D4S234E (NSG1) (NM_014392) Human 3' UTR Clone

Specifications

Product Data
Product Name	D4S234E (NSG1) (NM_014392) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	D4S234; D4S234E; NEEP21; P21
ACCN	NM_014392
Insert Size	1653 bp
Sequence Data	Insert Sequence (showhide) >SC215682 3’UTR clone of NM_014392 The sequence shown below is from the reference sequence of NM_014392. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGACTGAAGCGGCTGAGAAGTCAGCTTAGCGGGATGGGCAAGTTCCTTACAATGTGTCACTTGCAAAT AACAAAGGGACTTTGAGGGACATTTCATTAAATATAATTACTGATACTTTAGAGGTTACTCATTTACGG TGCAATTGCTTCTGTTTGCTAATGCTGCTTTGCAAATAAAACTTGCTGCCGACCACCCACGGGCATAAA ATCAAGTGCATTTCAGCATTGCCTAAAGAGCTCTGACACCACTTTTCATGTTAAGATCTTCATTTAGCT CCTTTACTGGGATTTATTGGATGCTGTAAAAAAATAAATTTACACTGGATATGCGAAGGGTTTGGATCT CAGATAAATGCATTTTGTGGAATTGATTTTCTGAACCGACCCTGCTGTCTGCAAACCTTCCTCCATAGC CATATCTAGAGTGATCTCTCGCTGTGCTAAGAGCAAGCCTACTTCGCATTTCTTCCTCGGCCATCAGCG GGTAACAGTGCTGACTGCTGCCAAGGTGCACTGTAGTAAGTAAGTGGCATAGAGAACGAGGAAAAAGAC CCCCCCACCCCTCCCTGTGCTGACTCCTGAGTCGGGGTGGGACGGCCCTGCAATGTGGCAGGCTCGGTG TGGATTGACTACTCCCTCCCCTCTGACTCTGGCATCTTGGTAAGGAGGGAGGGGCACCACCCATCTGGG TGGAGACAGCTGGGGTTTGCTCCAGTGTGTGTAGACTGGCAGAGCATGTGAGGGAGAGGGCTGGGAAGA GACGGCCCTGGGCCCGTGAGGTGCAGAACTCTCCCTGCAGGTAGTCTGTCTGCTCTGTGATGTGCTGAT AGGAAAGAGCCCCCACTGGCCCTCTGGTTCACTTCTATTATGAATAAATTTGCACCAATAGCCCCATTA GTTTTTAAAGAAATGAGCTGGGTGGGAAAAGTGGAAATGTAATTTCTGGTAAGCTTGAGCTACTTTAAT TTTTATTCTATGAAACTGATATCCCTTGATGTGGGAAACAGGCAGGAAAGGCTGTGGGGTGGGGGTGGG GGACTGGTGTGGCACCGTGCAAACAAAATGACAAATTTCAACTCACAATCTTTGTAAGAAAATTGTTCC AGTTTGAATCTTGATATTAAAGTTTATGTTTACAAAACTGCCAGTTAGATGAACTAAGTGTGTAAAACA AATAGAAAAGACATTCGCAGACATTTCTTCTATGTTATTGAATGTGTTGTTTCTGGTGTACGTGTCAAA AGTTTCAGTTTTTTAGATCAGAAATAAACGACAAATAGTGTGAGATGTGTTGTGAACAGGCATGGTGAC CGTGGTCAGCGCCACTCTTGTTTCCTGAAATGTGCTTCTAAGACAGAAAATGTATTTTCTCATCAAGGG TGTCTGGAGACACAGACCGTGACCTTGGCGCAGCGGTGTGCATCAGAGGCGTGTGCTGAGAAGGGTGGT GTTAAGCTGTGGAAAATGACTCAAGAGCAATAAATCAGTGCCAAAGCTTCCCTGCGCATCTGAATAGAC ACAAGTGAAGCCCGTGTGCGCACAGTGCAGAGGCCGAGCCTGTATTTCCAGGTAGACGTGGACTTTATT GACTGTGAATTCATTTACATGTAACTTCTGACATTTCACTCTGTGCAAATAAAGAACATGAGGATA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_014392.5
Synonyms	D4S234; D4S234E; NEEP21; P21
Summary	Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).[UniProtKB/Swiss-Prot Function]
Locus ID	27065
MW	61.6

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