LIM kinase 2 (LIMK2) (NM_005569) Human 3' UTR Clone

Specifications

Product Data
Product Name	LIM kinase 2 (LIMK2) (NM_005569) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_005569
Insert Size	1669 bp
Sequence Data	Insert Sequence (showhide) >SC215764 3’UTR clone of NM_005569 The sequence shown below is from the reference sequence of NM_005569. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACGGCCTGACCCGGGACTCACCTCCCTAGCCCTGGCCCAGCCCCCTGCAGGGGGGTGTTCTACAGCCA GCATTGCCCCTCTGTGCCCCATTCCTGCTGTGAGCAGGGCCGTCCGGGCTTCCTGTGGATTGGCGGAAT GTTTAGAAGCAGAACAAGCCATTCCTATTACCTCCCCAGGAGGCAAGTGGGCGCAGCACCAGGGAAATG TATCTCCACAGGTTCTGGGGCCTAGTTACTGTCTGTAAATCCAATACTTGCCTGAAAGCTGTGAAGAAG AAAAAAACCCCTGGCCTTTGGGCCAGGAGGAATCTGTTACTCGAATCCACCCAGGAACTCCCTGGCAGT GGATTGTGGGAGGCTCTTGCTTACACTAATCAGCGTGACCTGGACCTGCTGGGCAGGATCCCAGGGTGA ACCTGCCTGTGAACTCTGAAGTCACTAGTCCAGCTGGGTGCAGGAGGACTTCAAGTGTGTGGACGAAAG AAAGACTGATGGCTCAAAGGGTGTGAAAAAGTCAGTGATGCTCCCCCTTTCTACTCCAGATCCTGTCCT TCCTGGAGCAAGGTTGAGGGAGTAGGTTTTGAAGAGTCCCTTAATATGTGGTGGAACAGGCCAGGAGTT AGAGAAAGGGCTGGCTTCTGTTTACCTGCTCACTGGCTCTAGCCAGCCCAGGGACCACATCAATGTGAG AGGAAGCCTCCACCTCATGTTTTCAAACTTAATACTGGAGACTGGCTGAGAACTTACGGACAACATCCT TTCTGTCTGAAACAAACAGTCACAAGCAAAGGAAGAGGCTGGGGGACTAGAAAGAGGCCCTGCCCTCTA GAAAGCTCAGATCTTGGCTTCTGTTACTCATACTCGGGTGGGCTCCTTAGTCAGATGCCTAAAACATTT TGCCTAAAGCTCGATGGGTTCTGGAGGACAGTGTGGCTTGTCACAGGCCTAGAGTCTGAGGGAGGGGAG TGGGAGTCTCAGCAATCTCTTGGTCTTGGCTTCATGGCAACCACTGCTCACCCTTCAACATGCCTGGTT TAGGCAGCAGCTTGGGCTGGGAAGAGGTGGTGGCAGAGTCTCAAAGCTGAGATGCTGAGAGAGATAGCT CCCTGAGCTGGGCCATCTGACTTCTACCTCCCATGTTTGCTCTCCCAACTCATTAGCTCCTGGGCAGCA TCCTCCTGAGCCACATGTGCAGGTACTGGAAAACCTCCATCTTGGCTCCCAGAGCTCTAGGAACTCTTC ATCACAACTAGATTTGCCTCTTCTAAGTGTCTATGAGCTTGCACCATATTTAATAAATTGGGAATGGGT TTGGGGTATTAATGCAATGTGTGGTGGTTGTATTGGAGCAGGGGGAATTGATAAAGGAGAGTGGTTGCT GTTAATATTATCTTATCTATTGGGTGGTATGTGAAATATTGTACATAGACCTGATGAGTTGTGGGACCA GATGTCATCTCTGGTCAGAGTTTACTTGCTATATAGACTGTACTTATGTGTGAAGTTTGCAAGCTTGCT TTAGGGCTGAGCCCTGGACTCCCAGCAGCAGCACAGTTCAGCATTGTGTGGCTGGTTGTTTCCTGGCTG TCCCCAGCAAGTGTAGGAGTGGTGGGCCTGAACTGGGCCATTGATCAGACTAAATAAATTAAGCAGTTA ACATAACTGGCAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005569.4
Summary	There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Locus ID	3985
MW	61.5

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