Adducin 2 (ADD2) (NM_017484) Human 3' UTR Clone

Specifications

Product Data
Product Name	Adducin 2 (ADD2) (NM_017484) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ADDB; Adducin-2 (beta); adducin 2; adducin 2 (beta); beta adducin
ACCN	NM_017484
Insert Size	1680 bp
Sequence Data	Insert Sequence (showhide) >SC215819 3’UTR clone of NM_017484 The sequence shown below is from the reference sequence of NM_017484. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGCCTGGGGCTGGGTTGCAGGACCCCTGAGTCCTCATACCCACCTTCCCCTGTGATCTTGGGTGCCGG TGCTCTTGCTGCAAAATGGAGGCCAACCTCACAGGGGTGCTGTGAGGACCAGGGAGGACAATGTCTGAT GGCCCCTGTGGGCACTGGGCTGGAGAACAGCAGCCCAGCCTGCCTGCAGGAGTGATGCGGCCGGCTTCC GTACCTCCTGCCATGGAACTCCACTCTGTCCTCCCTTACTACCCCGTGAAGTGGGGACTCATAGGCTTG GGGCTGGAGACTCCCAGGTGCCCCAGGTGTGCCCAGCCCTGAGAGTCTCTGACCTCTGAGCCTGGTATG ACATCATCCAACCAGAGCTCTGGAAAGATGATCATGTACCCATAGAGAAGGGGTATATAGACAGGACCC ATGCTCCTACAGGATGGGAAGGGACAATATTACCCACACAAACCCACATTGAGTTAGAAAGTATTGTAA TTGTTTTTGTGCTTGAGATAGAACAGTGTTTTGTCTAGTGCTTAGCAAAAGGGGTGAAGTTCAGAATTC TGGCATGTGTTTGAAATCACTGCTGCTCCTTGCAAGGTAGCAATGGGCATGACATTTTCCTTAGCAGTA AAAATTGGGGAAATACAGGAAATGTTCCTCTCTGCAGGGCAAATTGTGATGATGCAATGATTTCAGGTC AAGACTGCAGCCCACAGGGTGGGTGCCCATTGGCAGGAGAAGTGTGAAAGTTGTATCATCACACTTACC TCCCCCCAACCCCAACTCAGCCAAGATGGGGAACACTGAATATCCCGCAGGGTCAAGTATAGAAATAGC CATGTTCTGGCGGGAGGTGAGAGTTCATTACAATGAGCAACACTGTTAAAAAAACAAACAAAAATCTCC CCTGCCATTTATACCAAGTGCTCTTCTCGGAGTCCCTCTTCTTGGGTTTTTGGTCTTGGATTCTCGGTT GACTCCATGATTCCCTACATTAGGCCTACTGTGGCCTCCCTTTTGGAAGGGGCCCAGGGGCAGAAGACC TGGCGGGCCAGGGCAGGGAGGACTGGCAGCCTCCAGGCTCACCTCCCTTTGGCTTCACTCTCTTTGCTC CTCAGCTTCAGAGCACTGCATCCTCAAAGGCCAAGATGAGGATGCTGAATTAGGAAAAAAGGCTGTGGA GTCTGAATTTTAGTTCCTATCTTGGGCTAGAGGGGTCAAAGAATTCCTGAAGCTTATGTAAGGGCCGGC TGGTCAGCTCCCTAGAACCACGGGCTCCACAGAGGTGGCAAAACCCAGTGATTTTGCCAGTATCCCTGC AGGGACCTGCGGTACAGGCAGGTTGAAGATCTGAGACTCAGGAACCTTGGCCCCTTTGTCACTTACAAC TGTGTGTGAAACAGGACTAACAGTTTGGACTGAGAGCACTGAAGCTGCTGTGTGTTGTGCATATAACTT AATGCTGTGTGTTGTGGCTTGCACTGCTGTGGGGGCGGGGAGGGCAGTGGTGGGGAATGGCTGGCATGA AGCTTGCTTGAGCCAATGCTATGCTTGCTGGGCTTTGGCTGACTGGCTTTGGGCCACCAACTGTATTTG CATAGTGATGGCTTGGAAGTGTCCATAGAAGGGATTGCAATAAAGGTGTGTCTTCCTTCTGAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017484.2
Synonyms	ADDB; Adducin-2 (beta); adducin 2; adducin 2 (beta); beta adducin
Summary	Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Locus ID	119
MW	61.2

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