Macrophage Scavenger Receptor I (MSR1) (NM_002445) Human 3' UTR Clone

Specifications

Product Data
Product Name	Macrophage Scavenger Receptor I (MSR1) (NM_002445) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA
ACCN	NM_002445
Insert Size	1715 bp
Sequence Data	Insert Sequence (showhide) >SC215989 3’UTR clone of NM_002445 The sequence shown below is from the reference sequence of NM_002445. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ACTGATCATATTAGGGCAGGGCCCTCTTAAGATCAGGTGGGTTGGGCGGGACATCCTCTGCTACCATCT CATTAAAAGGCCCTTCACCTCTGGACAAGTCATCTGCACAACTGACTTCCAAGATCCTTTTGTGACTCC TCCAAATGACTTTGGTTCCCGTGTTGTACCTGACTTCCACATGGCCTTCTCTCCTGGTCCCTGGTGCTG TTTGGGCCTCTGCTCCCATGCTCATACCTCTTCTTACTCCAATTACTCCACCATCACCTCTCTCCCCTA TCACCCCCAGCCTGGACACCTCTCATGCACGGACTGGAGGGCTGCTCCAACCAGTCCTCAGTTCTCTGC CACCCATTGACCTAGAGTCTTGAACCCAATTTAATTTATTGGGTTCTAGGAGAACTGCTGTGTTCTCAC CCTAACTTGGAAGAGTGATGTTTCAGTCAAGCAAAGCGATTCCTACCATACAATATAACACTTGTGTGA GGCTCTGTCCTAAATATCTCAATTACCAATATGTGGTTTGGTAGTATTTCTCGCCATGCTTTGCTCATG CGCAATGAGACTACAACTAGGGTGTAAATTTTAAGTATCCCATCTAAAACTCATACAATGATAGGAAAA ATCCATTTGTTTTTCATTTGATTTTTACTGAGGAATCAGCTCAATCTTCAATGAATACTGGTCTCTTTC CAAAGCATTTTTGATCAAAGTAAAGACTGAGTCAAGGGCTTTTTTTTTTTCTTTTTCTTGTTTTAAGAG ACAGAGCCTTGTTCTATTGCACAGGCTGGACTACACGCATTCACCTAGAGTCTAGAACACAATTTAATT TATTGGGTTCTAGGAGAACTGTCATGAGTATTGATAATATGAGAGTTCTTTATATTCAAACATTATTCT CAACCAGAGATAGGGATGTCATAGAAGAAAATCCATTCATTCAATCATTAATTCACATGTCCATTATGT ACCTCCATGAGCTGGACATAACAGCTAATAAGAGATAATTGTCTCTGGTTTTACAGAGCTAATTGTCCC TAAGAGATGTAGACAAATGAACAAGCAATTACAATACATCTAAGCTATACTGGGGGAGGAACAGGGCTG GATAGGTATGCAGAGGAGATAAAAAAATTTTAATTCCTTAGAATATTTTTTAAAAATTGATTCTTATTT TACCTTCTCATCTTCTTATTTTCCAAATTACAGCATATATATATATATATATATATATATATATATATA TATATATATATATATTTTTTTTTTTTTTTTTTTTTTTTTTTTAAGTTTTGAAGTGTAGTCGAGCTTGGG CAATTTATCCAACCCATTTAAACCAAAAATAAAACTTTTCATGTATTACCTGGTCATTTCAAACAAAAA TATTTTGATCATGAAAAAGAATACCAATATTCTTTTGTTCTAAAAATCTCTTATGGGATTACATGTTAT ATTTTTGGTTTCTCTCTACTGATCAACAGACTACATTTTCACAACTCTTCTTTCCTTTACGTTTTAACA CACAGACCCAAGATTCATACTATTAAGATTCTAGTAGAACTCTAGATGGTATGCCTCTGTGTATCTCAG CATTTTTATTCCCACTCTTGTATAATGAACATGTTAACACCTACCTCACAGGGTTGTTGTGAGGATCAA GTAAGATATTGTGTGTGTGAAGATGCTCTGTGAAATCATAAAGTCCTTTAAAGATGTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002445.4
Synonyms	CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA
Summary	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Locus ID	4481
MW	66.9

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