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Abi1 (NM_145994) Mouse Untagged Clone
CAT＃: MC205664
Abi1 (untagged) - Mouse abl-interactor 1 (Abi1), transcript variant 2, (10ug)
CNY 3,656.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | abi-1; E3B1; NAP1; Ssh3bp1 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC004657
GTCCCACAATACCCGGCGGAGGGAGGGTGGGTGGTTGGCGTCTGGTCTGTGCGGAGCTCGGGTCCCCGGC GGACTCAGCTTCCTCTGTCTCTTTAATGCGAGAGGAAGCGATGCGGAGGGGTGGAAAATGGCAGAGCTGC AGATGTTACTAGAGGAGGAGATCCCGTCTGGCAAGAGGGCGCTGATAGAGAGTTACCAGAACCTGACCCG GGTGGCGGACTACTGTGAAAACAACTATATACAGGCTACAGACAAGAGAAAAGCTCTAGAAGAGACCAAA GCATATACAACTCAATCTCTAGCTAGTGTTGCTTATCAAATAAATGCATTGGCCAACAATGTGCTCCAGC TGCTGGATATCCAAGCATCTCAGCTGCGGAGGATGGAGTCATCCATCAATCACATCTCACAGACTGTGGA TATTCATAAAGAAAAAGTGGCTCGAAGAGAGATTGGTATTTTGACAACAAATAAGAATACATCAAGAACT CACAAAATAATCGCACCCGCAAATATGGAGCGTCCTGTCAGGTATATTCGGAAACCTATCGACTATACAG TTCTGGATGATGTGGGCCATGGAGTTAAGCACGGAAATAACCAGCCTGCAAGAACTGGCACATTGTCGAG AACAAACCCTCCCACGCAGAAACCACCAAGCCCTCCCGTGTCGGGCCGAGGGACTTTGGGACGGAATACC CCTTACAAAACCCTAGAGCCTGTTAAGCCTCCAACAGTTCCCAATGACTACATGACTAGTCCTGCGAGGC TTGGAAGCCAGCATAGTCCAGGCAGGACAGCTTCTTTAAATCAGAGACCAAGGACGCATAGTGGAAGTAG TGGAGGAAGCGGAAGCCGAGAGAACAGTGGGAGCAGCAGCATTGGCATTCCTATTGCTGTGCCTACGCCC TCACCGCCCACTGCGGGCCCAGCAGCCCCTGGCGCAGCTCCTGGTTCCCAGTATGGCACAATGACCAGGC AGATTTCTCGACACAACTCTACCACTTCTTCGACATCTTCTGGTGGATATAGACGAACTCCCTCTGTGAC CGCCCAATTCTCTGCTCAGCCTCATGTTAATGGAGGTCCACTTTATTCTCAAAATTCAATTTCTGTTGCC CCTCCTCCTCCCCCCATGCCTCAGTTGACTCCACAGATCCCTCTCACAGGCTTCGTGGCCAGGGTGCAGG AAAACATTGCTGATAGCCCAACTCCACCACCACCCCCTCCACCAGATGACATTCCCATGTTTGATGACTC TCCGCCTCCTCCGCCACCTCCTCCTGTGGACTATGAAGATGAGGAAGCTGCAGTAGTTCAGTATAGTGAC CCATATGCAGATGGGGACCCTGCATGGGCTCCCAAGAACTATATTGAGAAAGTTGTTGCAATATATGATT ATACAAAAGACAAGGATGATGAGCTGTCCTTTAAAGAGGGTGCAATCATCTATGTTATAAAGAAGAATGA TGATGGCTGGTTTGAAGGAGTTTGCAATCGAGTGACTGGACTCTTCCCTGGGAACTATGTTGAATCAATC ATGCACTATACTGATTAGTTTTTCTTTTTTCTTTTCATGTAGGTTATTACTCCGTCATACTGTGGGATTA TATGGTTAACAGAATTGTTTTAATGTTTAAAATGTGCCCATATTTTCAAGGACATGTTTTATTGGTATAT TTGGATGTCTACCTGTAAGCATAAATTTTGGAGGCAGTTCAAACATTGCTGAGCAGCAGTTTATATGCCT ATAATTGATTATGCATATGTACTCACACCTTGCTAAGTTTATGACCAGCCTAAAACTTCTGGGGATTGGG TATTATGTTTAACAAATCATGGTTCAGAATGCACCATTACATGTTTCAGTGCAGCATGGTCACTAACATT