGTGCTGAACTGGCCA AGGTCATTAATGATGGACTCTTCTACTATGAACAAGACCTGTGGACTGAGAAGTTTGAGCCTGAGTATTC ACAGATCAAGCAAGAAGTGGAAAACTTCAAGAAAGTGAATATGATTAGTCGGGAACAGTTTGACACTCTG ACCCCTGAGCCCCCTGTGGATCCTAACCAGGAGGTTCCTCCTGGGCCACCTCGGTTCCAACAAGTTCCTA CTGATGCCCTGGCCAACAAGCTGTTTGGTGCTCCCGAGCCATCTACCATTGCCCGTTCTCTACCAACCAC TGTCCCAGAGTCTCCAAACTACCGAAATGCCAGGACTCCCCGCACACCCCGGACCCCCCAGCTCAAAGAC TCTAGTCAGACACCACGGTTTTACCCTGTGGTGAAAGAAGGACGGACCCTAGATGCCAAGATGCCTCGAA AAAGAAAGACAAGGCACAGCTCGAACCCCCCCTTGGAAAGTCATGTGGGCTGGGTGATGGATTCTCGGGA GCACAGGCCCAGGACTGCTTCTATTAGCTCCAGTCCTTCAGAGGGAACACCTGCAGTCGGCAGCTATGGC TGTACCCCTCAGTCACTGCCCAAGTTCCAGCATCCTTCCCATGAGCTGCTCAAGGAAAATGGCTTCACAC AACACGTCTACCACAAGTATCGGAGGCGCTGCCTTAATGAGCGGAAGCGCTTGGGCATTGGCCAGTCTCA GGAGATGAACACCCTCTTCCGCTTTTGGTCCTTCTTCCTCCGAGATCACTTCAATAAAAAGATGTATGAA GAGTTCAAGCAGCTCGCACTGGAGGATGCCAAAGAAGGCTACAGGTACGGTTTGGAGTGCCTTTTTCGAT ACTACAGTTATGGTCTAGAGAAAAAGTTCCGGCTGGACATATTCAAGGATTTCCAGGAGGAGACAGTGAA GGACTATGAGGCTGGCCAGCTCTATGGATTGGAGAAGTTCTGGGCCTTCTTGAAATACTCCAAAGCCAAA AATTTGGACATTGACCCCAAACTGCAAGAATACCTCGGCAAATTCCGCCGCTTAGAAGACTTCCGAGTGG ACCCCCCCATGGGCGAGGAAGGCAACCACAAGCGACACCCAGTGGTAGCAGGAGGCAGCGGAGAGGGCAG GAAGCGGTGCCCTTCCCAGTCTTCCAGCAGGCCTGCCACTGGGATCAGCCAACCCCCTACGACACCTACT GGCCAGGCCACTCGAGAAGATGCCAAATGGACAAGCCAGCACTCGGACACACTGACTTTGCGAAAGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_028451 |
Insert Size | 3219 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
Reference Data | |
RefSeq | NM_028451.1, NP_082727.1 |
RefSeq Size | 6617 bp |
RefSeq ORF | 3219 bp |
Locus ID | 73158 |
UniProt ID | Q6ZQ58 |
Gene Summary | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.[UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MG224022 | Larp1 (tGFP-tagged) - Mouse La ribonucleoprotein domain family member 1 (Larp1), (10ug). Note: ORF is codon optimized |
CNY 9,220.00 |
|
MR224022 | Larp1 (Myc-DDK-tagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1). Note: ORF is codon optimized |
CNY 7,464.00 |
|
MR224022L3 | Lenti ORF clone of Larp1 (Myc-DDK-tagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1). Note: ORF is codon optimized |
CNY 10,260.00 |
|
MR224022L4 | Lenti ORF clone of Larp1 (mGFP-tagged) - Mouse La ribonucleoprotein domain family, member 1 (Larp1). Note: ORF is codon optimized |
CNY 10,260.00 |