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Nhlrc1 (NM_175340) Mouse Untagged Clone
CAT＃: MC212112
Nhlrc1 (untagged) - Mouse NHL repeat containing 1 (Nhlrc1), (10ug)
CNY 3,990.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AI505271; B230309E09Rik; EPM2B |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC212112 representing NM_175340
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGGGAGGAGGCGACGGCGGTGGCAGCGGCTGGGGTGCGGCCCGAGCTGGTGCGGGAGGCGGAGGTCA GCCTGCTGGAGTGCAAGGTGTGCTTCGAGAGGTTCGGCCACTGGCAGCAGCGGCGCCCGCGCAACCTGCC CTGCGGCCACGTGGTCTGCTTGGCCTGTGTCGCCGCTCTCGCGCACCCGCGGACGCTGGGCCTCGAGTGT CCCTTCTGCCGGCGGGCCTGCCGAGCCTGTGACACCAGCGATTGCCTGCCGGTGCTGCACCTCCTGGAGC TCCTGGGCTCCACCCTCCACGCGTCCCCGGCTGCCCTCAGCGCCGCCCCCTTCGCGCCGGGGACTCTCAC CTGCTACCACGCCTTCGGCGGGTGGGGGACCCTAGTGAACCCCACAGGGCTTGCACTGTGCCCCAAGACC GGACGGGTAGTGGTCGTGCACGACGGGAAGAGACGGGTCAAGATCTTTGACTCCGGAGGAGGAGGTGCAC ACCAGTTTGGAGAAAAGGGGGACGCAGCGCACGACGTGAAGTACCCACTGGATGTCGCCGTCACCAACGA CTGCCATGTGGTTGTCACCGACGCTGGCGACTGCTCCCTCAAAGTGTTTGATTTCTTTGGCCAGATCAAG CTGGTTGTGGGAAAGCAGTTTTCCCTGCCTTGGGGTGTGGAGATCACCCCTCACAATGGGGTCCTGGTGA CTGATGCAGAGGCAGGGACTTTGCACCTGCTGGAAGCGGATTTCCCTGAAGGGGTCCTTCGGAGGATTGA GAGGTTGCAAGCTCACCTATGCAGTCCCCGTGGGTTGGCAGTGTCATGGCTCACGGGGGCCATCGCGGTC CTAGAGCATCCTTGTGCCTTTGGGAGGACTGGCTGTAACAACACAAGGGTGAAGGTGTTCAACTCCACTA TGCAGCTGATTGGCCAGGTGGATAGCTTCGGGCTGAACCTCCTCTTCCCCTCCAAAGTAACTGCCTCTGC TGTGACCTTCGATCACCAAGGAAACGTGATTGTTGCTGACACCTCTGGTCCAGCCATCGTCTGCTTGGGG AAACCCGAAGAATTCCCAGCCCTGAAGCCTATAATCACTCACGGCCTCTCCCGTCCTGTGGCACTGGCCT TCACCAAGGAGAATTCTCTTCTTGTGCTGGATACTGCATCCCATTCTATAAAAGTCTTTAAAGTGATGGA GGGCAACGGAGGGTGA AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-RsrII |
| ACCN | NM_175340 |
| Insert Size | 1206 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_175340.4, NP_780549.1 |
| RefSeq Size | 2308 bp |
| RefSeq ORF | 1206 bp |
| Locus ID | 105193 |
| UniProt ID | Q8BR37 |
| Gene Summary | E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG226156 | Nhlrc1 (tGFP-tagged) - Mouse NHL repeat containing 1 (Nhlrc1), (10ug) |
CNY 3,140.00 |
|
| MR226156 | Nhlrc1 (Myc-DDK-tagged) - Mouse NHL repeat containing 1 (Nhlrc1) |
CNY 2,850.00 |
|
| MR226156L3 | Lenti ORF clone of Nhlrc1 (Myc-DDK-tagged) - Mouse NHL repeat containing 1 (Nhlrc1) |
CNY 4,750.00 |
|
| MR226156L4 | Lenti ORF clone of Nhlrc1 (mGFP-tagged) - Mouse NHL repeat containing 1 (Nhlrc1) |
CNY 4,750.00 |
