alpha 2a Adrenergic Receptor (ADRA2A) (NM_000681) Human 3' UTR Clone

Specifications

Product Data
Product Name	alpha 2a Adrenergic Receptor (ADRA2A) (NM_000681) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
ACCN	NM_000681
Insert Size	1543 bp
Sequence Data	Insert Sequence (showhide) >SC215098 3’UTR clone of NM_000681 The sequence shown below is from the reference sequence of NM_000681. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGTCGGGGGGACAGGAAGCGGATCGTGTGAGGTTTCCGCTGGCGCCCGCGTAGACTCACGCTGACTGCA GGCAGCGGGGGGCATCGAGGGGTGCTTAGCCCCAGGGCACTCAGAAACCCGGGCGCTGCCTGCTCTGCG TTTCCTCGTCTGGGGTGGCTCTGCAGCCTCCTGCGGGCGGGCGTCTGCTGCTCCTACAAGGGAAGCTTC TTGCTGCCAGGCCCACACATCCCCAGTTGTTGGTTTGGCCACTCTTGACCTGGAGCCATCTTCCTAGTG GGCCACCCCTAATCACTATTGCTTCCTAAAGGTATTTTCACCCTCTTCGCCTGGTACAGCCCTCACAGC TCTTCAGAGCAAGCACTGGACTACAAGGGCATGGCTCACAAAAGGTTAATGGATGGGGGTTACCTAGCC CTGGCTAATTCCCCTTCCATTCCCAACTCTCTCTCTCTTTTTAAAGAAAAATGCTAAGGGCAGCCCTGC CTGCCCTCCCCATCCCCCGCTGTAAATATACACTATTTTTGATAGCACACATGGGGCCCCCATATCTCT TGGCCTTGGTTTTGATGTTGAAATCCTGGCCTTGGGAGAGATGCCTTCCAGGCAGACACAGCTGTCTGG TTCAGGCCAAGCCCCTTTGCAATGCAAGCCCTTTCTGGTGTTATGAAGTCCCTCTATGTCGTCGTTTTC ACCAGCAACTGGTGACTGTCCCTTCGACACGGACCTGCTTTGAGATTTCCTGACAGGGAAAAGATTTCT GTCCATTTTTTTCCTGTGCCTAACAGCATAATTGCCTTTTCCTATGTAAATATTATGATGGTGGATCAA GACATAAGTAAATGAGCCTTTCTGCCTCACATCAGCCCTGTGTATAAAGCCATTATTCTCTGATGCACT GTTTGCCCCAGTAACTCACTTTAAAACCTCTCTTTCCAGTGTTCCCTCTCTCCCTCCAGGGCCACTGCT TGAAGAAGAATATGTATGTTTCTATCTTGTATGTCTGTGTGCCCCTCCTGCCCCGAAAGTGCTGACTAT GGGGAAATCTTTTAGCTGCTGTTTTTAGACTCCAAGGAGTGGAAATTATGTGGAAGAAGCAAACCTGAT ACAATTTGCCCAAGGTAAACAGTTTGAAAAGACAAATGGGCCTGCCAAACTGTACAGTTTCTTCCCCAA GAGCTGTTAGGTATCAAAATGTTGTCCTTTCCCCCCTCCGTGCTTTTCTGGTTGAGATCATGTCATTGA TGAACTGCCAAAGTCAGGGGAGGAGGGCAGAGACTTTGTGTTTACATCTGCATTTCTACATGTTTTAGA CAGAGACAATTTAAGGCCTGCACTCTTATTTCACTAAAGAAAAACTAATGTCAGCACATGTTGCTAATG ACAGTGGATTTTTTTTTAAATAAAAAAGTTTACAGATCAAATGTGAAATAAATATGAATGGAGTGGTCC TCTTGTCTGTTATCTGAGTTTTCAAAAGCTTTAAGACTCTGGGAACATCTGATTTTATGGATTTTTTAA AAATAAAAAATGTACATTATAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000681.4
Synonyms	ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
Summary	Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
Locus ID	150
MW	58.1

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