KRIT1 (NM_194456) Human 3' UTR Clone

Specifications

Product Data
Product Name	KRIT1 (NM_194456) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CAM; CCM1
ACCN	NM_194456
Insert Size	1797 bp
Sequence Data	Insert Sequence (showhide) >SC216368 3’UTR clone of NM_194456 The sequence shown below is from the reference sequence of NM_194456. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGTTAATGCCCACTGAAAGAAATTCATGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAA TGCAGAGTTTTTTTTCCGTGAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGTGGCTCACCCCT GTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAGAGTTCAAGACCAGCCTGGC CAACATGGTGAAACCCTGTCTCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAAT CCTAGCTACTAGGGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAG ATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCCATCTCAAAAAAAAAAAAAAATTACTT TCAACAAGGCATATAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGT TTGGTGTGTAATATACCAATTAGTTTTATATAATATCCTCATAAGCTATTCTAATTTTTGAGAGAAACA CAAAAAGTTATAGATTGATAGTCTGTATAATATTAGACAAAATAGTAAGCTTTATAAAAAGTTATTTTT GGTAAATGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATGTG TATTTCAAAATATACTGAACGTCAACATGATTTGAATAAAGAAAATGTATTTTCTACTTGAACCACATA ACACTGTTATTTAAAACAGTTTTCTGCAGTCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGTT AAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCATCATAATTAC CTAGATGCCTCTTAAAAATGAAGATTTCAGAGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTA GCATGGCCTTGTGAACTTAAATTTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAA TAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACACAAGCACACACATACAT AGACACATTTTAAGTGATAATCTCTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTA TGAGTTGACTTAATAGTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCACCAGATATCTTATTG TTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGAATGTGCTATTCATAAGCTAGAAA CTACAGTTTTTCCAAACTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGT TGTCCTACAGTTTGCAGATAATTTTTATATTACTATTCTTCACATTAACTTCTGCTTATTTTTAATGGT ACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTTAAGTAAAGTTAACAAGAAAGCCTGATTTAT CTTTAATTCTGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAAT GTCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACCTAAGATTTTAGCCTCAACTTCTTTTCTGA ACTTCAAATCTTAATTTCCAAGTTATACTTGTTCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGT TGAATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATATTCCCTA TTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_194456.1
Synonyms	CAM; CCM1
Summary	This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Locus ID	889
MW	70

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