RAD50 (NM_133482) Human 3' UTR Clone

Specifications

Product Data
Product Name	RAD50 (NM_133482) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	hRad50; NBSLD; OTTHUMP00000065928; RAD50 homolog; RAD50 homolog (S. cerevisiae); RAD50-2
ACCN	NM_133482
Insert Size	1595 bp
Sequence Data	Insert Sequence (showhide) >SC215341 3’UTR clone of NM_133482 The sequence shown below is from the reference sequence of NM_133482. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTTAGCTCCCTGGGATTCAATGTTCATTAAAAATATCCAAGATTTAAATGCCATAGAAATGTAGGTCCT CAGAAAGTGTATAATAAGAAACTTATTTCTCATATCAACTTAGTCAATAAGAAAATATATTCTTTCAAA GGAACATTGTGTCTAGGATTTTGGATGTTGAGAGGTTCTAAAATCATGAAACTTGTTTCACTGAAAATT GGACAGATTGCCTGTTTCTGATTTGCTGCTCTTCATCCCATTCCAGGCAGCCTCTGTCAGGCCTTCAGG GTTCAGCAGTACAGCCGAGACTCGACTCTGTGCCTCCCTCCCCAGTGCAAATGCATGCTTCTTCTCAAA GCACTGTTGAGAAGGAGATAATTACTGCCTTGAAAATTTATGGTTTTGGTATTTTTTTAAATCATAGTT AAATGTTACCTCTGAATTTACTTCCTTGCATGTGGTTTGAAAAACTGAGTATTAATATCTGAGGATGAC CAGAAATGGTGAGATGTATGTTTGGCTCTGCTTTTAACTTTATAAATCCAGTGACCTCTCTCTCTGGGA CTTGGTTTCCCCAACTAAAATTTGAAGTAGTTGAATGGGGTCTCAAAGTTTGACAGGAACCTTAAGTAA TCATCTAAGTCAGTACCCACCACCTTCTTCTCCTACATATCCCTTCCAGATGGTCATCCAGACTCAGAG CTCTCTCTACAGAGAGGAAATTCTCCACTGTGCACACCCACCTTTGGAAAGCTCTGACCACTTGAGGCC TGATCTGCCCATCGTGAAGAAGCCTGTAACACTCCTCTGCGTCTATCCTGTGTAGCATACTGGCTTCAC CATCAATCCTGATTCCTCTCTAAGTGGGCATTGCCATGTGGAAGGCAAGCCAGGCTCACTCACAGAGTC AAGGCCTGCTCCCTGTAGGGTCCAACCAGACCTGGAAGAACAGGCCTCTCCATTTGCTCTTCAGATGCC ACTTCTAAGAAAAGCCTAATCACAGTTTTTCCTGGAATTGCCAGCTGACATCTTGAATCCTTCCATTCC ACACAGAATGCAACCAAGTCACACGCTTTTGAATTATGCTTTGTAGAGTTTTGTCATTCAGAGTCAGCC AGGACCATACCGGGTCTTGATTCAGTCACATGGCATGGTTTTGTGCCATCTGTAGCTATAATGAGCATG TTTGCCTAGACAGCTTTTCTCAACTGGGTCCAGAAGAGAATTAAGCCCTAAGGTCCTAAGGCATCTATC TGTGCTAGGTTAAATGGTTGGCCCCCAAAGATAGACAGGTCCTGATTTCTAGAACCCGTGACTGTTACT TTATACAGCAAAGGAAACTTTGCAGATGTGATTAAAGCTAAGGACCTTAAGACAGAGTATCCTGGGGGT GGTGGTGGGGTGGGGGGGGGTCCTAAATGTAATCACGAGTAAGATTAAGAGCAAATCAATTCTAGTCAT ATATTAAACATCCACAATAACCAAGATATTTTTATCCCAAGAATGCAAGATTTCAGAAAATGAAAAATC TGTTGATAAATCCATCACTATAATAAAACCGAAGGTGAAAAAAATTCTGAAAAAAAAAAAAAAAAAAAA AAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_133482.1
Synonyms	hRad50; NBSLD; OTTHUMP00000065928; RAD50 homolog; RAD50 homolog (S. cerevisiae); RAD50-2
Summary	The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
Locus ID	10111
MW	59.7

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