PRKACA (NM_002730) Human 3' UTR Clone

Specifications

Product Data
Product Name	PRKACA (NM_002730) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CAFD1; PKACA; PPNAD4
ACCN	NM_002730
Insert Size	1454 bp
Sequence Data	Insert Sequence (showhide) >SC214567 3’UTR clone of NM_002730 The sequence shown below is from the reference sequence of NM_002730. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGTGTGGCAAGGAGTTTTCTGAGTTTTAGGGGCATGCCTGTGCCCCCATGGGTTTTCTTTTTTCTTTT TTCTTTTTTTTGGTCGGGGGGGTGGGAGGGTTGGATTGAACAGCCAGAGGGCCCCAGAGTTCCTTGCAT CTAATTTCACCCCCACCCCACCCTCCAGGGTTAGGGGGAGCAGGAAGCCCAGATAATCAGAGGGACAGA AACACCAGCTGCTCCCCCTCATCCCCTTCACCCTCCTGCCCCCTCTCCCACTTTTCCCTTCCTCTTTCC CCACAGCCCCCCAGCCCCTCAGCCCTCCCAGCCCACTTCTGCCTGTTTTAAACGAGTTTCTCAACTCCA GTCAGACCAGGTCTTGCTGGTGTATCCAGGGACAGGGTATGGAAAGAGGGGCTCACGCTTAACTCCAGC CCCCACCCACACCCCCATCCCACCCAACCACAGGCCCCACTTGCTAAGGGCAAATGAACGAAGCGCCAA CCTTCCTTTCGGAGTAATCCTGCCTGGGAAGGAGAGATTTTTAGTGACATGTTCAGTGGGTTGCTTGCT AGAATTTTTTTAAAAAAACAACAATTTAAAATCTTATTTAAGTTCCACCAGTGCCTCCCTCCCTCCTTC CTCTACTCCCACCCCTCCCATGTCCCCCCATTCCTCAAATCCATTTTAAAGAGAAGCAGACTGACTTTG GAAAGGGAGGCGCTGGGGTTTGAACCTCCCCGCTGCTAATCTCCCCTGGGCCCCTCCCCGGGGAATCCT CTCTGCCAATCCTGCGAGGGTCTAGGCCCCTTTAGGAAGCCTCCGCTCTCTTTTTCCCCAACAGACCTG TCTTCACCCTTGGGCTTTGAAAGCCAGACAAAGCAGCTGCCCCTCTCCCTGCCAAAGAGGAGTCATCCC CCAAAAAGACAGAGGGGGAGCCCCAAGCCCAAGTCTTTCCTCCCAGCAGCGTTTCCCCCCAACTCCTTA ATTTTATTCTCCGCTAGATTTTAACGTCCAGCCTTCCCTCAGCTGAGTGGGGAGGGCATCCCTGCAAAA GGGAACAGAAGAGGCCAAGTCCCCCCAAGCCACGGCCCGGGGTTCAAGGCTAGAGCTGCTGGGGAGGGG CTGCCTGTTTTACTCACCCACCAGCTTCCGCCTCCCCCATCCTGGGCGCCCCTCCTCCAGCTTAGCTGT CAGCTGTCCATCACCTCTCCCCCACTTTCTCATTTGTGCTTTTTTCTCTCGTAATAGAAAAGTGGGGAG CCGCTGGGGAGCCACCCCATTCATCCCCGTATTTCCCCCTCTCATAACTTCTCCCCATCCCAGGAGGAG TTCTCAGGCCTGGGGTGGGGCCCCGGGTGGGTGCGGGGGCGATTCAACCTGTGTGCTGCGAAGGACGAG ACTTCCTCTTGAACAGTGTGCTGTTGTAAACATATTTGAAAACTATTACCAATAAAGTTTTGTTTAAAA AAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002730.4
Synonyms	CAFD1; PKACA; PPNAD4
Summary	This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Locus ID	5566
MW	52.6

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