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Ptprn2 (NM_011215) Mouse Untagged Clone
CAT＃: MC223149
Ptprn2 (untagged) - Mouse protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2), (10ug)
CNY 12,920.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 4930425H11Rik; IA2beta; mKIAA0387; phogrin; Phol; PTP-NP |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC223149 representing NM_011215
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGGCCGCCGCTCCCGCTTTTGCTGCTGCTGCTGCTACCGCCGCCGCTGCCTCGCGCTCTGCCCGCCC CCGCGTCTGCCCGCGGCCGGCAGCTCCCGGGGCGCCTGGGATGCTTGTTTGAGGATGGCTTGTGTGGATC ACTGGAGACCTGTGTGAACGATGGTGTGTTTGGAAGATGTCAAAAGGTTCCGGTGATGGACACTTACCGA TATGAGGTACCACCAGGAGCCCTGCTGCACCTGAAGGTCACCTTACAGAAGCTCTCCCGTACAGGTTTCA CGTGGCAAGATGACTATACCCAGCGTGTGATTGCCCAGGAGCTTGCAAACCTCCCCAAGGCCTACCTATG GCATGGGGAAGCGTCCGGCCCAGCCAGGTCCTTACAACAGAATGCTGACAATGAAAAATGGTTCAGTCTG GAGAGGGAGGTGGCCCTGGCCAAGACCCTTCGGCGCTATCTGCCCTACCTGGAGCTTCTGTCCCAGACCC CAACAGCAAATGCACACTCTAGGATAGACCATGAGACTCGTCCAGCCAAGGGTGAAGACTCTTCCCCTGA GAACATCCTGACCTACGTGGCCCACACATCAGCACTGACCTATCCTCCTGCAACCCGGGCCAAGTATCCT GATAACCTTCTGCGGCCCTTTAGCCGGCTCCAGCCAGATGAGCTCAGCCCCAAGGTAGACGGTGACATAG ACAAACAGAAGCTGATTGCAGCACTGGGCGCCTACACTGCTCAGAGGCTTCCTGGAGAAAATGACCCAGA GCCACGGTACCTTGTACATGGTTCCGCGAGAGCACCAAGGCCATTCTCAGCAACTGCTTTGTCTCAGAGA TGGCCTCCACCTCCTGGAGACGCCAAAGACTCCCCGAGTATGGATGATGACACACTCCTGCAGAGTCTCC TGAAGGATTTGCAGCAGAACTCTGAAGTGGACCGCCTGGGCCCCCTGAAGGAGGAGAAAGCAGACTCAGT TGCTGGAGCCATACAAAGTGATCCTGCAGAGGGAAGCCAAGAAAGCCACGGGAGAGGGGCTGAAGGACAG CCAAGAGAGCAGACAGATGCCCCAGAGACAATGCTTCAAGATCACAGACTATCAGAGGTGGATGACCCAG TGTACAAGGAGGTCAACCGTCTGAGCTTCCAGCTTGGGGACCTCTTGAAGGACTATGGGTCTCCTCTCTT ACCTGAAGGTCCCCTTCTAGAAAAATCCTCCAGAGAAGAGATTAAGAAATCAGAGCAGCCAGAGGAGGTC TTGTCTTCAGAAGAGGAGACTGCTGGGGTGGAGCATGTGAGGAGCCGGACTTACTCCAAAGACCTATTTG AAAGGAAACCAAACTCAGAGCCCCAGCCCAGGAGGCTTGAGGATCAGTTCCAAAACCGAGCTCCAGAGTT GTGGGAGGATGAAGAAAGCCTCAAATTGGCAGCACAGGGACCCCCTAGTGGAGGCCTACAGCTGGAAGTG CAGCCTTCTGAGGAACAGCAGGGATACATCCTCACAGGAAACAACCCTCTAAGTCCAGAGAAGGGGAAGC AGCTGATGGACCAAGTTGCCCACATCCTCCGGGTACCTTCCAGCTTCTTTGCAGATATCAAAGTTTTGGG ACCAGCAGTGACCTTCAAAGTAAGTGCCAACATCCAAAACATGACAACTGCCGATGTCATCAAGGCTGCA GCTGACAACAAAGACCAGCTGGAGAAGGCAACTGGACTGACAATCCTTCAAAGTGGAATCAGGCCGAAGG