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Ticam1 (NM_174989) Mouse Untagged Clone
CAT＃: MC221188
Ticam1 (untagged) - Mouse toll-like receptor adaptor molecule 1 (Ticam1), (10ug)
CNY 9,500.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AW046014; AW547018; TICAM-1; TRIF |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC221188 representing NM_174989
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGATAACCCAGGGCCTTCGCTCCGTGGTGCCTTTGGCATTCTAGGTGCCTTGGAAAGGGACAGGCTGA CCCACCTGAAACACAAGCTGGGGAGTCTGTGTTCAGGCAGCCAGGAGTCAAAGCTTCTCCATGCCATGGT ACTCCTGGCTCTGGGCCAGGACACGGAGGCCAGGGTCTCTCTGGAGTCCTTGAAGATGAACACAGTAGCC CAGCTGGTAGCCCACCAGTGGGCAGACATGGAGACCACAGAGGGCCCTGAGGAGCCTCCAGACTTGTCCT GGACGGTGGCTCGCCTGTACCACCTGCTGGCTGAGGAGAACCTGTGTCCGGCCTCCACAAGGGACATGGC TTACCAGGTGGCCCTTCGTGACTTTGCCTCCCAGGGTGACCACCAGCTGGGCCAACTCCAGAATGAGGCC TGGGATCGGTGCAGTTCAGATATCAAGGGGGACCCCAGTGGTTTCCAGCCACTCCATTCTCATCAGGGTT CCCTGCAGCCACCTTCAGCATCCCCTGCAGTGACCAGAAGCCAGCCTCGTCCCATTGACACACCAGACTG GAGTTGGGGACATACGTTACACTCCACCAACAGCACTGCCTCACTGGCCAGCCACCTAGAGATCAGCCAG TCACCCACTCTTGCCTTTCTCTCTTCACACCATGGAACCCATGGGCCCAGCAAGCTATGTAACACACCGC TGGACACTCAGGAGCCTCAGCTTGTCCCTGAAGGCTGCCAAGAACCTGAGGAGATAAGCTGGCCTCCATC AGTGGAGACCAGTGTCTCCTTAGGGTTACCACACGAAATTAGCGTTCCAGAGGTGTCTCCAGAGGAGGCT TCGCCCATCCTCCCTGACGCCCTGGCTGCTCCAGACACAAGTGTCCACTGTCCCATTGAATGCACAGAGT TGTCTACAAACTCCAGGTCTCCCCTGACGTCCACCACAGAAAGTGTTGGAAAGCAGTGGCCTATTACAAG TCAGAGGTCACCTCAGGTTCCTGTAGGAGATGATTCTCTGCAGAACACCACGTCATCCAGCCCTCCTGCC CAGCCACCATCCCTCCAAGCCTCCCCTAAGCTGCCTCCTTCCCCTCTGTCCTCTGCTTCCTCCCCGAGCA GCTACCCTGCTCCTCCAACCTCCACATCCCCTGTTTTGGACCACTCAGAAACATCTGATCAGAAATTCTA TAACTTTGTGGTTATCCATGCCAGGGCTGATGAACAGGTGGCCCTACGTATTCGGGAGAAGCTGGAGACC CTCGGGGTACCTGACGGGGCCACCTTCTGTGAGGAATTTCAGGTGCCCGGGCGTGGTGAGCTGCACTGTC TCCAAGATGCCATCGATCACTCGGGGTTCACGATCCTGCTCCTGACTGCTAGCTTTGATTGCAGCCTGAG CCTGCATCAAATCAACCATGCTCTCATGAACAGCCTTACACAGTCTGGGAGGCAGGACTGTGTGATCCCC CTCCTCCCACTTGAGTGTTCTCAGGCCCAGCTCAGCCCAGATACAACCAGACTGCTCCACAGCATTGTGT GGCTGGATGAACACTCCCCAATCTTCGCCAGAAAGGTGGCAAACACCTTCAAGACACAGAAGCTCCAGGC ACAGCGGGTACGCTGGAAGAAAGCGCAGGAGGCCAGAACCCTCAAGGAGCAGAGCATACAGCTGGAGGCA GAGCGGCAAAACGTGGCAGCCATATCTGCTGCCTACACAGCCTATGTCCATAGCTATAGGGCCTGGCAAG CAGAGATGAACAAACTTGGGGTGGCTTTTGGGAAGAACTTGTCACTGGGGACTCCAACACCCAGCTGGCC CGGATGTCCACAGCCAATACCTTCTCATCCTCAGGGTGGTACTCCAGTTTTCCCCTATTCCCCACAGCCT CCATCCTTCCCTCAGCCTCCATGCTTCCCTCAGCCTCCATCCTTCCCTCAGCCTCCATCCTTCCCACTGC CTCCAGTCTCTTCCCCACAGTCCCAATCCTTTCCATCAGCCTCCTCCCCAGCCCCACAGACTCCAGGACC TCAGCCTCTCATTATTCACCATGCCCAGATGGTTCAGCTGGGTGTCAACAATCACATGTGGGGCCACACA GGGGCCCAGTCATCTGATGACAAGACTGAGTGTTCGGAGAACCCCTGTATGGGCCCTCTGACTGATCAGG GCGAACCCCTTCTTGAGACTCCAGAGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_174989 |
| Insert Size | 2199 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_174989.4, NP_778154.1 |
| RefSeq Size | 2852 bp |
| RefSeq ORF | 2199 bp |
| Locus ID | 106759 |
| UniProt ID | Q80UF7 |
| Gene Summary | Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12855817, PubMed:16002681, PubMed:21703541). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12855817, PubMed:16002681, PubMed:21703541). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12855817, PubMed:16002681, PubMed:21703541). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (PubMed:21703541).[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG210343 | Ticam1 (tGFP-tagged) - Mouse toll-like receptor adaptor molecule 1 (Ticam1) |
CNY 6,370.00 |
|
| MR210343 | Ticam1 (Myc-DDK-tagged) - Mouse toll-like receptor adaptor molecule 1 (Ticam1) |
CNY 5,368.00 |
|
| MR210343L3 | Lenti ORF clone of Ticam1 (Myc-DDK-tagged) - Mouse toll-like receptor adaptor molecule 1 (Ticam1) |
CNY 7,700.00 |
|
| MR210343L4 | Lenti ORF clone of Ticam1 (mGFP-tagged) - Mouse toll-like receptor adaptor molecule 1 (Ticam1) |
CNY 7,768.00 |
