NOLC1 (NM_004741) Human 3' UTR Clone

Specifications

Product Data
Product Name	NOLC1 (NM_004741) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	NOPP130; NOPP140; NS5ATP13; P130; Srp40
ACCN	NM_004741
Insert Size	1631 bp
Sequence Data	Insert Sequence (showhide) >SC215546 3’UTR clone of NM_004741 The sequence shown below is from the reference sequence of NM_004741. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTCAATTCTATTAAGTTTGACAGCGAGTGACCTGAGGCCATCTTCGGTGAAGCAAGGGTGATGATCGGA GACTACTTACTTTCTCCAGTGGACCTGGGAACCCTCAGGTCTCTAGGTGAGGGTCTTGATGAGGACAGA AGTTTAGAGTAGGTCCTAAGACTTTACAGTGTAACATCCTCTCTGGTCCTTTTCTGTGTTCCTAGTTTT GTACAGACTTGTTTTTGAGTGTTGAGTAGCAGGGACAAAATAAGGGAATGTTATTTTTTAAGAAAATTC ATTTTCATTGTTGTCTCCTTCCTTTTCTGTGAAAGTCCTCATACTGAGAAATTTGTATATTTTATATTA AATCACTTACTATTGATTTTTGTTGTGATTTTCAAAGGTGGATTCCCACAGATAAAATCTTGGCTATTG CCCAAAACATAGTAAAGGGTCACGTGTGACTTTTTATAATAGGAAGAAAATTCTGCCTTTGTGAGTGCA CATGTCCACATTTCATCCCTCCTTCCCTCAAAACCCTAGAGAGGGGCATTAAAGAATTGTTGATGTATA TGCAATGTCTGTTAAGCATGCACTATGTATTTCATCCTCATTTATTGGGTCTGGGACTGAAGTTTTTAG CCAGCATGGACCTAACCTACTTTTTGGGATAAAATTCTCTGTTTTGTTACAGGCAAAATTCTGGTATGG CGTGAATGCCATGGGTCATTCTGAATATATTTTTTTCTGTAATTTTATCATTACACGATGTTTGCAATA CGTGCTTTGTTTTTTAATTTGAAAGCAAACTTTTCTACTGTTGAAAGACATTTTTTGACAACTTGACCC TTCCTAGTATTGAGTTCTAAGTTGAGGACTGCATCTTCTCGTTTTTTACAGTATAGAGAACAAAATGAC ATGAGTTTGAAAAATACATATCACTTGGTATTGCTGTCTTGGTTGCAGTGGTGATACAGAATTGGTTTC ATTAATTCCTACATGGTTGAGAATCACTGATCAAGAAAGTGGGGGGAAAAAAAACAAACGTTAAAACCT CAATCCTCAGTAGGAAGGTAGATTACATTAGGTGAAATTATAGGTAATCTATGTATGTGCTAATGGGGT TGGAAAGAACCTTACAGAGCATATTACCTGATAAACTGGAGTGGGTTTGGGAGAACAAACTAATAGGAT TATTGTGTCTCCTAGTTGGTACCTGGGAGCAATTGACATGCCCCCTTCAGAACCTTAACTGTTAGTAGC AGTGGCTGTAACAACACAAACCAGTGACCAGAGATAACAGCTTTTAGGCCAAGCTGGCCTGACGGTATG GCTGCAGGAAGTGACTGAGCAGTAGCGGTACTCAGCCAGACCAAGACGGAGAGGGAAGAGTCCACAGCT TTCTGGAAGCTAAGGCATTCTGGTGGTAGAAAAGTGTGCCCCAAGCCTTCATGGACGAGTTATAGGTCT TAAGATTAGTCTCCTCTTGTTTGGATTCCATACTTGCTAAATAACCTGATAATAACCTGGTTTTCCATG TAACTGCCTCTAGGAAGAAAATGTACTGTTCATGCTGACACAGATATTTCAGTCTGCATGGTAAAAGTT CTAAATCTTACTACAAAATAATAAACTGGCTGGTTTATAATGTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004741.5
Synonyms	NOPP130; NOPP140; NS5ATP13; P130; Srp40
Summary	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).[UniProtKB/Swiss-Prot Function]
Locus ID	9221
MW	62.7

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