GAAAGCTCAAACTCCTGCCGCATCAGGAAGAGCAAGAGGACTCTACCAAGTTCATTTTGCTCACCTTCCT CTCCATTGCCTGCATCCTGGGGGTTCTCCTGGCTTCCAGCCTTGCCTACTGCCTCCGCCACAACTCACAC TACAAGCTGAAGGACAAGTTGTCTGGACTAGGCGCTGACCCCAGTGCAGATGCCACTGAAGCCTACCAGG AGCTATGCCGCCAGCGTATGGCTATTCGTCCACAGGACCGCTCTGAGGGACCACATACATCACGCATCAA CAGCGTCTCATCCCAGTTCAGCGATGGGCCGATGCCTAGTCCTTCGGCTCGGAGCAGCACTTCATCCTGG TCTGAGGAGCCTGTCCAGTCCAACATGGACATCTCTACTGGCCACATGATCCTGGCCTACATGGAAGACC ATCTGAAGAACAAGAACCGCCTGGAGAAGGAGTGGGAAGCACTGTGCGCCTACCAAGCAGAGCCCAACAG CTCACTTGTGGCCCAGAGAGAGGAGAATGCACCCAAGAACCGTTCCCTGGCTGTGCTGACCTATGACCAC TCCAGGATCCTGTTGAAGTCTCAAAACAGCCATGGCAGTTCCGACTACATCAATGCCAGCCCCATTATGG ACCATGACCCACGAAACCCCGCATACATTGCCACCCAAGGCCCACTTCCCGCCACGGTGGCCGACTTCTG GCAGATGGTGTGGGAAAGCGGCTGTGCAGTCATTGTCATGCTGACACCCCTCTCCGAGAACGGCGTCCGG CAGTGCCATCACTACTGGCCCGATGAAGGCTCCAACCTCTACCATGTCTACGAGGTCAATCTAGTCTCTG AGCACATATGGTGCCAGGATTTCCTGGTGAGAAGCTTTTACCTGAAGAACCTGCAGACCAACGAGACTCG CACGGTGACCCAGTTCCACTTCCTGAGTTGGTATGACCAGGGAGTCCCTTCCTCCACGAGGTCACTCCTG GATTTCCGCAGAAAAGTGAACAAATGCTACCGAGGCCGCTCTTGTCCGATCATTGTCCATTGCAGTGACG GCGCCGGCAGGAGTGGAACCTACGTCCTGATTGACATGGTTCTCAATAAGATGGCCAAAGGTGCTAAAGA GATTGATATCGCAGCGACCCTGGAGCACTTGAGGGACCAGAGACCAGGCATGGTCCAGACAAAGGAGCAG TTTGAGTTTGCGCTGACAGCTGTGGCTGAGGAGGTGAATGCCATCCTGAAGGCCCTTCCCCAGTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_011215 |
| Insert Size | 3006 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_011215.2, NP_035345.2 |
| RefSeq Size | 4688 bp |
| RefSeq ORF | 3006 bp |
| Locus ID | 19276 |
| UniProt ID | P80560 |
| Gene Summary | Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity).[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG215745 | Ptprn2 (tGFP-tagged) - Mouse protein tyrosine phosphatase receptor type N polypeptide 2 (Ptprn2), (10ug) |
CNY 9,220.00 |
|
| MR215745 | Ptprn2 (Myc-DDK-tagged) - Mouse protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2) |
CNY 6,976.00 |
|
| MR215745L3 | Lenti ORF clone of Ptprn2 (Myc-DDK-tagged) - Mouse protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2) |
CNY 10,260.00 |
|
| MR215745L4 | Lenti ORF clone of Ptprn2 (mGFP-tagged) - Mouse protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2) |
CNY 10,260.00 |
