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Tgfbr2 (NM_029575) Mouse Untagged Clone
CAT＃: MC219060
Tgfbr2 (untagged) - Mouse transforming growth factor, beta receptor II (Tgfbr2), transcript variant 2, (10ug)
CNY 4,232.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>NM_029575.3
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGTCGGGGGCTGCTCCGGGGCCTGTGGCCGCTGCATATCGTCCTGTGGACGCGCATCGCCAGCACGA TCCCGCCGCACGTTCCCAAGTCGGTTAACAGTGATGTCATGGCCAGCGACAATGGCGGTGCGGTCAAGCT TCCACAGCTGTGCAAGTTTTGCGATGTGAGACTGTCCACTTGCGACAACCAGAAGTCCTGCATGAGCAAC TGCAGCATCACGGCCATCTGTGAGAAGCCGCATGAAGTCTGCGTGGCCGTGTGGAGGAAGAACGACAAGA ACATTACTCTGGAGACGGTTTGCCACGACCCCAAGCTCACCTACCACGGCTTCACTCTGGAAGATGCCGC TTCTCCCAAGTGTGTCATGAAGGAAAAGAAAAGGGCGGGCGAGACTTTCTTCATGTGTGCCTGTAACATG GAAGAGTGCAACGATTACATCATCTTTTCGGAAGAATACACCACCAGCAGTCCCGACCTGTTGTTGGTCA TTATCCAAGTGACGGGTGTCAGCCTCCTGCCTCCGCTGGGGATTGCCATAGCTGTCATCATCATCTTCTA CTGCTACCGTGTCCACCGGCAGCAGAAGCTGAGCCCGTCCTGGGAGAGCAGCAAGCCCCGGAAACTGATG GATTTCAGTGACAATTGTGCCATCATCCTGGAGGACGACCGCTCCGACATCAGCTCCACGTGCGCCAACA ACATCAACCACAACACGGAGCTGCTGCCCATCGAGCTGGACACGCTGGTGGGGAAGGGCCGCTTCGCCGA GGTCTACAAGGCCAAGCTGAAGCAGAACACCTCAGAGCAGTTTGAGACCGTGGCTGTCAAGATCTTCCCC TACGAGGAGTACTCCTCGTGGAAAACAGAGAAGGACATCTTCTCCGATATCAACCTGAAGCATGAGAACA TCCTGCAGTTCCTGACGGCCGAGGAGCGGAAGACAGAGCTGGGCAAGCAGTACTGGCTGATCACGGCGTT CCACGCGAAGGGCAACCTGCAGGAGTACCTCACGAGGCATGTCATCAGCTGGGAGGACCTGAGGAAGCTG GGCAGCTCCCTGGCCCGGGGCATCGCTCATCTCCACAGTGACCACACTCCTTGTGGGAGGCCCAAGATGC CCATTGTTCACAGGGACCTCAAGAGCTCTAACATCCTAGTGAAGAACGACTTGACCTGTTGCCTGTGTGA CTTCGGGCTGTCCTTGCGCCTGGACCCTACTCTGTCTGTGGATGACCTGGCCAACAGCGGGCAGGTGGGA ACGGCAAGATACATGGCCCCGGAAGTTCTAGAATCCAGGATGAATCTGGAAAACGTGGAGTCGTTCAAGC AGACGGATGTCTACTCCATGGCTCTGGTACTCTGGGAAATGACGTCCCGCTGCAATGCTGTGGGAGAAGT GAAGGATTACGAGCCCCCATTTGGTTCCAAGGTGCGGGAGCACCCCTGTGTGGAGAGCATGAAAGACAGT GTGCTGAGAGACCGAGGGCGGCCGGAAATTCCCAGCTTCTGGCTCAACCACCAGGGCATCCAGATCGTGT GTGAGACTTTGACCGAGTGCTGGGACCATGACCCCGAAGCCCGTCTCACAGCACAGTGTGTGGCAGAGCG CTTCAGTGAGCTGGAGCATCCGGAGAGACTCTCTGGGAGGAGCTGCTCCCAGGAGAAGATTCCAGAAGAT GGCTCGCTGAACACTACCAAATAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCTGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_029575 |
| Insert Size | 1704 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_029575.3, NP_083851.3 |
| RefSeq Size | 4728 bp |
| RefSeq ORF | 1704 bp |
| Locus ID | 21813 |
| Gene Summary | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG226791 | Tgfbr2 (tGFP-tagged) - Mouse transforming growth factor beta receptor II (Tgfbr2) transcript variant 2, (10ug) |
CNY 6,248.00 |
|
| MR226791 | Tgfbr2 (Myc-DDK-tagged) - Mouse transforming growth factor, beta receptor II (Tgfbr2), transcript variant 2 |
CNY 5,700.00 |
|
| MR226791L3 | Lenti ORF clone of Tgfbr2 (Myc-DDK-tagged) - Mouse transforming growth factor, beta receptor II (Tgfbr2), transcript variant 2 |
CNY 7,600.00 |
|
| MR226791L4 | Lenti ORF clone of Tgfbr2 (mGFP-tagged) - Mouse transforming growth factor, beta receptor II (Tgfbr2), transcript variant 2 |
CNY 7,048.00 |
