Endothelin 3 (EDN3) (NM_207034) Human 3' UTR Clone

Specifications

Product Data
Product Name	Endothelin 3 (EDN3) (NM_207034) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ET-3; ET3; HSCR4; PPET3; WS4B
ACCN	NM_207034
Insert Size	1563 bp
Sequence Data	Insert Sequence (showhide) >SC215384 3’UTR clone of NM_207034 The sequence shown below is from the reference sequence of NM_207034. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CGCTGCCTCTTTCAGGAAGGAGCCCCTTAGGAGGACAGGCCTGCAGCATCCTGGTCTCGGGAGGCTTCT GTCATTGCTCACACACAGTTCAGATTTCCACCTCTTTATAGACAAGAAGTGAATTTGCCTGGGGCAGAA CACCCACCCAAAGAGTCCCCACTTAACAATACCCCCCCCCCACGGCAAGAATGCCCAAATCCGAATGAC CCCAGTTTTCCTAATGAGTAAAATGATCCCAGATGTGCCCCAGAGCATGACGCCTGCAGCTCCGGTTTC ATGCAGGAAATTGGTTTTGGAGAGTTTTGGCAAGTTGGAAAGCCACTTACTGGCTTTTGACATGACTTC TCTTGGAGAATAAGTGGACTCCAAGCTAACTCTTTGCAAATGTAAACACATGTCCATCTTGTAATAAAT GCAAAATGCCCGTGCAGCAGAAGCATGCGACTTTCATATCCTTGCCTAGAATAGGCTGCATGGTGTATG TCAGTGAGGGCCACGAGGCGTCGGCTTTAGACACAGATCATAGCTCTACAGGAGTTTATGAATTTGAAG CTTATGGGATTTTGGCAGAGAAATTTTCAGCTGTGCTTGATACCCACCAAAAGAATGTATCTCGAAAGA ATGAAGGAAGAAGAAAAAAGGATCCTTGATGTTTGTGACAAGAAAATGAGAAAGTTAGTATCTGCAATA CAGAGCTTGTTCCTGTTCAGTGACTGACCCTCTGTATTCTGTATAGACACCAGGCCGATACACAGTGGA GTTCCCAGGCCTTGTTTGCAGGAAGCCGACTGTAAAGACAGCCCCAGCTCAAGGCTATTAGGTTGAATA TTTGCTTTCATGAGTAAATGTGGATCTTTGGGGAATGGCTTCAAAATAAGTCACGAACACAAATTCTTT GTAAATTATGTAAATTCCTGTTTATATAAATTGGCAACAACTTATACCGTCTGACAGTTCAAAATCTCT TTCAGCTGCGCTCTTCCCACCGAGCCGAGCTTACTGTGAGTGTGGAGATGTTATCCCACCATGTAAAGT CGCCTGCGCAGGGGAGGGCTGCCCATCTCCCCAACCCAGTCACAGAGAGATAGGAAACGGCATTTGAGT GGGTGTCCAGGGCCCCGTAGAGAGACATTTAAGATGGTGTATGACAGAGCATTGGCCTTGACCAAATGT TAAATCCTCTGTGTGTATTTCATAAGTTATTACAGGTATAAAAGTGATGACCTATCATGAGGAAATGAA AGTGGCTGATTTGCTGGTAGGATTTTGTACAGTTTAGAGAAGCGATTATTTATTGTGAAACTGTTCTCC ACTCCAACTCCTTTATGTGGATCTGTTCAAAGTAGTCACTGTATATACGTATAGAGAGGTAGATAGGTA GGTAGATTTTAAATTGCATTCTGAATACAAACTCATACTCCTTAGAGCTTGAATTACATTTTTAAAATG CATATGTGCTGTTTGGCACCGTGGCAAGATGGTATCAGAGAGAAACCCATCAATTGCTCAAATACTCAG AAAGTACTGTCAAAAGCCTAATAAAAAACCTAAAGTTTGCTCTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_207034.3
Synonyms	ET-3; ET3; HSCR4; PPET3; WS4B
Summary	The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Locus ID	1908
MW	59.6

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