RFX5 (NM_000449) Human 3' UTR Clone

Specifications

Product Data
Product Name	RFX5 (NM_000449) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_000449
Insert Size	1576 bp
Sequence Data	Insert Sequence (showhide) >SC215217 3’UTR clone of NM_000449 The sequence shown below is from the reference sequence of NM_000449. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CATAAAGACCCAAAAGCAACACCCCCATGATACAGGTCTGTGGGGAAGAGTGTTTATATCCCTACGTTA ACTTTGCCTAGTAGAGGCCCTTCTTTGCACTTGCTTCTCATTTGGCTATTCTTTTCCTAAGGAAGTCCA TTCTCCTCTGTACAGACAGCTGAGTCACCCAGTCTACTTAGTACCTGGTTGCTGCCTCTGACCTTTTCA GCTTGATACCCTGGGCTTTAGTGTAACCAATAAATCTGTAGTGACCTTACCTGTATTCCCTGTGCTATC CTGTGGGAAGGTAGGAATGGGCTAAGTATGATGAATATATAGGTTAGGGATCTTTTGGTTTTAAATCAC AGAAAACCTAATTCAAACTGGCTTAAAATAAAAAGGATTTATTGGTTCATGTAACTAGAAAGTCCATAG GTAGTGCTGGCTCCAGGTGAAGACTTGACCCAGTAGTTCAGTATGTCTCTAAATACCGGACTGACTTTT TTCTCACTGTTGCATCTTCTGTAGGACCATTTAAGTCTGGGCCACTTAATGGCTGCCAGCATTCCTAAG ATTACACTTTTCCCCATTTATGTCCAATCAGAAAAAGAAGGCATCTTTGTACCAGAAATCTCAGCAAAA GCCCTAATATTCACACTGATTAGGCCTGGGTCACATGTCCACCCTGACCAATCACTGTGGCCAGGAGGA TGATACATGCTAATTTGCTTATTCTATATCATGGACAACACCTTTGGGGAAAAGGGTGGGGGTCAGCCT CCCCAAAATCACATGGATTCCCCAAGTGGAAACTAGGAGCAGGGAGTTGCTTGGGTGGCCGCTAACACC AGGCTACTCTTATTTTAGCTTGCTAAGTTGAGATCAGCTAGACCTGCTTTCTTTTCTCCTCAGTCTTGC ATTTCCCTCAATACAAGCTGTAGCCTCTTTCCTCGTTTCTAGTCTCAGAAGGAAGGAGAGGGAAGCCAT TCTCCTCTAGGGACTCTTCAGTCTCATTTAGATGATAGTCCCTTTTTTTCTACCTCCATATTAGAGATG GAGCTCCTTCCTTTTCCTGTTTCTTAATTTTTGTCTTCTCATTCCTGCTTCCCTCTCACCCTATTGCCA GTTCCACCAACTAGAGTGAAAGACTTCCTAGCCATTTCATTAAATCTATTCTGTATCCACCAGGTGGCA GCATCTTGTCATACGTGTCAGGACTTAGGACTGCGGGGTTTAGGTTAGATGTCACGGAAAAAGCTAGTT CTGTGGTCAGGCGGCACCAATGAGAAAGGAATGCAGACCCTCCAGATGTATCCTTGGGAAAAGCAGTAA ACCAACTAATATTTATTGAAGACCTACTTTGTCCTCTACATAGGGTAGCTTCTGTCAGGGAATCTTGGT TCTTCCCAAGAAACACTGATTTTCTTTCAGGGAGACTTCATGTGTTCATTTATTTCCACCACAGCAGAT TTTAAGAAATTATAATATGTAATATTTGATATCTATAAAGAGTATATCTAACGTGAATAAATTATGAAG CATACTAATGAGTACCTATGACCCATAACACATATACATTAAAACATTTTAAATACCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000449.4
Summary	A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]
Locus ID	5993
MW	59

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