GTGTCAGACTAATAGGAAAAAAACAGAAAACGTCAATGCTGGTGCTGGTCATACTTTTGGTTTCAATTCT CATTTTTAAAAAAATACTGTGTTTAAAGCATGCATAAATTTTTATGTATTGAAATATACTTAACAATTCA AGATGCTTCCAATTTGTGTAACGATTATCTGGAGTACTCATACTTGAGTCTCCTAAGCTCTCCATGTGAA ATGAAAGACTATCTGTAATGTTGTAATTTGTATCTAAGTTTTTTAATGAGTGAAATTTGCATTATAAATT TTTCCATTCATAAATACATAAGTGAACCAAAGGATTTTGGCCTCTCCTTTACTGGTTTGCTTTAATTATG TATGCTAGTGCATATGCATGCACACCCTCCCACCCCTTTAAGAAAGATTTATTGCAGAATTATGGTTCTA TTTTCTCAATGCATCAGTTTTGAAAATATTTTTAGCTTAATCTTAATGTGTCCAAACAGTCAATGTGACA GAATTTTGCAGATTTTGGAGCTAGACTGTGTCAGAGTAAGCACATGATATTCTGGGGGCAACATCTGAAG GAGGAGTGCCACACCGGTCCTTTGGATTTTAATGAAACTGAATTTACATTGACTCAGTGAAAGGAAAATC CTTTACATATTGTAAAGATGGATGCAGTTCATTTGTGGATAGGCATATTTAATCCATTCCCTGGCACTAG AAACATAAAATTTTACAATAATTTTGAAAGAAACTAGGCCATGTATTAATCTGTAAACAGGTAATAAGCA GGTTTGTATTGTAACTTTGATGCAACACATGCACTTTGTGTGTCTCCTTGATTCAAGGGAGGGTGTGAGG GATACTTCTCTTGTATATAAGACTGTACTGCTTAGGATATTAAAGTAGATCACACAAGTGTGGGTTTCTA TGTACTGAGGGTTGCAGATTTATGACAGCATAGTGATGAGAGCAGTGCAAAATATTTCTGAAAATTAAAG ACCATTGTTCCTACCAAATCAATGATTCCATATATATTTTAACCTTTGTTATTTTTGAAGTACTATGTCA TTAGCAATCAGATAGCTTTTTATTATGCATTTCCTTTTTGAAGCAAAATGTTTTCTTCATTTGTAAATAA CCTGTTGTCTAAATTTTATCTAGTCTTTTATAATAAACTATGCTCCTATATGAAAAATTTGGATATTGTT AAAGTATAACTAATGTGGATTTAAATAGTACAGACTTCAAAATTCTCTGACCTTTAATCCTATGGTGAAA CAAAGACAAACCACTTGAATTTTAACGTTGATTATTTATTTGTGTAATGGCTTTACATGTGGGCATTAAC AGTGTAAACAATACCACATATAACCATCAGGATACCTCGATTAGAATTTATAGGACTATAATGACACTGG TTTAATTACATTTAAAAAGTTTTCCGAAAAACTTTGCCAATAAAAATTGCCCATCAATAAGGTTGAAAAA AAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_145994 |
| Insert Size | 1431 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC004657, AAH04657 |
| RefSeq Size | 3371 bp |
| RefSeq ORF | 1431 bp |
| Locus ID | 11308 |
| Gene Summary | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG217178 | Abi1 (tGFP-tagged) - Mouse abl-interactor 1 (Abi1) transcript variant 2, (10ug) |
CNY 5,230.00 |
|
| MR217178 | Abi1 (Myc-DDK-tagged) - Mouse abl-interactor 1 (Abi1), transcript variant 2 |
CNY 4,750.00 |
|
| MR217178L3 | Lenti ORF clone of Abi1 (Myc-DDK-tagged) - Mouse abl-interactor 1 (Abi1), transcript variant 2 |
CNY 6,650.00 |
|
| MR217178L4 | Lenti ORF clone of Abi1 (mGFP-tagged) - Mouse abl-interactor 1 (Abi1), transcript variant 2 |
CNY 6,650.00 |
