Exosc10 (NM_016699) Mouse Untagged Clone

CAT#: MC222420

Exosc10 (untagged) - Mouse exosome component 10 (Exosc10), (10ug)



  "NM_016699" in other vectors (4)

CNY 11,500.00


货期*
5周

规格
    • 10 ug

Product images

经常一起买 (2)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2; RRP6
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC222420 representing NM_016699
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCGCCTCCCAGTCCCCGGGAGCATCAGTCCGCGCCGGCGACCAGTGCGACCAAGCCTGACGCGGAGA
TGGTACTGCCTGGCTTCCCCGATGCAGACAGCTTCGTAAAGTTTGCACTTGGGTCGGTAGTGGCAGTTAC
CAAGGCATCCGGGGGCCTGCCACAGTTCGGTGACGAGTATGATTTTTACAGAAGTTTCCCTGCCTTCCAG
GCATTCTGTGAGACACAAGGAGACAGGTTACTGCAGTGCATGAGTCGGGTAATGCAGTACCATGGCTGTC
GCAGCAACATCAAAGACCGAAGTAAAGTGACTGAATTGGAGGACAAGTTTGATTTATTAGTCGATACCAA
TGACGTGATATTGGAGAGAGTGGGCATGTTACTGGATGAAGCCTCCGGTGTGAACAAGCATCAGCAGCCT
GTCCTTCCTGCAGGGCTGCAGGTCCCCAAAACAATAGTATCCAGCTGGAATCGGAAGGCAGGAGAGTATG
GCAAAAAGGCAAAATCGGAGACTTTCCGACTGCTGCATGCAAAAAACATCGTGCGACCTCAGCTCAGGTT
TCGAGAGAAGATCGACAATTCTAACACACCATTTCTCCCGAAGATCTTTGTCAAACCCAATGCCCGGAAG
CCACTCCCTCTGGCTCTCTCAAAAGAAAGGCGGGAACGCCCGCAGGACCGTCCGGAGGACCTGGATGTCC
CCCCAGCCCTGGCAGATTTCATCCATCAGCAGCGAACCCAGCAGGTGGAGCAGGACATGTTTGCACACCC
TTACCAGTATGAACTGGATCACTTTACTCCGCCTCAGTCGGTGCTGCAGAGGCCGAAGCCCCAGTTGTAC
CGAGCTGTGGGAGAGACTCCCTGCCACTTGGTGTCGTCCCTGGATGAGCTGGTGGAGCTCAACGAGAAGC
TCCTGGGCTGTCAGGAGTTTGCCGTGGACTTAGAGCATCACTCTTACAGAAGCTTCCTAGGACTCACCTG
CCTCATGCAGATCTCCACCCGGACAGAAGACTTCATTGTCGACACCCTCGAGCTTCGCAGTGACATGTAC
ATTCTCAACGAGAGCCTCACGGACCCAGCCATCGTTAAGGTCTTCCATGGTGCCGACTCTGACATTGAGT
GGCTGCAGAAAGACTTCGGACTCTATGTGGTGAACATGTTTGACACACACCAGGCAGCACGGCTTCTCAA
CCTGGCTCGGCACTCACTCGACCATCTGCTGAGACTCTACTGCGGTGTGGAATCAAACAAGCAATATCAG
CTGGCAGACTGGAGGATACGTCCTCTGCCAGAGGAAATGCTGAGCTACGCCCGGGATGACACCCATTACC
TGCTCTACATCTATGACCGAATGAGGCTGGAACTGTGGGAAAGAGGCAACCACCAGCCTGTCCAGTTGCA
GGTGGTTTGGCAGCGGAGCAGGGACATCTGCCTCAAGAAATTTGTCAAGCCTATCTTTACGGACGAGTCC
TACCTGGAGCTCTATCGAAAGCAAAAGAAGCACCTGAACTCGCAGCAGCTGACCGCCTTCCAGCTGCTGT
TTGCTTGGAGGGATAAGACAGCTCGCAGGGAGGATGAGAGCTACGGATATGTTCTACCAAATCACATGAT
GCTAAAGATAGCTGAGGAACTGCCTAAGGAGCCTCAAGGCATCATAGCTTGCTGTAACCCAGTACCACCT
CTTGTCCGGCAGCAGATCAATGAGATGCATCTCCTAATCCAGCAGGCTCGAGAGATGCCCCTGCTCAAGT
CTGAAAATGCAGCTGGAGTGAGGAAGAGCGGACCACTGCCTAGCGCCGAGAGATTGGAGAATGATCTCTT
TGGACCCCATGACTGTTCCCACGCCCCTCCAGATAACTACCAGAACACCTCAACTGATGGGACCCTGCCA
CTTCAGAAGCAGCCAAGCCTATTCACTGAGGGCAAAGAAGAGACCTCTGTGGATGCCGGATGCCTCCTTG
CCACAGCCGTCATCACTCTGTTCAGTGAACCTAACACTGAGGAAGGTGGAAAGACTCCATTGACGGTGGC
CCAGAAAAAAGCCCAGAACATAATGCAGTCCTTTGAAAACCCATTTCGGATGTTCCTGCCTTCTCTGGAA
CACAAGGCCCACATCTCTCAAGCAGCAAAGTTTGATCCTTCTTCGAAAATCTATGAAATCAGCAACCGCT
GGAAGCTGGCCAGCCAGGTCCAGGTCCAGAAAGAACCTAAAGAAGCAACCAAGAAGAAGGTAGCTGAGCA
AACAGCTGCCCGGGAGGAGGCGAAGGAGGAGGCTGCAGCCGGTGTGCTGGAACAGGCTATCCCTGTGCGG
CAGCAGGCCGCGCTAGAAAATGCTACTAAGAAGAGAGAACGAGCCACCAGTGACCTGAGGACTATAGAGC
AAAAACAGGAGAAGAAACGACTAAAAAGCTCCAAGAAAGCCAAGGACCCTGATCCCCCAGGGAAAGACTT
CAGTCCCTATGACTACAGCCAGTCAGACTTCAGGGCCTTTGCTGGGGACAGTAAATCCAAGCCTTCCTCC
CAGTTCGACCCCAATAAGCTGGCACCTTCCGGCAAGAAAGGTGTTGGAGCCAAAAAATGTAAACAGTCGG
TGGGAAACAAAAGCATGTCATTTGCTGTTGGAAAGTCGGACAGAGGCTTCCGCCACAACTGGCCAAAGAG
ATAG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_016699
Insert Size 2664 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_016699.2, NP_057908.2
RefSeq Size 2803 bp
RefSeq ORF 2664 bp
Locus ID 50912
UniProt ID P56960
Gene Summary Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA (By similarity).[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (1) encodes the longest isoform (1).
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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