SPPL3 (NM_139015) Human 3' UTR Clone

Specifications

Product Data
Product Name	SPPL3 (NM_139015) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	IMP2; MDHV1887; PRO4332; PSH1; PSL4
ACCN	NM_139015
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC216486 3’UTR clone of NM_139015 The sequence shown below is from the reference sequence of NM_139015. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCCAGCAGCTCCCGATTCCTGGAAGTATGATGGATCACGTGGAAAGTGACCAGATGGCCGTCATAGTCC TTTTCTCTCAACTCATGGTTTGTTTCCTCTTAGAGCTGGCCTGGTACTCAGAAATGTACCTGTGTTTAA GGAACTGCCGTGTGACTGGATTTGGCATTTAAAGGGAGCTCGTTTGCAGGAGAGAGGTGCTGGAGCCCT GTTTGGTTCCTTCTCTTCCTGCGGATGTAGAGGTGGGGCCCCTTCCAAGAGGGACAGGCCTCTCCCCAG CGCGCCTTCCTCCCACGTTTTTATGGATCTGCACCAGACTGTTACCTTCTGGGGGAGATGGAGATTTGA CTGTTTAAAAACTGAAAACAGCGAGGAGTCTTTCTAGAACTTTTGAACACTAAAAGGATGAAAAAAATT AGCAAACCGAAGTTTCTTCAATGACCCCTCGAGAACTTTGGGACCAGTTTCCTATAGGGGACTCAGTTT CAGAGAACTGAGACAGAAGCTCTTCTGTCGTTATATTCTTCTTTCCTTTTTTTGGATTTATTAAATATT TTCTGTGGTGTGAAGTGACTTATTAAATCCACAGACATTGAGTGACTTCTTACAACATCCACATAAGAA TTTGTTGTAATGAGTTCATGTCCACCCAGATGTTGTGTTGGCAGTGAACAAGGGCACGGTTTTTATACA TACGTACATATATATATATAAACACACACATAGATATATATGAATAAACAAAAATGAAATCCTGCTAAG ATCACGCTGTGTAGCTGACAGGGGCTTGCTGTCGTTTTGAGCATGTCGAGCAGTTTACTGTGGCTTCCT TGTATATGGATAAGCTGCTGTCCTTCCCCTTCACAACTGACCCCGCAGTTACAAACTAGTATAGCATTT GTGCTGATTGATGATAGACTCATGGACTTCAGGAGCCCTTACTTGGTTTTGATCAGTGTAGCAAATTAG GGATGAAGAGTTCAAACCTTTTGGCCCTTTCTTTCTTTTCTAGGCTTCTCCCTCGCAGGGTGTTCCGTA GTTTCTTCTCGAGCCAATGCATGTATTATAGCAGCAGGTGTCTTTGTGCTTTCTCATCATAGTAACGTA CTACTTGTAAATACATTTTTCTATTTTCTATTTTTTTGTATTTTTTTTTTTGACATTTTGTTTCATTGG TGTGCTGTATATTTTCCATGCCCTCACTCCTTTAAGAAAAAAAAAAAGGAAAAAAGCAACACAATCCTG TCCTTGCTGTTGTGATTATAGTCTTGGTTTACCTGTGGTGACAACCGGGTGTTGGGGACACATGTCAAA TGCCCCTCTGAGATGGGCCCTAAATTCCAGTAACTGGGGAAAGAACCAGCTGCTGTGTCCTGAGAGCCT GGCCCTGTGCTGTGGTCTCTGCTGCAAGCCCAGATTTCTGGGAGTAACTAGTGTTAGGTCTGCTGACCT TTACCTAAGCAGCCCCTGCCTGGTAAGAAGGTGCCCATTGTTCAGAGGCAAAGAGAAGCCTGCGGTTGG CATGAGGATGCCTGACAACAAAGGCTGGAGAAGGGCCCTGAGTTCCAGCCTCTCCCCAAGGGTCCCCGC CCCAGTGGCTGCCTCTGTCTTGACCTGTGTAATGAATTAGTGTGCTGTGTCACTGTGGCTTGAAGTCAC TGTGGATCGAGCTCACAGGGGGCACCCATCCTGTTGTCAACAGAGTCTGAAGCAGTCAGGGTGTTGGAT TCCTCTGTTGTTGTCATCAATTCCTGCTGAGGGGTTTCTGGGGTTTTGTTTTTAATAAATGACTCCTTT GTAGCCTTTGTCACATAATCTTCACTTTGGTTGTTGGTACCAAACAGAGCTCCCAGCCATCTCCTCCCT GTTCTGGAAGACTGATGGGAAGACTCTGTCTGTCCCCAGACCTGGTCATCTGCAGCTCTGGCCCAGTCA TAGATACATCAAAGAACTGAAGCTTCTGCTGTCCACAGAACTCAAAACTGCCTCTGCATTGGGTGAAG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_139015.5
Synonyms	IMP2; MDHV1887; PRO4332; PSH1; PSL4
Summary	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).[UniProtKB/Swiss-Prot Function]
Locus ID	121665
MW	74.3

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