ABRAXAS2 (NM_032182) Human 3' UTR Clone

Specifications

Product Data
Product Name	ABRAXAS2 (NM_032182) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ABRO1; FAM175B; KIAA0157
ACCN	NM_032182
Insert Size	1726 bp
Sequence Data	Insert Sequence (showhide) >SC216154 3’UTR clone of NM_032182 The sequence shown below is from the reference sequence of NM_032182. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCAGGAACACTCAGACCTCCCAGATTTAACTAAACAAAAGAAACTCTCCACCTAGCACTGTTTTTCTT CATTGCTTACTGAGAGGGTTTTTGAGAACTTAATCTGGGGGGAGAACTGCTTTCTCAGATACCTTAACT CCCGAGAAGAGAGTCCTTGTGCACAGAACTTGTGGGAGCCTCCATCCGCTGCTCTTTACCTTTGGATAC AGTGTGCAAGTTTCATGACAGAATCATTAAGATAATCAAATTGTCCTAATTCTGGTGCGATTCATGGAT ATACTGGTAAATTTAGGCAAAGTGAAACTTATCAGCGTAGTTTCTGTTCTTTAAAATAAATTGGAAATT AGAGACTAAGCACAATTAGTCTATAAATGTTCTATAAATCAAAAACTTACCTCTTGCACTATCATGCCT TGAAATTTACTTTTTCAAAGGGAAACAAGTTTAGCAGCAGCCTTCAAAGAACTTCTTTCTATGATGAGC CAAATTCATCTTTGCCAGAAAAGAAATTTTGATAATTCCAAGAAGCCTGATTAGAACAAATCAGATATA CCTTCTCTTGTCTGCATGACTTTGTGAGATAAAAGAGAGGGCTTCCAACTTTTTTCTACTAGCTTGATA TGTATTATCACTTAAAATGGTTGCCTTTAAAAAAAAAAAGTAGAGATACTAATTACCAGTAAGTAATCA TCCAAATAAATACGTCATAAAATAAATTAATTATTTTTTCTTTGATGGATTACAGTGACTACTGTGTTG CACTGGCACATTTATGGTCTCTGTTCTGGAATCTTGGAGGACACACAGCAGTGGAGAACAGAAGGAGTG AGTTTTATAATGAACAGATTCCAGACACGGTAGGTTTAGCTGAGTTCATACAGAGGAGATATAACTCAT TTAGATCTTCTGACAAATCCTAGTGTTAGTTTTATCTGTGGAGGAAAGACATTTAATAATAAACTGTTT GGGAATCTTGGTGAATAAAGATTCATTTTCAAGCTGAATAACCATACTTATTTTATTTTAAGTTGCCAT TTGGGGAATAATTGCAGTATGTGTAGAGACTCTCTTGGGATGCACTTATATTTTTATTTAATGACTACT TGTTTTCTAGTTTTGCCCACAACGTCTGAAACCACTAAGACATTCAGGAGCATGTTGAGCTTCTGGTTT GGAAACAGCAAGACCCACCATTTATGACAAGGACAGCCATGAGGTTAATACTTGGAGTTTAACTGCCTT CCCTTTGAACTAGTTAAAATCTGTAAGAATAAGGAAGTTGTTGAAGGCTTAAAATCTGGGTTCTGAAAA AGTAGTTTCAGTTTATAGGATACACATTTACTCACTGAGCTCCAGTTCCAATACTAAATTAGACAGTAT CATATAGACGGAAAATGAAATGCTAGAACTGCCGTTCTTTGGATCGCCACTCTATGGGGGTCTGTCTTT TAACTACTCTCCTGGTTATGTTGGCCTTACACCACTGCCATTTGATTTAAAACGCTGCAGACCACTTTA TCTGCAAATGTGTTCCAGTTGTTATCAGCTACCTACTACGCAGCTTCAGCGCCAGTGTGAATTTATTTT TTTTTAAGTGCCATTACCGTCTCCTCTGTTCAGATTTTGACATTCAGGAAAATATTTTTATTTTGATGC CATACTGAAATCTACAATGTATATCTGACAAAGCAGTTAAATGTGACAATAAAAAACTTATTTAATCATG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_032182.4
Synonyms	ABRO1; FAM175B; KIAA0157
Summary	Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).[UniProtKB/Swiss-Prot Function]
Locus ID	23172
MW	66

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