FAM111A (NM_022074) Human 3' UTR Clone

Specifications

Product Data
Product Name	FAM111A (NM_022074) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GCLEB; KCS2
ACCN	NM_022074
Insert Size	1565 bp
Sequence Data	Insert Sequence (showhide) >SC215230 3’UTR clone of NM_022074 The sequence shown below is from the reference sequence of NM_022074. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTAGAAATGATGAGTGATGAGGACTTGTGAGAATTCAGTCTACTGGATTTAAGGGAATGGCTTATGGAG TTGTTATTTCATAGGCATTGAAAATGGTTTTCTAAACTCCAAAATGGTCATCTTATCAATAATAATAAT ATTGACCATTTCCTATCTGCCAGGCATTTTTCTAAGCACATGAAGAAATTAGTCCTAACAACACTATGA GATGGACTATAACTTGCCCAAATTTTTTTTTTTTTTTTGAGACTGAGTCTCACTCTGTCGCCTGGGCTG GAGTACAGTGGTGCGATCTCAGCTCACTGCAACTTCCACCTCCCAGGTTCAAGCGATTCTTATGCCTCA GTCTCCTGAGCAGCTGGGATTACAGGCAAACGCCACCACACCCAGCTAAATTTTTTTTTTTTTTTTTGT ATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCGGGTCTCGAACTCCTGACCTCGTGATCCAC CTGCCTCGGCCTTCCAAAGTGCTGGGATTACAAGTTTGAGCCACTGCACCTGGCTAACTTGCCCTATTT TAAAGTCAAGCAATGGGAAGAATAACAAGATTATATAGTAATCAGTTTCATGACACTAAAAGTCATATA GTCATAGGGTTTTTTCATCTTTCATATCTTTGCCTAAATTCATTTGCTACAGTGCAGGAACCAAAACTT GTTCATCTCATGATTCCCTACATCTGACATAAGGAAAGTAAGTGCTCAGAAAAATGTGCAGGTCAATAA GTTGCAAAAGTTGGGGCTGCAATTAATGCTAACATAAGAGCTAAATGCTTGATTAGAAATGATCTCAAA ACCTTTTAGAATTTCCAAAATCTTCATATTACTGAAACTGTCGGAATATATGGGTCTTGAAATTCAGAA GATGATAGTCACTCTTCCCATATTTATAGGCTATTAAGGCAAGGGATATCTTAAACATCATATTACTTT ATTTAGATTTCTACTACTCCAATTATTAATGTTATGTATTTCTCATTGTTTTACTTCTTCATGGTATTA TGAAGACTATATAGATGATTCAACCAAGCCTGCAAATCTCCCTCTTGTGGAATTCCACTGGACCCAATC TGTTTTCCATTTCCATTGCAATACTACTAAAGCCATACAATATCAAGCACCCTCCCTCTAGGTCCAGGG ACTATCACAGAAGAAGCAGGCATGTAAGATTTTAAGGACTGGTTTCGAGGGGTCGAGTGTAGGAAAACA GCCTGTTGCATTGTAAGAGTGATGTCATCTTGAAGAGCAGCTGGCATGATGACTGCTGTTTGACTCCTG CATACCAAGATATTCTGCAGCAATGTCTTTAAACAGTGCCGGTAGTACAGATAACCCCTCATAAAGATG CTTATCTAACCTCCCCAGTGTTCAGGTGTTTCACAAGAAAGTCTGAGATATGACTAGCTACACGTTTTG CCAAAAATGCTTGTTATATAAAGGGTACTTTTGGGAGGGTGAGTGCCGCCATTTAGTGGCTGCTAGAAA CATTGCTTCTGTTTGTAAGTTCCTATTAAATGTTTCTTTCTGAGAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_022074.4
Synonyms	GCLEB; KCS2
Summary	The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Locus ID	63901
MW	59.3

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