RBM24 (NM_001143942) Human 3' UTR Clone

Specifications

Product Data
Product Name	RBM24 (NM_001143942) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	dJ259A10.1; RNPC6
ACCN	NM_001143942
Insert Size	1782 bp
Sequence Data	Insert Sequence (showhide) >SC216295 3’UTR clone of NM_001143942 The sequence shown below is from the reference sequence of NM_001143942. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGCAGCTGCAGACAGACCGAATGCAATAGACCAGCCATCTGATCAAAGTTGAATTGTTTTCTCTTTCC CTCCCAATTTTCCAATTTTTAGTAGCTAATAAGAGAGTTAACATTGACTTAACAGCTTTAAAAAAAAAA ACAGCCATGCTATTGTGAAGCAGAGTTATTATTTTTTTTATACTCCAGGTAGTGTTCTAGATGAGAAAG AGGTAAGAATGAGGGGAATGGGCACAATTTTGGAAATCAATCCCAAAGAGCCTGAGTAAATGAAAGGCC ACTACGAAATGACGCCAGGAGTAACAACGGAACTTCACTTTTGTAACGGGATTTTTATTTTTGCTCTTT TTATAGTATCAGGGAAGCAAACTGCCTTTTACAAGTTAGAAAATGCTGTTTGAATCTAGTTGAACCAGG GAATACAGAGCGAGCAATATGTAGCTTGAATTACATTTAAAAGCAGATTTTTTACAAACAAAATGGCGA AAGCACTGATTGTCATTTTTAGCAGTCACTTAAGGCCTATAGAACTTTTTTCAAGTCGGAAGGTCCTGT TCTTACTATCTCAAAAATGGGCATCGAACAATCAATCTAGGAGCGTGGCAGTGGGTAAAATGGTGGACA GGCACCAAAGCTATTTTCTCATCTGTCCTGTGGATGAGTGGAACTGTGGAACAAGTGATGTGGAATTAA TGGGTGCAACAGCTGTACAGACAATCAATAACACACACAGTTCTGGAAAGAACACATCACTTGTGCTTG TTTGATGAGCTTGTCACATTCTAATCCCTCTCCCCATCCTGTTTCAATTTTGGGAAACTTGTATCTGCT GGTGTCAGCAATTCTGATTCTGAAATAGGATCAGGCTTTTACTACAACAGCCTTCTCTTTCTATTTATT GTGTCGACTCGTGGCTTATGAATAAAGGCAGGCAAAGTTTGCAGAACTGTCTTAAGGACATTTATTTTT TTTCCCTTTTTAAGTAATTTTACACTTTAGTATCTATTTCAGAGTCATATTTAAAACTATTTATTAGTG ACTACAGTACATGAGACAACAAGGTTACTGAGATTACAATTCTTCAAAGGTTAATGATAATGTGGTTTA TACTGTGCCTTAATAGTAATGCTATTTAAGATATTTATTTTTAAGTTTTACTATGCTGCACTCTAAAGA AAGGAACTTTAGATGTGACACTGTAAAATTATGTATTCATCTCATGGCATAAATTATTTAGTAAGTCTA GATGTAGCGTATTAAATATTAACCTATTCAACTAAAGATGTTGACTTGGATTTATTTAAATTCATATGT GCACTGTATAAGAGAGTACTCTTACATTAACACATTTTAGTTTAGTTTTTAGATTTTTTTTTAAACGAT ATATTGCTAGTTTCATGCTTCCTCCTCTGATTTTGCCTGTGTAGATTTCATTTATTGGTAATTCATTAG TTTAACACTATTATGTAGTTTTTAAATGCTGCTTTACATTTTTCTTCTGAAACTGCAATACTTGCAATT TTTATTCTTAAACTAAATTGAATACTATTTTACACTGTATTGGATTTTTATACTTGAACAATTTCATAC AAGGGAAGACAGGTTAGCATTTTTATGGACTTTCTCCATTATCACTGGATTTACTTTAAGTATTCCCAT ACTAGACAGTGTTATGTAATGTAGACATGACTCTCCTGTGCAAATTATTTATTCGTTGTGTATATTGCT TTATAACATTTCAGATCTTCTAATCTATTCACTTGTATTAAATATAATTTTTAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001143942.2
Synonyms	dJ259A10.1; RNPC6
Summary	Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3' UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3' UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	221662
MW	70.1

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