Tnfrsf21 (BC016420) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	TR7, DR6
Vector	PCMV6-Kan/Neo
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >BC016420 GGCAGCGGAGGAGGCGAGTGCTTGATAGTGGCTGGAAGCTTCGCTATGGGAAGTCGCTCTTTAGCACTGT CGCGGCTAGCCCTGCTCTCTGGTTCTCCGCAGCCGCTGTCGTTGGAGAGCACCGGGAGGCGCGGGTTGCG AGCGCGCCTGCTTCTCCCCGCCCGGGCGCCAGCGCCCCTGGGCAGGTGCTGAGCGCCTTTCGGAGCCTCC CCTGCTGCCTCCCTCTTCCGCCTGGGTGCCTGGCTGCTGCAGTGCACATGGGCTGCTGGAGGTAGATGGG CTCACCGCCCGTGAGGCGGCGGTGGATGCGGCGCTGGGCAGAAACAGCCACCAATTCCAGCTGCGGTGGG GCCGAGCGCCCCGGGCGCCGCTGCGAGCCCCGGGCTCGGCCATGGGGACCCGGGCAAGCAGCATCACCGC CCTCGCCTCTTGCAGCCGCACCGCCGGCCAAGTCGGAGCCACGATGGTCGCCGGCTCTCTTCTCCTGCTT GGATTCCTCAGCACCATCACAGCTCAACCAGAACAAAAGACTCTGAGTCTCCCTGGCACCTACCGCCATG TTGACCGTACCACTGGCCAGGTGCTAACCTGCGACAAGTGCCCAGCAGGAACGTATGTCTCCGAGCACTG TACCAACATGAGCCTGCGAGTCTGCAGCAGCTGCCCCGCGGGGACCTTTACCAGGCACGAGAACGGCATA GAGAGATGCCATGACTGTAGTCAGCCATGTCCATGGCCGATGATTGAGAGATTACCTTGTGCTGCCTTGA CTGACCGAGAGTGCATCTGCCCACCTGGAATGTATCAGTCTAATGGTACCTGCGCTCCCCATACAGTGTG CCCCGTGGGCTGGGGTGTGCGGAAGAAAGGGACAGAGAATGAAGATGTGCGCTGTAAGCAGTGCGCTCGG GGTACCTTCTCTGACGTGCCTTCCAGTGTGATGAAGTGTAAAGCTCACACGGACTGTCTGGGTCAGAACC TGGAGGTGGTCAAGCCAGGGACCAAGGAGACAGACAACGTCTGTGGCATGCGCCTGTTCTTCTCCAGCAC AAACCCACCTTCCTCTGGCACAGTTACCTTTTCTCACCCTGAGCATATGGAATCCCACGATGTCCCTTCC TCCACCTATGAGCCCCAAGGCATGAACTCAACAGATTCCAACTCTACTGCCTCTGTTAGAACTAAGGTAC CAAGTGGCATCGAGGAAGGGACAGTGCCTGACAATACGAGCTCAACCAGTGGGAAGGAAGGCACTAATAG GACCCTGCCAAACCCACCACAAGTTACCCACCAGCAAGCCCCCCACCACAGACACATTCTGAAGCTGCTG CCATCGTCCATGGAGGCCACGGGTGAGAAGTCCAGCACAGCCATCAAGGCCCCCAAGAGGGGTCACCCCA GACAGAACGCTCACAAGCATTTCGACATCAACGAGCACTTGCCTTGGATGATCGTCCTCTTCCTTCTGCT GGTCCTGGTGCTGATAGTGGTGTGCAGTATCCGAAAGAGCTCCAGGACTCTCAAAAAGGGGCCCCGGCAG GATCCCAGCGCCATAGTGGAAAAGGCGGGGCTGAAGAAGTCCCTGACTCCCACCCAGAACCGGGAGAAAT GGATCTACTACCGCAACGGCCATGGTATTGACATCTTGAAGCTTGTAGCAGCCCAGGTGGGAAGCCAGTG GAAGGACATCTATCAGTTTCTTTGCAACGCCAGCGAGAGGGAGGTGGCGGCCTTCTCCAATGGATACACT GCAGATCATGAACGGGCCTACGCGGCTCTGCAGCACTGGACCATCCGTGGCCCTGAGGCCAGCCTTGCCC AGCTCATTAGCGCCTTGCGCCAGCACCGACGCAATGATGTTGTGGAGAAGATTCGTGGGCTGATGGAAGA CACCACGCAGTTGGAAACAGACAAACTGGCTCTCCCCATGAGCCCCAGTCCGCTGAGCCCGAGCCCCATC CCCAGTCCTAACGTGAAACTTGAGAATTCCACTCTCCTGACAGTGGAGCCCTCACCGCTGGACAAGAACA AGTGCTTCTTCGTGGACGAGTCAGAGCCCCTTCTGCGTTGCGACTCCACATCCAGTGGCTCTTCAGCACT GAGCAGAAACGGCTCCTTTATTACCAAAGAAAAGAAGGACACAGTGTTGCGGCAGGTCCGCCTGGACCCC TGTGACTTGCAGCCCATCTTTGATGACATGCTGCATATCCTGAACCCCGAGGAGCTGCGGGTGATTGAAG AGATTCCCCAGGCTGAGGACAAACTGGACCGCCTCTTCGAGATCATTGGGGTCAAGAGCCAAGAAGCCAG CCAGACCCTCTTGGACTCTGTGTACAGTCATCTTCCTGACCTATTGTAGAACACAGGGGCACTGCATTCT GGGAATCAACCTACTGGCGGGGTGATTTCATTTCGTTTCTGACTTTTGTGTTTTGGTGTGTATGTATGTG TTTAACAGAGTGTATGGCCGGTGAGTTTGGGTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTC TTTCTTTCTTTCTTTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTGAAAGTGAATGTATAAAGCCTT TACAATGTATAACTGTTGGAAAATGCCCACCACTAAATTTTTTTTAAGTTCCATATATTCTCCATTTTTG CCTTCTTATATATATCTTCAACACTATTCTGTGCACTTTAAAAACTTAACATAAACGCAGTGTGACTTCT CCCAAAAAAAAAAAAAAA
Restriction Sites	RsrII-NotI
ACCN	BC016420
Insert Size	1968 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC016420, AAH16420
RefSeq Size	2748 bp
RefSeq ORF	1968 bp
Locus ID	94185
Gene Summary	Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.[UniProtKB/Swiss-Prot Function]

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.