FZR1 (NM_016263) Human 3' UTR Clone

Specifications

Product Data
Product Name	FZR1 (NM_016263) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
ACCN	NM_016263
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC217036 3’UTR clone of NM_016263 The sequence shown below is from the reference sequence of NM_016263. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGCTCAACCTCTTCACCAGGATCCGGTAAACCTGCCGGGCAGGACCGTGCCACACCAGCTGTCCAGAG TCGGAGGACCCCAGCTCCTCAGCTTGCATGGACTCTGCCTTCCCAGCGCTTGTCCCCCGAGGAAGGCGG CTGGGCGGGCGGGGAGCTGGGCCTGGAGGATCCTGGAGTCTCATTAAATGCCTGATTGTGAACCATGTC CACCAGTATCTGGGGTGGGCACGTGGTCGGGGACCCTCAGCAGCAGGGGCTCTGTCTCCCTTCCCAAAG GGCGAGAACCACATTGGACGGTCCCGGCTCAGACCGTCTGTACTCAGAGCGACGGATGCCCCCTGGGAC CCTCACTGCCTCCGTCTGTTCATCACCTGCCCACCGGAGCCGCATGCTCTTCCTGGAACTGCCCACGTC TGCACAGAACAGACCACCAGACGCCAGGGCTGATTGGTGGGGGCCTGAGACCCCGGTTGCCCATTCATG GCTGCACCCCACCATGTCAAACCCAAGACCAGCCCCAAGGCCAGACCAAGGCATGTAGGCCTGGGCAGG TGGCTCGGGGCCACTGGCGGAGCCAGCCTGTGGATCCAAGAGACAGTCCCCACCTGGGCTTCACGGCAT CCTTGCAGCCACCTCTGCTGTCACTGCTCGAAGCAGCAGTCTCTCTGGAAGCATCTGTGTCATGGCCAT CGCCCGGCGGTCAGTGGGCTTCAGATGGGCCTGTGCATCCTGGCCAAGCGTCACCCTCACACTGGAGGA GGATGTCTGCTCTGGACTTATCACCCCAGGAGAACTGAACCCGGACCTGCTCACTGCCCTGGCTGGAGA GGAGCACAACAGATGCCACGTCTTCGTGCATTCGCCAACACGTGCCCTCACAGGGCCAGCGTCCTCCTT CCCTGCGCAAGACTTGCGTCCCCCATGCCTGCTGGGTGGCTGGGTCCTGTGGAGGCCAGCAGCGGTGTG GCCCCCGCCCCCAGGCTGCCTGTGTCTTCACCTGTCCTGTCCACCAGCGCCAACAGCCGTGGGGAAGCC AAGGAGACCCAAGGGGTCCAGGAGGTGGGCGCCCTCCATCCTTCGAGAAGCTTCCCAGGCTCCTCTGCT TCTCTGTCTCATGCTCCCAGGCTGCACAGCAGGCAGGGAGGGAGGCAAGGCAGGGGAGTGGGGCCTGAG CTGAGCACTGCCCCCTCACCCCCCCACCACCCCTTCCCATTTCATCGGTGGGGACGTGGAGAGGGTGGG GCGGGCTGGGGTTGGAGGGTCCCACCCACCACCCTGCTGTGCTTGGGAACCCCCACTCCCCACTCCCCA CATCCCAACATCCTGGTGTCTGTCCCCAGTGGGGTTGGCGTGCATGTGTACATATGTATTTGTGACTTT TCTTTGGATTTGTTTTGTGTTTTTGTTGACTAGTCCTGGAAATGTTTGAGGCTAGACGGGGAGGGGCCA GGACCCACCCACTGCTCCTGGGGGATGAGGTCCTGGTTTTAAAGCCCCGTCATTTCAAGCGGGTCGATC TTCCACATTCACTGGAGAGACTCTCCCCACCTCTGTCTGGGTGGGGCGCGGACCCCTCACTGTGCGCCT GTGCAGGGGGTGCTGGTGCACGTGGCAGTGTGGATTTCCAGTGGTCACGGTCTTACTGTTTCAAGGTTT TTAAATAAGAAAACCAACCCTGCCTTCGCCCATGCCCGCCCCTGCCCGCAGTTGCCAAAGAGCCGCCTT GTCGCTGTGGGCGTCAGGGCTTGGCTGGCTCAGTGCACAACCCACAGTGGCCTTCAGAGGCTCCTCCTG GGACTGGGAACCGCCGCAGGGCCAGGCGGACGGCGTGAGGTTTGTGTTGGGGCTGGTTCTGCCCATGCT AGGGGGTGGGGGAGCTCCCAGGACAGACCAGCCTTGTTTCTCATGTAATGCAGTGACGCTGTCATTAAA CACGTGGATTCATGTGTGGCCGGGACTGGCTGGCTCTAGGTCCCCGGCTCGGGTGGGGTCACACGGTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_016263.4
Synonyms	CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
Summary	Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).[UniProtKB/Swiss-Prot Function]
Locus ID	51343
MW	71

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