NRG3 (NM_001165972) Human 3' UTR Clone

Specifications

Product Data
Product Name	NRG3 (NM_001165972) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HRG3; pro-NRG3
ACCN	NM_001165972
Insert Size	1604 bp
Sequence Data	Insert Sequence (showhide) >SC215398 3’UTR clone of NM_001165972 The sequence shown below is from the reference sequence of NM_001165972. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATACAAAGAGACTCTGCATTGACCAAGTGACTTGAGATGTAGGAATCTGTGCATTCTATGCTTTGCTCA ACAGGAAAGAGAGGAAATCAAATACAAATTATTTATATGCATTAATTTAAGAGCATCTACTTAGAAGAA ACCAAATAGTCTATCGCCCTCATATCATAGTGTTTTTTAACAAAATATTTTTTTAAGGGAAAGAAATGT TTCAGGAGGGATAAAGCTTACCATTAAAGCTTTTGGGTAGAATTCTGAATCCAATTTCGTTTAGTCCCA ACACTGTCCTCTTTGGCTCTTAGAAGATGTGGGCAATTCAGACCCTTGGCCCCACAGTGCCAGTGTCTC ATTAAAAAACACTGGCAGTTACCTGGTTTCAAAAAGAGGAGAGCTGCATCCCGCAGGTGGATGCACCAG TGAGCAGGTGGCTCTTGCCATTTGGCTTGCCAGTCCCAAGCCCTAAATTTCTATTCACCCAATAGCCTC ATCACAGGTTATGTCATGTCGACACATGTAGTGTTTTCTATTTGATTTTTGGAGAATGCCACAAAAGAC TCTGCAATGGGAAGGAGGACAGGAGATAGAAGGAGAAACCGGGGGCAATCTTAACTACTCTTGTGTGCC ACCTTCCTCTGAGATTTGAATGCACAGATCTCAGCTGGAGGTATGAAATTATTACAGAAAAAGAGACAA AAAAATCCTTATATCGTGTCACTAAAATCATGCTAATAGAAATGTTTTTCCTTGAGATTGTTTAGAGGC TCTGGAGGAGCGTTTCTCAGTTTTTGTGTGCCTGTGTGCACATGTGTGTGCGAGCGTGTGTGTGTGTGG ACTTGCTCACGCGGGCACATATGCTGTAAGCACATGTGTTCATTGTGCGTATGTGTGTGCATGTGTGCG CGTATTACGCTTGCTAAAATTTGTTCTGAAACATCAGGGAATCTACTATTCAGAAAAATTATTTCCCTC TTAGATCTTTTCACTTTAAATTTTTCCATTAAGTATAAAGTTCAGTTAGTTCTTAAATCAAGGTCACTT GCATGGTGGGGTCGTATAAAACTCTTGACACTGTCTAGACCATTTTCTGATGTGAATACTTTTGAGAGG ATCAACTATTGGCTCATTAATGATATCAGTATCATAAGGTGAGTTCATCAAGGATGTGTGTTTATTTTG AATCATGCCTACTTAAATTATTAATACAAGACAATTAACAAATTGACAGTTACCATTTGCTTTCTCATC ATCCTCATTACCATTTATTTTATAGCAAGTCTGCTATGTGTGGACCAAGGCTTCGGCTTCTGTGGTTAG TATGGGAAGAATAAATTGTTGAAATAAAAATACCCAGACTATTCAGTTCACAAGAAGCCCCCCAAAAGA ACAGTAAATTGTGTTGTATGTTCATTTGGAATAAAGCAATATTTTTACCACTGCTAAGGTGAACTGAAA CCTCTCCTGAAGATTTGTCTGTTTATTTACCCTCACTTTCATGGGACATATGAGGAAATTAGTGTTCAC ATATCCAGTCTTTTTCCAATTATTGGTGGTGTTGAGTTGTTATGTTTACACTGTTTTAAATAAAAAGGC ACCGTATTTGAAAGCAT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001165972.1
Synonyms	HRG3; pro-NRG3
Summary	This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Locus ID	10718
MW	61.4

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