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Disc1 (NM_174853) Mouse Untagged Clone
CAT＃: MC221665
Disc1 (untagged) - Mouse disrupted in schizophrenia 1 (Disc1), transcript variant 2, (10ug)
CNY 10,170.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC221665 representing NM_174853
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCAGGGCGGGGGTCCCCGGGGCGCTCCGATCCACAGTCCGAGCCACGGCGCAGACAGTGGGCATGGCT TACCGCCTGCAGTAGCCCCTCAGAGGCGGCGGCTGACACGGAGACCAGGCTACATGAGAAGCACAGCGGG TTCTGGGATCGGGTTCCTCTCTCCAGCAGTGGGCATGCCACACCCGAGCTCAGCAGGGCTGACAGGCCAG CAGTCCCAACACTCACAGTCCAAGGCTGGACAGTGCGGACTTGACCCTGGGAGCCACTGCCAAGCCTCAC TGGTGGGCAAGCCTTTTCTCAAGAGCTCCCTTGTCCCTGCTGTGGCCTCTGAGGGCCACCTGCACCCAGC CCAGCGCTCTATGAGAAAAAGACCAGTGCACTTTGCGGTTCATTCCAAGAATGACAGCAGACAATCTGAG AGGCTGACTGGGTCATTTAAGCCTGGGGACAGTGGGTTTTGGCAAGAATTATTATCTTCAGACAGCTTTA AGTCTCTGGCTCCTAGCCTTGATGCACCCTGGAACAAGGGATCAAGGGGCCTGAAGACTGTGAAACCTCT GGCATCACCGGCGTTGAATGGCCCCGCTGATATCGCATCCCTTCCCGGCTTCCAAGACACCTTCACTTCC AGCTTCAGCTTCATCCAACTCTCCCTTGGTGCTGCTGGAGAACGCGGAGAAGCAGAAGGTTGCCTGCCAT CCAGAGAGGCCGAACCTCTGCATCAGAGGCCCCAAGAGATGGCAGCTGAAGCATCTAGCTCAGACAGGCC CCACGGGGATCCTCGGCATCTCTGGACCTTCAGTCTTCACGCTGCTCCAGGCTTGGCGGACTTGGCTCAG GTGACAAGGAGCAGCAGCAGGCAATCAGAATGTGGCACGGTCTCCTCCTCCTCCTCGGACACTGGCTTCT CTTCCCAGGATGCATCCTCCGCTGGTGGGCGGGGCGACCAGGGCGGCGGCTGGGCCGATGCCCATGGATG GCATACATTGCTCAGGGAATGGGAGCCCATGCTGCAGGACTACCTACTGAGCAACCGCAGGCAGCTGGAG GTCACTTCCTTAATTTTAAAGCTTCAGAAATGTCAAGAAAAAGTGGTCGAGGATGGCGATTACGATACTG CAGAGACATTGAGACAGAGGTTGGAAGAACTGGAACAGGAGAAAGGCCGCCTGTCCTGGGCTCTGCCTTC ACAGCAACCTGCTCTTCGCAGCTTCTTGGGTTACCTGGCAGCACAGATACAGGTGGCCTTGCATGGAGCC ACCCAAAGGGCCGGCAGCGATGATCCAGAAGCCCCACTTGAAGGACAGCTGAGGACTACCGCCCAGGATA GCCTGCCTGCATCCATCACCAGGAGGGACTGGCTTATTCGAGAGAAACAGCGATTGCAGAAGGAAATCGA AGCTCTCCAAGCACGGATGTCTGCGCTGGAGGCAAAGGAAAAACGGCTGAGCCAAGAGTTGGAGGAGCAG GAGGTGCTGCTCCGGTGGCCGGGCTGTGACCTGATGGCACTGGTGGCCCAGATGTCCCCAGGCCAGCTGC AGGAGGTCAGCAAGGCCTTGGGAGAGACCCTGACCTCTGCCAACCAGGCTCCCTTCCAGGTGGAGCCACC TGAGACCCTCAGGAGCCTCCGGGAAAGGACAAAATCACTGAACCTGGCTGTCAGAGAACTCACTGCTCAG GTGTGCTCAGGTGAGAAGCTGTGCAGCTCTCTGAGGAGGAGACTCAGTGACCTCGACACCAGGCTGCCTG CCTTGCTGGAAGCCAAGATGCTGGCCCTATCAGAAACACGCATGAAGGCAAACACTGTGAAGTGCATGGA AGTGTTGGAAGGTCAGCTGAGCAGCTGCAGGTGCCCGCTGCTTGGGAGAGTGTGGAAAGCAGACTTGGAG ACTTGTCAGTTGCTAATGCAGAGCCTGCAGCTTCAGGAAGCAGGCAGCAGCCCACACGCAGAGGACGAGG AGCAGGTGCATAGCACAGGAGAGGCCGCCCAGACAGCTGCTCTGGCTGTCCCTCGAACACCCCACCCCGA AGAAGAAAAGTCCCCCTTGCAGGTGCTCCAGGAGTGGGACACCCACTCAGCTCTTTCACCACACTGTGCT GCAGGCCCATGGAAAGAGGATTCTCACATCGTTTCTGCTGAAGTTGGAGAAAAGTGCGAAGCCATAGGCG TGAAGCTCCTACACCTGGAAGACCAGCTTCTCGGAGCCATGTACAGTCACGATGAGGCTCTCTTTCAGTC TCTCCAGGGGGAGCTCCAGACGGTGAAGGAAACACTGCAGGCCATGATCCTGCAGCTCCAGCCAACAAAG GAGGCAGGAGAGGCCTCAGCTTCCTATCCGACAGCTGGTGCTCAGGAAACCGAGGCCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_174853 |
| Insert Size | 2370 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_174853.2, NP_777278.2 |
| RefSeq Size | 2408 bp |
| RefSeq ORF | 2370 bp |
| Locus ID | 244667 |
| UniProt ID | Q811T9 |
| Gene Summary | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG227173 | Disc1 (tGFP-tagged) - Mouse disrupted in schizophrenia 1 (Disc1) transcript variant 2, (10ug) |
CNY 8,650.00 |
|
| MR227173 | Disc1 (Myc-DDK-tagged) - Mouse disrupted in schizophrenia 1 (Disc1), transcript variant 2 |
CNY 7,890.00 |
|
| MR227173L3 | Lenti ORF clone of Disc1 (Myc-DDK-tagged) - Mouse disrupted in schizophrenia 1 (Disc1), transcript variant 2 |
CNY 9,790.00 |
|
| MR227173L4 | Lenti ORF clone of Disc1 (mGFP-tagged) - Mouse disrupted in schizophrenia 1 (Disc1), transcript variant 2 |
CNY 9,790.00 |
